Regularly simulated fasting diet cycles improve the health and lifespan of mice eating high-fat foods
University of Southern California Researchers found that mice on a regular five-day cycle diet seemed to offset the harmful effects that normally affect high-fat, high-calorie diets. The study, published in the journal Nature Metabolism today, analyzed the diet and healthy lifespan of three different groups of mice for a period of two years.
"This study shows that rats can eat a relatively bad diet, but it can be offset by a five-day simulated fasting diet." Senior author Valter Longo, University of Southern California, Leonard ·Director of the Longevity Institute of Davis College of Geriatrics, Professor of Biological Sciences, Dornsif College of Arts and Sciences, University of Southern California. "Our main finding is that compared with mice that only eat a high-fat, high-calorie diet, intervention with this diet can make their hearts more resilient and function better."
According to the researchers, the FMD cycle is genetic The effect of expression indicates the role of adipocyte reprogramming in obesity prevention. Specifically, the influence of diet on fat accumulation and cardiac aging can explain the prevention of premature death caused by high-fat, high-calorie diets.
In humans, obesity caused by high-fat, high-calorie diet is the main risk factor for metabolic syndrome, diabetes and cardiovascular disease. The researchers at
warned that these results should not be misunderstood. They emphasized that they do not recommend people to eat high-calorie, high-fat foods, which are relieved by regular fasting.
However, they say that the potential benefits of offsetting a bad diet in this way should be studied in further clinical trials. These strategies can provide potential health benefits for those who are unwilling or unable to change their daily eating habits.
study authors say that the most effective diet usually requires a fundamental change in daily eating habits. The long-term compliance caused by these requirements is very low.Longo said this study may provide an "optimal time point" for mouse FMD for five days a month.
Longo explained: "Even after the rats in the experimental group resumed a high-fat, high-calorie diet, the improved lipolysis lasted for a long time in their bodies." "Is there a similar sweet spot to humans? , Can you intervene for a few days and still break down fat for several weeks?
He added that early foot-and-mouth disease trials have shown potential benefits for human health. Several clinical studies published by Longo and colleagues show that monthly stuttering can cause fat The reduction in weight does not lead to a decrease in muscle mass and improves cardiometabolic risk factors, especially for people who are overweight or obese. They say this new mouse study shows that these monthly foot-and-mouth disease The cycle can actually restore the normal heart and metabolic health of animals on a high-fat, high-calorie diet, and extend their lifespan. This is a lifelong study that cannot be carried out in humans.
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