When it comes to rare blood type , everyone will think of RH-negative "panda blood". But there is also a type of blood type is more rare than panda blood , and it is called "dinosaur blood", that is, the Mumbai-like blood type.
It is reported that this type of blood type was first discovered in Mumbai, India in 1952, and is extremely rare in China. The proportion of people with this type of blood type in the country is only one in a hundred thousand, and there are only more than a hundred cases in the country. Because this type of "Mumbai-like blood type" is very rare, its value and significance are particularly significant.
Recently, a Mumbai-like blood type was found in the Laboratory Department (Hematotransfusion Department) of Changsha Fourth Hospital.
Not long ago, a minority pregnant mother visited at , Changsha Fourth Hospital. During the diagnosis and treatment process, Liu Qianxi, deputy chief examiner, found that the positive and negative blood type of the pregnant woman did not match the positive and negative blood type. The positive and negative blood type showed that the positive blood type of B type feature, which was positive for screening and negative for itself. The abnormal result immediately aroused her high vigilance and immediately contacted the pregnant woman to find out the situation. According to reports, the pregnant woman gave birth to her first two babies in an outer hospital and her blood type was O type . Liu Qianxi immediately reported the situation to the department director Zhang Biming, who organized the department to conduct in-depth research on this difficult blood type. After review of different related blood types such as anti-H, saline anti-sieve method, absorption and dispersion experiment, microcolumn gel method, test tube method, etc., the serological experiment was initially considered as Mumbai-like blood type.
In order to ensure the accuracy of the test results, Director Zhang Biming led the blood transfusion department personnel to continue to read a large amount of information and consulted blood transfusion experts at home and abroad. The experts recommended blood type gene testing. Due to the limited testing conditions of the hospital and the actual blood type of the pregnant woman, after fully communicating with the pregnant woman, Liu Qianxi contacted West China Hospital for free for the pregnant woman to perform blood type gene testing. On October 11, the final result returns: the patient's serology is Mumbai-like type B. The sequencing results of the FUT-1 gene comply with the FUT1*01W.37 (weak expression of H antigen) published by the ISBT International Society of Transfusion. The sequencing results are shown as FUT1*01W.37//FUT1*01W.37. The results of ABO gene sequencing are in line with B101/O02 published by the ISBT International Society of Transfusion. The patient's gene expression was normal B glycosyltransferase activity, and the ABO glycosyltransferase gene mutation was excluded to lead to ABO subtype. Zhang Biming, director and chief technician of the Laboratory Department (Hematopoietic Transfusion Department), introduced that people with Mumbai blood type usually have a pair of regulatory genes ZZ, which partially inhibits the H gene's H antigen formation on red blood cells , but does not affect the synthesis of H substances in saliva. Therefore, H antigen is generally not found on red blood cells like Mumbai, but only a small amount of A or B antigen. In addition to anti-A and anti-B antibodies, there are also anti-H antibodies in the serum, and A or B antigens can be found in saliva. Therefore, if this group of people needs blood transfusion, it is difficult to find matching blood. The general ABO blood type cannot be detected as Mumbai-like blood type. If it is not further detailed, it is easily mistaken for O blood type . The best way to identify Mumbai-like blood type is to check whether there is H antigen in the blood, so that it can be accurately detected.
For pregnant women with rare blood types, once severe bleeding or other blood loss occurs during the operation, they will face the dilemma of no blood to be transfusion. This type of people should pay special attention to their own health and safety in their daily lives. When such people need blood transfusions, it is best to undergo autologous blood transfusion or infusion of blood lacking homotype H antigen. It is recommended to store their own blood in advance. When emergency blood transfusion is required without the same type or without autologous transfusion, the ABO homotypic blood that does not respond to the patient's serum or the weakest response should be first injected to minimize the risk of hemolysis. During the infusion process, it is necessary to closely observe whether adverse blood transfusion reactions occur to fully ensure that the patient can undergo blood transfusion treatment safely and effectively.
Xiaoxiang Morning News Reporter Mei Mei Correspondent Liao Yingna
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