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"It has been 4 years since I was running around the road, the pain of injections, and the blow of failure have made me physically and mentally exhausted. In those dark days, I was particularly confused and confused, and I could not see any hope. I once thought about giving up. But when I really wanted to give up, the tenacity of not believing in evil and not giving up again and supporting us. Why can't I do it, why can't I? I just don't believe it! Finally, my husband and I reached a consensus that as long as we have not reached the moment of despair, we will not give up..."
The sad words hidden deep in my heart for many years, Yingying finally said it all. She is a "strong general" among many elderly women of childbearing age who have gone from natural pregnancy preparation without success in turning into an IVF journey. upgraded and fought "monsters" all the way on the road to test tubes, and withstood the hardships of "five promotions and ten transfers" (5 egg induced ejaculation and egg retrieval, 10 embryo transfers), withstood the pain caused by countless transplant failures, and endured the mental torture that ordinary people could not understand, and finally successfully became pregnant.
One and four years of pregnancy persistence, and finally got surprises
A few years ago, Yingying and her husband planned to prepare for a second child, but there was no movement for a long time. So various examinations were conducted in the local hospital of Zhaoqing , and the results were diagnosed as secondary infertility and moderate weak malformation spermosis . The doctor had no choice but to tell that it was difficult to get pregnant naturally.
"Crash, it's really something that happened in a moment." , recalling the situation at the beginning, Yingying felt like she was a different life.
Since then, Yingying and her husband have begun to turn to test tubes. Considering that the medical conditions in provincial capitals are better and the success rate should be relatively higher, they chose to travel back and forth between Guangzhou.
IVF refers to a baby born by artificial methods to fertilize egg cells and sperm in vitro, and transplant them into the maternal uterus after early embryonic development.
However, harvest and effort are not necessarily equal. On the way to seek medical treatment, Yingying had to get up at less than 6 o'clock in the morning every day and drove for at least 3 hours. She had not started treatment when she arrived at the hospital and was a little tired. During that period, I experienced egg retrieval and embryo transfer in the hospital in total; each cycle was like a marathon, but the end was out of reach, and the couple also felt hopeful from the beginning to the later feeling desperate.
"Whenever we want to give up, we will think about why others can, why can't I? I just don't believe it! In the end, we married and agreed to reach a consensus. As long as we have not reached the moment of despair, we will continue to persevere..."
Fortunately, this persistence has won victory.
"Discovering a doctor is the same as love. You need to find the right person at the right time." Yingying looked back and saw that when she learned from relatives and friends that Ma Wenmin, deputy chairman of the Reproductive Medicine Branch of the Guangdong Medical Association, came to Zhaoqing, a woman's sixth feeling flashed quickly - go to Xijiang again to try it! Yingying believes that "I have experienced the pain and difficulties of the previous nine transplant failures, and this time it is not bad. I want to try another shot."
The heavens pay off. On the last test tube line, after examination and evaluation, Yingying was very lucky - egg retrieval was obtained at one time, and one transplant was successful. fetal heart rate was measured 1 month after the transplant. There is still about a week before the expected delivery period, and Yingying will soon be able to meet the second baby.
◎ Good news finally came on the last test tube. / Zhaiku Heluo PLUS
Now, for Yingying, all the hardships on the journey of 4 years of hardships are now in a joke, and Yingying's face is filled with joy and happiness that others can feel.
2. Do test tubes: Successful in one go, is it lucky
Why do some people get pregnant successfully after doing test tubes?
Why do some people succeed after doing test tubes three times?
Why do some people fail to succeed in 3+ times?
...
Too many "whys" point to a factor- IVF success rate . Ma Wenmin (an expert in Guangdong Assisted Reproductive Technology Quality Management Center, deputy chairman of the Reproductive Medicine Branch of the Guangdong Medical Association, director of Zhaoqing Xijiang Hospital and head of the Reproductive Center) said that the average success rate of test tubes in my country is about 50% , but whether the test tube baby can be successful has a certain relationship with the number of assisted pregnancy. After multiple embryo transfers, the cumulative pregnancy rate of test tube baby will increase.
Let’s first look at a set of data:
From the chart, we can see that the success rate of a single transplant is about 40%, the success rate of two IVF treatments is about 62%, the success rate of three IVF treatments is about 79%, and the success rate of four IVF treatments is about 90%.
Why do some people "failure to repetitive transplants"?
First of all, there is no unified definition for "repeated transplant failure", but now it is generally recognized that it refers to more than 3 embryo transfers or cumulative transplants of more than 4 high-quality embryos, but none of them successfully conceived.
The influencing factors include: the occurrence of repeated transplant failures, which may be caused by single factors or by the joint influence of multiple factors, and some may be unknown.
"mainly consider the comprehensive considerations of embryonic factors and maternal factors." Ma Wenmin pointed out.
Embryonic factors mainly include : embryonic genetic material defects, embryo hatching and poor development potential; and other related factors (clinical management and quality control, laboratory management and quality control), etc.
Maternal factors includes: immune factors, tendency to thrombosis, abnormal anatomical structure, abnormal development and function of endometrial , frequent uterine contraction, endocrine factors, maternal psychological factors, etc.
◎ After 4 years of hardship, Yingying successfully got pregnant with her second child. During her pregnancy, she came to the hospital to thank Director Ma Wenmin. / Photo provided by the hospital
So, how can improve the success rate of embryo transfer?
Ma Wenmin pointed out that on the one hand, it is to process it from the embryo side, such as:
1, blastocyst culture : Patients who have not transplanted multiple high-scoring embryos without pregnancy can consider blastocyst culture for further screening Select embryos;
2. Do genetic screening before embryo implantation : Because embryonic chromosomal aneuploidy is one of the important reasons for the failure of embryo transfer;
On the other hand, the original ovulation induction plan is adjusted to improve the quality and quantity of egg acquisition. And other auxiliary measures: for example, the use of growth hormone , the use of weak androgens, lifestyle adjustment, etc.;
In addition, patients who fail to recurrence transplantation can also choose to perform hysteroscopy . Sometimes some abnormalities that cannot be displayed on B-ultrasound can be found, thereby increasing the chance of implantation ;
In addition, it can improve the receptivity of endometrium, regulate the local internal environment of the endometrium, and promote embryo implantation.
In short, "Repeated embryo transplantation is a headache for patients and doctors." , Ma Wenmin admitted that doctors will vary from person to person and adopt individual treatment plans, "The goals of doctors and patients are highly consistent, and they both hope to succeed in one go."
(At the patient's request, Yingying in the article is a pseudonym)
Author｜Director and head of the Reproductive Center of Zhaoqing Xijiang Hospital and Director of the Reproductive Center Ma Wenmin
correspondent｜ Cheng Lifeng
Editing｜ Liao Yingyao
Editing｜Wang Huiming
Editing｜Wang Huiming
