Pancreatic cancer: Most common malignant tumors, accounting for 1%-2% of systemic malignant tumors. It is more common in men, more common in those over 40 years old. It has high malignancy and is not easy to detect early. The low resection rate and poor prognosis are the characteristics of this disease. The 5-year survival rate of patients with resectable is less than 5% . It ranks fourth in the cause of death from malignant tumors. It ranks second in the cause of death from digestive tract cancer, second only to colorectal cancer, with a 5-year survival rate of 1%-3%.
Pancreatic head cancer involves duodenum, common bile duct, portal vein, mesenteric blood vessels, etc. Pancreatic head cancer involves duodenum, common bile duct, portal vein, mesenteric blood vessels, etc.
Pay attention to the following aspects:
(1) There are no specific symptoms in early pancreatic cancer
(2) Upper abdominal pain mostly manifests only as upper abdominal discomfort or dull pain, dull pain and swelling pain, etc. is very easy to be confused with the symptoms of gastrointestinal and liver and gallbladder diseases. Due to post-practice stimulation of bile-pancreatic secretion, outlet obstruction, and increased pressure in the bile-pancreatic duct, which can aggravate pain or discomfort;
(3) Loss of appetite or changes in dietary habits, abdominal distension, indigestion, diarrhea or constipation, especially not liking greasy and high-protein foods, which are another significant symptom. Advanced cancer invasion and duodenum may cause upper gastrointestinal obstruction or gastrointestinal bleeding.
(4) Jaundice is a characteristic symptom of pancreatic head cancer and is generally progressively aggravated. Due to the biological characteristics of peritubule infiltration of pancreatic cancer, jaundice can appear early. The color of the stool becomes lighter as the jaundice deepens, and finally becomes clay-colored. The urine color became thicker and thicker and soy sauce color. Most patients have itchy skin and scratches all over the body.
(5) Weakness and fatigue You can experience weight loss and fatigue in the early stage. Its outstanding feature is that the significant weight loss in is.
(6) A few patients have symptoms of mild diabetes.
(7) Mental neurological disorder: Some patients have depression, anxiety, mania, etc., among which depression is the most common.
Pancreatic tail cancer Pancreatic tail cancer
Early diagnosis is difficult, and most of the late stages have lost the opportunity for surgery. Therefore, those over 40 years old who have experienced the following clinical manifestations recently should pay attention to it:
① Persistent upper abdominal discomfort, worsening after meals and decreased appetite; unexplained symptoms of indigestion, endoscopy is normal. Sudden unexplained fatty laxative
② Unexplained progressive wasting; weight loss by 10%.
③Unexplained jaundice for unknown reasons.
④ Recently, unexplained upper abdomen or back pain
⑤ Unexplained Diabetes or diabetes suddenly worsen;
⑥ Multiple deep venous thrombosis or wandering phlebitis;
⑤ The onset of spontaneous pancreatitis. People with a family history of pancreatic cancer, extensive smoking, and chronic pancreatitis. Close follow-up examination should be conducted.
diagnostic process
Treatment aspects: 1. Surgery. Pancreatic head duodenectomy (Whipple surgery) is a surgical method for treating this disease.
2. Chemotherapy . systemic chemotherapy; transarterial interventional chemotherapy; local injection of drug chemotherapy. Various combination chemotherapy mainly consists of gemcitabine are currently the only first-line solution recommended by the medical community. Most current research results show that the efficacy of gemcitabine combined with 5-fluorouracil chemotherapy is not significantly higher than that of gemcitabine chemotherapy alone.
3. immunotherapy .
4. Gene therapy
