"New discovery! Intestinal flora may cause autism?"
Research on the intestinal flora has become more and more popular in recent years. The occurrence and development of many diseases can be used to study the distribution of intestinal flora. . People began to compare the flora of children with diarrhea and those without diarrhea, and compare the intestinal flora of diabetic and non-diabetic children, and so on.
Recently, there have been reports that the intestinal flora may be related to autism (also known as autism). Of course, the author is also very rigorous and did not conclude that the intestinal flora is the cause of autism.
The research on intestinal flora focuses more on digestive diseases such as the gastrointestinal tract. Many studies have also found that supplementing the appropriate flora (there are many types, and the flora involved in various studies are different), and it can also relieve children's diarrhea, constipation, abdominal pain and other digestive diseases, as well as related allergies and other problems. effect. However, the effect of supplementing the flora is not consistent in many studies. After
, with the development of various theories related to brain development. It has been suggested that abnormal intestinal-brain axis may affect the development of the brain, which may lead to various developmental disorders (such as autism).
❖ A review in 2015 suggested that immune disorders, gastrointestinal inflammation, autonomic nervous system dysfunction, changes in intestinal flora and food metabolites may cause brain nerve inflammation and dysfunction.
❖ A review in 2016 stated that abnormalities in the enteric nervous system may play a role in neurological diseases such as autism. Neural connections and the immune system are a route that may allow diseases from the gut to spread to the brain.
Therefore, some scientists have invested in related research and made some discoveries. Today, I will analyze 5 rumors about the treatment of intestinal flora.
Author | Ji Ning
Organizing & Editing | Hi Nao Ren
No
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01
The relationship is not necessarily a causal relationship
Rumor: Intestinal flora dysbiosis has caused autism
, we can't tell the rumors
10z
↓ Disorder is the cause of disease or the result of disease.
For example, we are comparing people who have a cold with those who don't. What is the difference in the frequency of coughing? Obviously, people who have a cold will cough more. This is "correlation", indicating that a cold and a cough are related. However, we will not say that the cough caused the cold.
When we compare the intestinal flora of autistic and non-autistic children, if we find a difference, we will not immediately say that it is the difference in intestinal flora that causes autism. Because, it is also possible that eating disorders in children with autism may cause differences in intestinal flora.
No
-Number-
02
What is "intestinal flora imbalance"?
Rumor: Intestinal flora imbalance is a disease
rumor ↓
There is no definition of intestinal flora imbalance.
The intestinal flora is the normal microbes of the human intestines, such as bifidobacteria, lactobacillus, etc. can synthesize a variety of vitamins necessary for human growth and development, such as B vitamins (vitamins B1, B2, B6, B12), vitamin K, Niacin, pantothenic acid, etc., can also use protein residues to synthesize essential amino acids, such as aspartic acid, phenylalanine, valine and threonine, etc., and participate in the metabolism of carbohydrates and proteins, and also promote iron The absorption of mineral elements such as, magnesium and zinc. These nutrients play an important role in human health.
Unfortunately, there is no accurate and accepted definition of "intestinal flora imbalance". According to the number of cultivable bacteria, it is classified in the intestinal flora. There are more than 400 kinds of bacteria that can be cultivated. Different regions, different eating habits, and different ages will affect the distribution and quantity of intestinal flora, and they may all be normal. Therefore, it is difficult for us to define what kind of flora distribution is abnormal and unbalanced.
No
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03
How do you view the dazzling variety of research results?
rumors: The results suggest that we need to use intestinal flora to treat
as soon as possible
to refute rumors ↓
scientific researchIt takes time and long-term demonstration to reach the first-line application.
is like we need to launch a spacecraft to Mars now, scientific research may not be reflected in daily life immediately. Many researchers of intestinal microbiota also adhere to a rigorous scientific attitude, and will not put microbiota treatment in the formal "treatment guidelines" until causality can be obtained. After all, treatment guidelines are the basis for all our doctors to prescribe treatment.
The most widely circulated example of evidence-based medicine in the medical field is the incident of thalidomide.
Some treatments are used blindly before undergoing rigorous review in Phase IV clinical trials, which is risky.
"What is a "thalidomide" event?"
In the 1960s, doctors in at least 15 countries in Europe and the United States were using "thalidomide" to treat women's pregnancy reactions. Many people did not vomit after taking the medicine, and it was nauseating. The symptoms have been significantly improved, so it became an "ideal choice for pregnant women" (the advertising language at the time).
As a result, "Thalidomide" is mass produced and sold. In the Federal Republic of Germany alone, nearly 1 million people have taken "Thalidomide", and the monthly sales volume of "Thalidomide" reached 1 ton. In some states in the Federal Republic of Germany, patients can even purchase thalidomide without a doctor's prescription.
But what followed was that many babies were born with short limb deformities, similar to seals, called "seal limb deformities." In 1961, this symptom was finally confirmed to be caused by pregnant women taking thalidomide. As a result, the drug was banned, however, as many as 12,000 babies have been affected by it. How does
No
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04
regulate ethics?
Rumor: Since there are big experts doing cutting-edge clinical trials, then we can widely use
to dispel rumors↓
big experts will respect ethical norms, and the patient will sign an informed consent form, which will be completed under the guidance of relevant authorities Clinical Trials.
can reveal to parents a distinction between true clinical trials and "scams of selling drugs in clinical trials", that is, formal clinical research. An informed consent form will be signed with you to inform you of the risks and possible benefits you are taking. The right to stop participating at any time.
However, those who recommend drugs and health products that are "not in the guidelines" to parents for "trying" use without signing an informed consent are very risky.
No
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05
Can I try it?
Rumors: For treatments that are not in the guide, you must not use
to dispel rumors. ↓
After you weigh the risks and benefits, you can participate.
We also often advise parents that if their children are already undergoing systemic, comprehensive, behavioral intervention-led education rehabilitation, it is not impossible to try some new treatment methods in addition to behavioral intervention.
It is absolutely undesirable if you easily believe in "remedies", "magic curative effects", and "cure" treatment methods, and give up formal behavioral interventions.
Today's topic
There are many therapies on the market that claim to "curable autism", which ones have you heard of? Have any questions? You can leave a message to tell us.
Or, what unreliable treatments have you personally experienced, it is better to tell the parents of Xingbao to avoid the pit~ See you in the comments section at
!
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