Xiao Zhang, who is in his 20s, is a takeaway worker. Due to the nature of his work, he needs to travel outdoors for a long time every day. In order to make some money, Xiao Zhang delivers more than 10 hours of takeaway every day, so he feels tired and exhausted every time after get off work. The weather has become cold recently, but Xiao Zhang still works outside for a long time in order to make money, regardless of the weather.
3 days ago, Xiao Zhang suddenly found that he would leak when drinking water. After looking in the mirror, he found that his face was crooked and his left eyelids drooped. He was afraid that had stroke , so he hurried to the hospital for examination . After he had a CT scan for the brain, the doctor found that there was nothing abnormal. After a systematic neurological examination, Xiao Zhang was finally diagnosed with peripheral facial nerve paralysis, and he was prescribed hormones, depazole and methylcobalamin, and told Xiao Zhang not to work anymore recently and take the medication regularly and regularly and regularly.
Xiao Zhang would take the medicine according to the doctor's instructions and did not find any effect. Instead, he found that he became prone to sweating and had mild headaches. He was afraid that the treatment effect of the medicine was not good, so he hurried to the hospital for consultation. The doctor examined and explained to Xiao Zhang that the treatment cycle of peripheral facial paralysis is about 2 weeks, and Xiao Zhang is still in the acute phase, so he needs to take it for a while, and Xiao Zhang becomes prone to sweating and headaches. This is actually one of the side effects of depazole, but there is no need to stop the medicine, just reduce the dosage appropriately. . So after the doctor adjusted the medication plan for Xiao Zhang, Xiao Zhang's adverse reactions were indeed much better. After about 2 weeks of continuous treatment, Xiao Zhang's facial paralysis gradually recovered.
1. Mechanism and characteristics of depazole
Depazole is one of the commonly used muscle relaxants in clinical practice. has a significant inhibitory effect on smooth muscle, especially on vascular smooth muscle and digestive tract smooth muscle , etc. . It is often used in clinical practice to prevent and treat peripheral facial nerve paralysis, cerebral blood supply , cerebral infarction , gastrointestinal spasm, mild hypertension and other diseases . It is widely used in clinical practice, but due to its complex mechanism of action, it will also cause a variety of adverse reactions if used improperly. The mechanism of action of
depazole is relatively complex. It not only has a significant loosening effect on peripheral smooth muscle, but also can act with central nervous system . Therefore, it is often used in clinical practice to treat various central system diseases.
First, Depapazole has a significant effect on the tense smooth muscle . Pharmacological studies have shown that depazole has a similar effect as a calcium ion channel antagonist. It can bind to calcium ion channel indicated by smooth muscle to block the inflow of calcium ion , thereby effectively relieving spasm of smooth muscle. This effect is most obvious to the blood vessels and gastrointestinal tract of the head and face. Depazole can effectively relieve vasospasm, thereby improving blood supply to the head and face. At the same time, it can also relieve the spasm of the gastrointestinal tract and relieve abdominal pain, bloating and other discomforts caused by gastrointestinal spasm.
Second, Depalazole has mild excitatory effects on the central nervous system. Pharmacological studies have shown that depazole can act on the central nervous system and regulate the metabolism and secretion of central neurotransmitters. , especially the metabolism of 5-hydroxytryptamine , thus leading to the accelerated metabolism of serotonin and a certain central nervous excitation effect. This has led to a clinical manifestation of decreased sleep quality after taking depazoleptazole.
Finally, Depapazole has a certain antihypertensive effect . Depazole can reduce blood flow back by diastolic peripheral blood vessels to achieve the purpose of lowering blood flow , but this antihypertensive effect is very weak. Since depazole is metabolized quickly in the human body, it often requires large doses and multiple doses to achieve the effect of lowering blood pressure. is only used as a preventive drug for mild hypertension in clinical practice, or used in combination with other types of antihypertensive drugs.
2. Depazole can treat these four diseases.
Depazole has a wide range of clinical applications, mainly vasospasm and gastrointestinal spasm diseases. However, the dosage and methods of depazole are different when treating different diseases. It is necessary to pay attention to the individualized medication for different patients. Clinically, depazole is often used to treat the following four diseases.
1, mild hypertension
clinical mild hypertension refers to hypertensive patients with systolic blood pressure of 140-159mmHg, and (or) diastolic blood pressure of 90-100mmHg. This type of patients are clinically mild hypertensive. In combination with other diseases (so hyperlipidemia, stroke , etc.), it does not advocate the use of first-line antihypertensive drugs, but can be treated with depazole. The clinical treatment of mild hypertension is 10-20 mg each time, 3 times a day, which can effectively lower blood pressure, and there will be no obvious hypotension reaction .
2, gastrointestinal cramps
3 Gastrointestinal cramps are one of the common digestive system diseases in clinical practice. They are a kind of abdominal pain, bloating and other discomfort caused by violent contraction of the gastrointestinal tract. They are common in children, especially after taking cold and irritating foods. Dipazole is a common medicine for clinical treatment of gastrointestinal cramps. clinically takes 10-20 mg each time when treating gastrointestinal cramps, 2-3 times a day, which can quickly relieve gastrointestinal cramps and relieve abdominal pain .
3, peripheral facial nerve paralysis
depazole is one of the common drugs for the treatment of peripheral facial nerve paralysis. Its main function is to dilate the blood vessels of the facial facial, enhance the blood supply of the facial facial, and accelerate the recovery of the facial nerve. It is often used in clinical practice with hormones, methylcobalamin and other drugs. clinically treats peripheral facial nerve paralysis 5-10 mg each time, 3 times a day, and continuously for 2-4 weeks, which can effectively improve facial blood supply and improve facial function .
4, insufficient blood supply in the brain
3 Vasospasm is one of the common causes of insufficient blood supply in the brain. Vasospasm causes stenosis of the arterial lumen, especially the carotid and vertebral arteries, which leads to insufficient blood supply in the brain. It is mostly manifested in dizziness, headache, insomnia, forgetfulness, etc., and chronic insufficient blood supply in the brain can easily lead to central system diseases such as brain atrophy and stroke. is often used in clinical practice to prevent and treat insufficient blood supply in cerebral blood supply. The method of taking is 5-10 mg each time, 3 times a day, which can effectively relieve the spasm of the blood vessels and significantly improve the blood supply of the brain .
3. These three types of people should be cautious when using depazole
depazole itself is safe and has fewer adverse reactions under standardized use. However, due to its complex mechanism of action, you must be cautious when using special groups, especially the following three groups.
1, hypotensive people
depazole has the effect similar to calcium channel blockers (such as nifedipine, amlodipine , etc.), which leads to it being able to dilate peripheral blood vessels and lead to low blood pressure. Although this effect is weak, may cause further blood pressure to drop, thereby inducing adverse manifestations such as dizziness, nausea, unstable standing, fainting, etc. Therefore, people with hypotensive people must monitor blood pressure changes when taking depazole and start from low doses.
2, insomnia
3 Depazole has a certain excitatory effect on the central nervous system, so a small number of patients are prone to decline in sleep quality after taking depazole. Therefore, for people who have suffered from insomnia in the past, insomnia is prone to worsening insomnia after taking depazole. In this case, the dosage of depazole needs to be adjusted, and combined with vitamins and other drugs to promote sleep, , which can be tolerated after taking it for a period of time.
3, Migraine people
Overdiplomatic blood vessels in the head and face is one of the main pathogenesis of migraine, and the main function of depazole is to dilate the smooth muscle of the head and face blood supply to improve the head and face blood supply. therefore has a certain chance of inducing migraine recurrence, leading to severe clinical reactions such as headache, nausea, and vomiting. At this time, you should suspend the use of depazole and wait until the migraine symptoms are controlled before taking .
4. Pay attention to 4 points for taking dipazole scientifically
Dipazole is a common medicine for the treatment of peripheral facial nerve paralysis and insufficient cerebral blood supply. It is safer itself, but it is still recommended that patients in need take the medicine under the guidance of a doctor. Pay attention to the following 4 points for taking dipazole scientifically.
First, pay attention to the dosage of the drug and the method of taking
Delpazole has different medication plans when treating different diseases. When treating hypertension and gastrointestinal cramps, the dose is larger each time, about 10-20 mg; when treating peripheral facial nerve paralysis and insufficient blood supply to the cerebral, the dose is smaller each time, about 5-10 mg. Secondly, since depazole is metabolized rapidly in the human body, often requires multiple doses to have obvious effect. The number of doses per day is 2-3 times .
Second, pay attention to the side effects of the drug
Depalazole has a certain effect on peripheral blood vessels and Central nerve , so it may cause a variety of adverse reactions when taken. Among them, is sweating, flushing complexion, and headache. This is because depazole has a significant diastolic effect on the blood vessels of the head and face, but does not affect the use of medicine, and most of them can tolerate it. Secondly, a very small number of patients with will experience a decrease in sleep quality after taking medicine. In this case, vitamins, melatonin and other treatments can be used to help improve sleep. Finally, depazole has a certain impact on blood pressure, especially for patients with hypotension, which is easy to aggravate the hypotensive reaction. Therefore, Chinese medicine monitors blood pressure changes during the medication.
Third, pay attention to the medication for special groups
Pregnant women and lactating women are prohibited from using , lack of safety data; elderly people use it with caution, and need to start from small doses, pay attention to changes in blood pressure ; children are prohibited from using , lack of relevant research data; drug allergic to use .
Fourth, pay attention to the combination medication
Delpazole needs to be combined with hormones, methylcobalamin and other drugs when treating peripheral facial nerve damage, because depazole itself does not have the effect of nourishing nerves, but is only used as a combination therapy drug; secondly, when local pazole is combined with antihypertensive drugs, you must monitor blood pressure to prevent hypotension .
5. Summary
To sum up, depazole is a common medicine to prevent and treat peripheral facial nerve paralysis, gastrointestinal cramps, and insufficient blood supply in cerebral blood supply. However, it cannot be used at will. You must pay attention to the dosage and usage of the medicine. It is recommended that patients in need take the medicine under the guidance of a doctor; secondly, you must pay attention to the adverse reactions that may occur during the medication, and respond to the doctor in time after discovery.
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