venlafaxine is a serotonin and norepinephrine reuptake inhibitor . By selectively blocking the reuptake of serotonin transporter and norepinephrine transporter, the content of serotonin and norepinephrine in the central nervous system is increased, and the effects of serotonin and norepinephrine in the central nervous system are enhanced, and the effects of serotonin and norepinephrine in clinical practice are mainly used to treat depression. It has a significant effect on anxiety symptoms in patients with depression, especially suitable for patients with depression with anxiety. In addition, venlafaxine also has a strong anti-anxiety effect and can be used clinically to treat generalized anxiety disorder , with a certain effect and a high cure rate.
agomelatine is a novel antidepressant, belonging to melatonin receptor and serotonin 2c receptor antagonist, which can adjust the circadian rhythm and specifically increase the release of norepinephrine and dopamine in the prefrontal cortex, exert antidepressant effect, and has no effect on extracellular serotonin levels. It is suitable for adult depression.
trazodone is a specific antidepressant of serotonin reuptake inhibitor. It mainly blocks serotonin reuptake and increases the serotonin content in the synaptic cleft to produce antidepressant and anti-anxiety effects. It also has a sedative and hypnotic effect. It is mainly used in clinical practice to treat depression, especially for patients with depression accompanied by anxiety. For patients with depression or anxiety-related insomnia, trazodone can improve sleep quality, reduce the number of sleep latency and night awakenings, thereby effectively alleviating depression and anxiety.
Doxetine is a drug for serotonin and norepinephrine reuptake inhibitor. By inhibiting serotonin and norepinephrine reuptake in central neurons, it enhances serotonin and norepinephrine reuptake, and exerts antidepressant and central analgesic effects. It is mainly suitable for depression and generalized anxiety disorders, and can also be used to treat peripheral neuropathic pain, fibromyalgia and chronic skeletal muscle pain in diabetes.
escitalopram is an S-isomer of citalopram . It is a highly selective 5-hydroxytryptamine (5-HT) reuptake inhibitor. Its effect and mechanism are similar to fluoxetine . By selectively inhibiting 5-HT reuptake, it increases the concentration of 5-HT concentration in the synaptic cleft, thereby enhancing the central 5-HT neuron function and exerting an antidepressant effect. Long-term use has downregulated the 5-HTh2 receptor function. Escitalopram has little effect on reuptake of norepinephrine and dopamine. There is almost no affinity for alpha receptors, beta receptors, M receptors and H receptors.
In clinical practice, escitalopram can be used for depression; panic disorder with or without square terror. Other indications approved by the FDA: depression in children and adolescents aged 12 to 17; generalized anxiety disorder in adults.
flupipexoxanthium melitricin is a compound antidepressant, where flupipexoxanthium is an antipsychotic drug that plays an antipsychotic effect by blocking the dopamine D2 receptor. Small doses have anti-anxiety and anti-depressant effects. Melitriacin is an antidepressant. It mainly enhances the functions of the central serotonergic nerve and norepinephrine by inhibiting the reuptake of serotonergic nerves by the presynaptic membrane, thereby exerting an antidepressant effect. It is similar to the pharmacological effect of amitriptyline and has a weaker sedation effect. The compound preparation of the two drugs has antidepressant, anti-anxiety and excitatory properties, and is suitable for mild and moderate depression and anxiety disorders, such as neurasthenia, psychogenic depression, depressive neurosis , occult depression, psychosocial diseases with anxiety and emotional indifference, menopause depression, anxiety and depression in alcohol and drug addicts.
paroxetine is a phenylpiperidine derivative. It is a powerful and highly selective serotonin reuptake inhibitor. It can selectively inhibit serotonin transporter, block the reuptake of serotonin by the presynaptic membrane, prolong and increase the effect of serotonin, and thus produce an antidepressant effect. Only weakly inhibited the reuptake of norepinephrine and dopamine, and had no significant effect on other transmitters. There is no inhibitory effect on monoamine oxidase .It is suitable for the treatment of depression, especially for patients with depression accompanied by anxiety. It has a faster effect than tricyclic antidepressant , such as , and has a better long-term efficacy than matzine. It can also be used for the treatment of panic disorder, social phobia and obsessive-compulsive disorder.
sertraline is a powerful serotonin reuptake inhibitor, which can selectively inhibit serotonin transporter, block the reuptake of serotonin by the presynaptic membrane of central neurons, prolong and increase the effect of serotonin, thereby producing an antidepressant effect. It has only a slight effect on norepinephrine and dopamine. It is suitable for depression, including depression accompanied by anxiety, with or without a history of mania. Continuing to take it after satisfactory efficacy can effectively prevent the recurrence and recurrence of depression. It is also used to treat obsessive-compulsive disorder . After satisfactory efficacy, continuing to take can effectively prevent the recurrence of the initial symptoms of obsessive-compulsive disorder.
doxepin is a tricyclic antidepressant. It mainly enhances the functions of the central serotonergic nerve and norepinephrine by inhibiting the reuptake of serotonergic nerves and norepinephrine by the presynaptic membrane, thereby exerting an antidepressant effect, which can significantly improve the mood of depressed patients. In addition, doxepin can antagonize histamine H1 receptor and M choline receptor, which has anti-anxiety, sedation, muscle relaxation and anticholinergic effects. Its anti-anxiety effect usually occurs within a few days, and its anti-depressive effect usually occurs after 2 weeks. It is mainly suitable for depression and anxiety.
