Zhou Daihan Master of Traditional Chinese Medicine (1941-)
According to the characteristics of “cancer toxin” which tends to be febrile and often interacts with phlegm, blood stasis, dampness and other pathological products, Professor Zhou Daihan mostly uses to clear away heat and detoxify. mainly, combined with the treatment methods such as promoting blood circulation and removing blood stasis, removing phlegm and dissipating masses, combined with the pathological characteristics of different cancers and viscera differentiation, formulated ten common anti-cancer and detoxification methods based on eliminating evils and detoxification.
Zhou Daihan, director of the Cancer Institute of Guangzhou University of Chinese Medicine, professor, chief physician, and doctoral supervisor, has been in the clinic for more than 50 years. He is good at treating advanced cancer and advocates the clinical advantage of "survival with tumor" in TCM treatment of cancer. Now the academic viewpoints on tumor treatment are introduced as follows for the purpose of enjoying the same experience.
The heat-clearing and detoxification method is one of the important treatments in TCM oncology. All the TCM oncology books published so far have listed the heat-clearing and detoxification method as the first choice for removing pathogens and anti-cancer. The current TCM tumor clinical drugs or anti-tumor drugs According to the selected pharmacological experimental research, Chinese medicines of clearing away heat and detoxification accounted for almost 60%. Knowing the evolution and connotation of clearing away heat and detoxifying method will help to broaden clinical vision and improve clinical efficacy.
The formation and evolution of heat-clearing and detoxifying method
The heat toxin treated by heat-clearing and detoxifying method was first seen in the "Huang Di Nei Jing" as a concept of etiology. For example, in "Suwen·Fuchangzheng Dalun", the name "hot poison" was put forward. "Su Wen · The Most Really Important Theory" says: "Hot is cold", "Heat is treated with cold", and the product that reduces heat and fire, clears and relieves toxins is used to directly eliminate pathogens. Han Zhang Zhongjing's "Golden Chamber Synopsis" has the theory that "yang poison" is the disease, and the first method of clearing heat, detoxifying and removing blood stasis, the representative recipes are the cohosh turkey decoction and rhubarb peony decoction . In Treatise on Febrile Diseases, Gegen Qinlian Decoction and Baitouweng Decoction are commonly used to treat heat dysentery. Tang Sun Simiao wrote in "A Thousand Gold Prescriptions": "Anything that removes heat and detoxification, and has no bitter intoxication.
Therefore, sophora flavescens, green argens, gardenia, grass seedlings, bitter wine, ebony genus, ...The best for detoxification and heat removal.In practice, the clearing away heat and detoxifying prescriptions have been flexibly applied to acute fever, carbuncle and malignant swelling, plague poisoning, beriberi caused by wind toxins, toxic fever, and pyretoxin formation, which expanded the scope of application of the method of clearing heat and detoxifying. Song During the Jin Dynasty, Liu Hejian proposed "cold and cool to treat warmth" while establishing the theory of fiery heat, and formulated many prescriptions for clearing away heat and detoxification. After the Ming and Qing dynasties, Wu Youke, Yu Shiyu, Ye Tianshi, Xue Shengbai and other people with febrile disease They all explained the meaning of warm heat and evil toxins from different angles. The legislative treatment is especially focused on venting heat and detoxification, which broadens the scope of the treatment of febrile disease by clearing away heat and detoxifying methods.
Sophora flavescens
The treatment method for eliminating fire and toxins, the etiology is mainly designed for the three major diseases of epidemic poisoning, heat accumulation to poison, and fire poisoning endogenous. It mainly treats sores, , diarrhea, fever, diarrhea, and insect bites. , Cancer, acute fever and other diseases. Commonly used prescriptions are: Huanglian Jiedu Decoction, Xiexin Decoction, Gardenia Golden Flower Decoction, Qingwen Baidu Decoction, Lianggesan, Puji disinfection drink, Xianfang Huoxing drink, Wuwei disinfection drink, Si Miao Yongan Decoction, etc., are widely used in the treatment of internal and external diseases, women, children, miscellaneous diseases and emergencies.
Discussion on the essential connotation of heat-clearing and detoxifying method
Heat-clearing and detoxifying method, which is a method of clearing away heat and toxin by using drugs that have both "clearing heat" and "detoxifying" effects. It belongs to both the clearing method and the detoxifying method. There are a wide range of clearing methods. In addition to clearing heat and detoxification, there are clearing heat and purging fire, clearing heat and drying dampness, clearing heat and cooling blood, and clearing deficiency heat. The clearing method is used in conjunction, such as warming evil to attack the guard, it will relieve the guard and detox; if the heat enters the qi, the clearing and detoxification; the heat entering the camp, the clearing and detoxification; the heat entering the blood, the cooling blood will detoxify.The scope of detoxification is also very wide. In addition to clearing away heat and detoxification, detoxification can also be achieved by inducing vomiting, diarrhea, diuresis, and sweating. The drugs include emesis, anti-poisoning, insecticide and antipruritic drugs, and detoxification and detoxification. Muscle medicine, etc. Therefore, simply equating the heat-clearing and detoxifying method with the heat-clearing and detoxifying method or conflating it with the heat-clearing and detoxifying method and the detoxifying and swelling method are narrow or one-sided.
What "toxin" does the "clearing heat and detoxification" method solve? The classics of traditional Chinese medicine in the past are mostly summarized and extended from the clinical manifestations, but lack of micro-mechanism research. Many recent studies have confirmed that the heat-clearing and detoxification prescriptions can not only detoxify "extrinsic toxins", that is, bacteria, viruses and endotoxins, but also detoxify "endotoxins". Source-derived toxicity", that is, oxygen free radicals and inflammatory cytokines, such as the ethanol extract of dandelion and the total alkaloids of Coptis chinensis have antioxidant effects.
heat-clearing and detoxifying method
in the application of TCM oncology
The pathogenesis of the tumor is based on the deficiency and the real, that is, the whole body is "deficiency", the local is "real", and the internal heat toxin is " The main pathogenesis of "real". Gaiyin blood condenses into blood stasis when it encounters heat, and phlegm is condensed when body fluid meets heat. For example, "The Treasures of Wei Ji" in the Song Dynasty pointed out: "Cancer disease is onset, but there is no clue, it is just fleshy pain." Caused by fire and poison in the heart and spleen".
Tumor-related inflammation is closely related to fire and toxins, such as necrosis, ulceration or even infection in the late stage of the tumor, often with local red, swelling, heat and pain and general fever, thirst, red urine, constipation and other fever symptoms: such as rectum Cancer, pus and blood in the stool, redness, swelling, heat and pain in the anus, vomiting and spotting of leukemia, persistent low-grade fever, etc., are all manifestations of fire poisoning. Studies have confirmed that the inflammatory microenvironment is an important factor in promoting cancer metastasis, and the use of heat-clearing and detoxifying methods to eliminate tumor-related inflammation can achieve the purpose of controlling tumor development.
The heat-clearing and detoxifying method has synergistic and detoxification effects on tumor radiotherapy, hyperthermia and other local treatments. After radiotherapy, the body often exhibits pathogenic manifestations of fire evil and heat, such as local redness, swelling, heat pain, high fever, and limb twitching , Stiff neck, etc.,The use of heat-clearing and detoxifying methods combined with nourishing yin and nourishing body fluid, nourishing yin and moisturizing the lungs, is of great benefit to alleviating the damage of radiotherapy. Similarly, tumor hyperthermia such as radiofrequency ablation, microwave hyperthermia, ultrasound focusing, radioactive seed implantation, etc., cause normal tissue damage similar to "heat toxin" and "fire evil" invasion, and clinical use of heat-clearing and detoxifying methods Relieve symptoms such as fever, thirst, constipation and local damage.
For half a century, our country has carried out anti-tumor screening and pharmacological research on more than 3,000 kinds of Chinese medicines and nearly 300 compound prescriptions. Most of the Chinese medicines that have direct anti-cancer effect and have been clinically verified are antipyretic and antidote. Such as Chonglou (including the total saponins of Chonglou), Rubescens (including oridonin), and Mushroom (including colchicine) and so on. Heat-clearing and detoxifying drugs can exert resistance through various ways such as inhibiting cell proliferation, inducing cell apoptosis, differentiation and reversal, regulating the body's immune level, regulating cell signaling pathways and conduction, resisting gene mutations, inhibiting tumor angiogenesis, and anti-multidrug resistance. Tumor effect.
Chonglou
"cancer toxin" essence and ten methods of detoxification and treatment of cancer
can be called "cancer" including toxins that cause cancer growth and endotoxins that cause harm to the body after cancer grows. poison". Master of traditional Chinese medicine Zhou Zhongying believes that cancer toxin is a special toxin produced in the body during the occurrence and development of malignant tumors. It is violent, intractable, flowing, concealed and damaging. It is often associated with phlegm, blood stasis, and dampness. Pathological factors such as cementation exist, mutual cause and effect, both clamp transformation, and common disease.
The “toxin” that causes cancer is not only different from the evils of six evils, but also different from the evils of phlegm and blood stasis. Heat evil is related. According to the characteristics of "cancer toxin" which is biased towards heat and often interacts with phlegm, blood stasis, dampness and other pathological products, Professor Zhou Daihan's treatment mainly focuses on clearing away heat and detoxification, combined with the treatment of promoting blood circulation and removing blood stasis, removing phlegm and dispelling stagnation, etc. Combining the pathological characteristics of different cancers and the differentiation of the viscera and viscera, ten common anti-cancer and detoxification methods based on removing evil and detoxification are drawn up: Efficacy, suitable for patients with liver, gallbladder, pancreatic cancer and liver heat and blood stasis,Use gentian grass, aloe vera, Scutellaria barbata, dandelion, mountain gardenia, Yinchen, rhubarb, zedoary turmeric, bezoar, Bupleurum, white peony, Tian Qi, , , brook yellow grass , terrapin, etc.
gentian grass
Diaphragm detoxification method
has the effect of opening the diaphragm, detoxifying and promoting blood circulation, removing phlegm and relieving vomiting, suitable for esophageal cancer, mediastinal tumor obstruction, abdominal pain and vomiting For those who choose Gecko, Cockroach, Zhebei, French Pinellia, Southern Star, Jixue, Aesculus aegypti, dandelion, 威灵仙, ebony plum, 2span_span_span_span , Generation ocher, etc.
and stomach detoxification method
has the effects of harmonizing the stomach, detoxifying and removing blood stasis, relieving stagnation and relieving pain. It is suitable for gastric cancer, cardia cancer for those who cannot keep eating after food separation, abdominal pain and vomiting, choose Pinellia, turmeric , Zedoary turmeric, Tianqi, leech, Puhuang, Wulingzhi, Gallus gallus , Citrus aurantium, smilax, vine pear root, dandelion, etc. .
Intestinal detoxification method
It has the effects of rational intestinal stasis, dispelling dampness and detoxification, clearing the fu organs and stopping bleeding. It is suitable for intestinal cancer, peritoneal disseminated cancer, abdominal pain, diarrhea, and red white. Choose Sophora flavescens, Sophora japonica, honeysuckle, and ground Elm, Patriniacea, Oldenlandia diffusa, rhubarb charcoal, white peony, scutellaria, gall, poppy shell, agrimony, aloe, etc.
Honeysuckle
Tongqiao detoxification method
It has the effects of clearing the lungs, detoxifying and removing stagnation, eliminating phlegm and accumulating. It is suitable for patients with nasopharyngeal cancer, head and neck cancer, headache, bleeding, or neck mass pain. Pangolin, gecko, dew hive, stone cypress, sky kuaizi, cocklebur seed, prunus vulgaris, prunella vulgaris, mushroom, seaweed, mountain Kumbu and others.
Qingfei Jiedu method
has the effects of clearing lungs and relieving cough, detoxifying and removing phlegm, replenishing qi and eliminating symptoms. It is suitable for , bronchial lung cancer, thoracic tumors with phlegm and heat, shortness of breath and chest pain, choose houttuynia, Mulberry bark, earth bone bark, whole melon, reed stem, peach kernel, 葶苈子, zhebei, shougong, earth dragon, adenophora, asparagus, stone cypress, etc.
Gushen detoxification method
It has the effects of dispelling nodules in the kidney, detoxifying and removing blood stasis, cooling blood and diuresis, suitable for kidney cancer, , bladder cancer, prostate cancer, testicular cancer, urine leaching, blood in the urine, lower abdomen swelling For those who are in pain, choose Polyporus umbellatus, Solanum, Small thistle, Verbena, Plantain, Agrimonia, Scutellaria, Leech, Eucommia , Cornus, Morinda , Sheep Ye et al.
Verbena
Dispelling symptoms and detoxification method
It has the effects of soothing liver and detoxification, removing blood stasis and detoxification, dispelling dampness and dispelling lumps. It is suitable for breast cancer lumps, cervical cancer, uterine cancer, and ovarian cancer. For those with red, white, stinky, low-abdominal symptoms, choose agaricus, pangolin, dew honeycomb, angelica, Bupleurum, Prunella vulgaris, Aesculus vulgaris, Sophora flavescens, Curcuma turmeric, Diyu charcoal, Dragon's blood, snake Raspberry etc.
Phlegm-removing and detoxification method
has the effects of removing phlegm and dispersing nodules, detoxifying and removing stagnation, removing dampness and dredging collaterals, suitable for malignant lymphoma, soft tissue sarcoma weight loss and fever, hepatosplenomegaly, select soft-shelled turtle, soil soft-shelled turtle, centipede, silkworm, southern star, pinellia, turmeric, seaweed, kelp, forsythia, cat's claw, prunella, dandelion, oldenlandia diffusa, mountain mushroom, etc.
Cooling blood and detoxification method
has the effects of cooling blood to stop bleeding, clearing away heat and detoxification, removing blood stasis and eliminating symptoms. It is suitable for all kinds of leukemia or chronic leukemia acute patients. Choose Qingdai (for research and development), Shengdi, Danpi, Qiang Root, Agrimony, Blood Charcoal, Eclipta prostrata, Trichosanthes, Ophiopogon japonicus, Dandelion, Hedyotis diffusa, American ginseng, Liushen pill, etc.
American ginseng
The above enumerated ten common anti-cancer and detoxification methods, which are mainly created for the ten common cancers, and most of them are treated with heat-clearing and detoxifying Chinese medicines. The specific clinical treatment should not deviate from the purpose of syndrome differentiation, such as If the symptom is acute, it is advisable to treat the symptoms according to the principle of "emergency to treat the symptoms". If the constitution is weak and the breath is dying, and the cold is not allowed to attack, then the principle of "slowness will cure the root" should be adopted to strengthen the righteousness and eliminate the evil. , Or from the combination of attack to supplement theory. In short, when using the heat-clearing and detoxifying method to combat tumors, you must always take into account the righteousness and coordinate the relationship between the whole and the part, in order to achieve the purpose of "treating the disease and keeping people" and "surviving with the tumor." ■
[Content collated from: "China Journal of Traditional Chinese Medicine", May 20, 2016, fourth edition, author: Zhang Enxin and Hou Chao, First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine]
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