On March 25, 2022, the PD-1 inhibitor H drug Hansi, developed by Shanghai Henlius, was approved for marketing by the National Food and Drug Administration. This is also the first "pan-cancer" PD-1 to be marketed in my country. 1 inhibitor. It is mainly used to treat advanced solid cancer tumors that have been treated with ordinary surgery, , radiotherapy, chemotherapy, and other traditional therapies that have no obvious effect.
"Pan-cancer" actually means that this drug targets a variety of common cancer tumors rather than a single tumor . It can cover lung cancer, gastric cancer , esophageal cancer and other malignant tumors Including cancer , it brings better treatment methods and new hope to patients with advanced cancer, helping patients to better extend their lives.
Why is this drug so miraculous and able to fight many types of cancer? This is about the relationship between cancer and cancer cells.
Where does cancer come from? There are many factors that may cause cancer, family history, smoking and drinking, long-term inflammation stimulation and so on. However, without exception, cancer is naturally inseparable from cancer cells. A large number of cancer cells proliferate crazily to form severe malignant tumors , which is what we often call solid cancer.
Ordinary people may also have cancer cells in their bodies. I believe many people cannot believe it, but in fact it is true. About 10,000 cancer cells are generated in each of our bodies every day. Many people have different levels of tumor markers when testing , but cancer has never been diagnosed solely based on tumor markers . This is because there may also be cancer cells in our normal bodies, but why does not everyone suffer from cancer? In fact, this is mainly due to the immune cells in our body, such as white blood cells , killer T cells , NK cells , etc. , these cells are the army that fights against cancer cells in our body. When cancer cells appear in the body, they will be engulfed by these immune cells. Therefore, even if there are cancer cells in our body, we will not suffer from cancer. .
But if our body’s immunity declines, or cancer cells proliferate in large quantities beyond the control of immune cells in our body, cancer tumors may appear, and we will suffer from cancer.
Now let’s talk about it again. “Pan-cancer” PD-1 inhibitors are on the market. What is the treatment principle?
“Pan-cancer” PD-1 inhibitors are on the market, mainly for cancers that cannot be treated by ordinary medical methods. For patients with advanced , many people will wonder, who is this drug that is so powerful, specifically for late-stage cancer?
As we said above, cancer cells are formed in our bodies, but not everyone gets cancer because of the The immune cells chase and kill all the cancer cells. How do the cancer cells in patients with cancer escape the pursuit of immune cells? In fact, this is because the gene mutation in cancer cells produces a PD -L1, this substance can inhibit T cells that target cancer cells in the body, avoid being hunted by T cells and start to proliferate in large numbers to form tumors.
And PD-1, also known as programmed death receptor 1, can bind to PD-L1 in cancer cells, allowing T cells in the body to start hunting cancer cells again , thus helping the body fight cancer. This is how PD-1 inhibitor drugs mainly treat cancer. Generally, these drugs are permanently effective. If the drug effect continues to take effect in the body after the patient is cured by the drug, it can restore the prognosis of the cancer and prevent recurrence. Can produce the effect .
Currently, as the first domestic pan-cancer "PD-1 inhibitor" H drug, the price is only Single retail price: 5588 yuan/100mg, As a domestic drug, the price is generally one-tenth of the price of imported drugs. This is undoubtedly good news for the majority of cancer patients.
It would be great to have better and more affordable cheap anti-cancer drugs, but in daily life we should also pay attention to cancer prevention and some bad things in life. Habits can make cancer cells become more aggressive. What should you do if you want to reduce the risk of cancer?
. Avoid known carcinogens
Many people feel that they are far away from cancer, but in fact there are known carcinogens around us. There are quite a lot of substances, including cigarettes, alcohol, betel nuts, , which are all recognized as carcinogens in the world. Aflatoxin, , mainly exists in grains and may cause acute poisoning, severe liver damage, as well. First-level carcinogens can easily induce liver cancer . If you renovate your home, the formaldehyde contained in some template latex paints is also a carcinogen and may nitrosamines and other substances in pickled foods. Nitrite all have cancer risks.
2. Enhance physical fitness
The immune cells in our body are very powerful and can be said to be the natural nemesis of cancer cells. If we have good physical fitness and strong immunity, the risk of cancer will be higher. Low . Therefore, in our daily life, we can eat lightly and exercise more to enhance our physical fitness, which can help our body's immune cells better fight against cancer cells produced in the body, and the risk of cancer can naturally be reduced.
3. Don't. Avoid medical treatment
Before being diagnosed with cancer, many cancer patients often think that they just have a minor problem and can just take a rest. It is precisely because of this attitude that many cancers are in the late stage when they are discovered. Those who smoke and drink all year round, have a family history, have chronic inflammation that cannot be cured, or have long-term exposure to carcinogens such as industrial chemical dyes are all at high risk of cancer. This group of people should undergo targeted early-stage cancer screening regularly. Early detection and early treatment can reduce the risk of cancer.
Although cancer is scary, with the development of science and technology, the treatment methods against cancer have gradually become more advanced. In many cases, cancer can also be prevented. In life, we maintain good living habits, do not delay timely treatment when we are sick, and see a doctor when we are not feeling well. For us, we can better detect cancer and treat it in time.
Reference:
"The Action Mechanism and Structural Characteristics of PD-1/PD-L1" Medical Circle 2021-07-30
"Does having cancer cells mean you have cancer?" Yangcheng Evening News 2015-05-11
"How far away is cancer from us?" Normal people produce 400 cancer cells every day》 Daqing.com 2018-11-27
