With the aging of the social population, the number of patients with Alzheimer's disease has increased significantly. Not only does the patient's quality of life decline, it also puts considerable caregiving pressure on the family. Since Alzheimer's disease is irreversible and dr

With the aging of the social population, the number of patients with Alzheimer's disease has increased significantly. Not only does the patient's quality of life decline, it also puts considerable caregiving pressure on the family. Since Alzheimer's disease is irreversible and drug treatment has little effect, how to accurately determine its preclinical stage and ultra-early intervention to prevent it has become crucial.

Today, a major national scientific research project led by Professor Xu Yun, Director of the Department of Neurology, Drum Tower Hospital Affiliated to Nanjing University School of Medicine - "Research on the New Mechanism of Alzheimer's Disease Transformation and Its Early Warning and Intervention System" was officially launched, with project funding of 5955.1 With RMB 10,000, the team will move the prevention and treatment frontier forward by further studying the onset and intervention mechanisms of Alzheimer's disease.

data shows that there are about 9.83 million Alzheimer's disease patients in my country among the elderly aged 60 and above, accounting for 25%-30% of the global patients. Since it is irreversible, early detection and intervention are key. Xu Yun, director of the Department of Neurology at Nanjing Drum Tower Hospital, said, "Alzheimer's disease (AD) has two stages in the early stages, namely subjective cognitive decline (SCD) and mild cognitive impairment (MCI). That is It was said that the patient himself felt memory loss , but when he went to the hospital for examination, it was normal."

According to experts, the incidence rate of subjective cognitive decline over the age of 65 is 25%-50%; the incidence rate of subjective cognitive decline over the age of 85 is 88%. The 2-year average conversion rate of subjective cognitive decline to mild cognitive impairment is 17-37%, and that of mild cognitive impairment to Alzheimer's disease is 13.4-38%. "Before the pathological changes, there are abnormalities at the starting node of axons. The abnormalities can actually be changed, so our team is now working to overcome this relationship."

as a scientific and technological innovation 2030 " Brain Science and One of the major projects of "Brain-like Research", the team can promote the development of detection kits, related therapeutic drugs and programs through the study of relevant mechanisms. Xu Yun introduced that in daily life, symptoms such as memory loss are generally divided into two types: physiological and pathological. Physiological forgetfulness is normal, but if it is pathological, it needs to be taken seriously. "If we use detection kits, we can predict whether there is a possibility of transformation to AD (Alzheimer's disease). We have also designed some digital drugs that use computers to play games to allow patients to train, reduce and prevent ACD. (Subjective cognitive decline) to AD (Alzheimer’s disease).”

Xu Yun introduced that the prevalence of Alzheimer’s disease in people over 60 years old is as high as 2 to 5%, and it increases with age. "For example, he himself has this subjective cognitive concept, and people who are particularly anxious are relatively high-risk. Second, these patients may have some high-risk factors, such as hypertension , diabetes , and apnea syndrome. Diseases, etc., when such groups come to the hospital, they can be screened to determine whether they are likely to transform into AD (Alzheimer's disease)." (Source: Jiangsu Radio and Television Media News Center/Wang Xuetong Editor/Yu Jie)

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