Generally, the temperature of the child is between 37.5 and 38.0℃ (the axillary temperature shall prevail). When the mental state is good, you may not choose to use fever-reducing drugs for the time being. Parents only need to observe more, and can improve the comfort of children

Generally, the temperature of children is between 37.5 and 38.0℃ (the axillary temperature shall prevail). When the mental state is good, you may not choose to use antipyretic drugs for the time being. Parents only need to observe more, and can improve the comfort of children with fever by replenishing moisture in time, reducing indoor temperature, reducing clothing covers and quilts, and helping the skin dissipate heat.

Of course, what we are going to talk about today is that the age is older than 2 months, the body temperature measured underarms exceeds 38.2℃. Children with fever who are uncomfortable and depressed due to fever should be given antipyretics. There are two types of pediatric antipyretic drugs recommended by the World Health Organization and the Chinese pediatric guide. One is Acetaminophen (acetaminophen, such as Tylenolin), and the other is Ibuprofen (ibuprofen, such as Merrill Lynch), which is common as follows:

people with severe liver and renal insufficiency, and those who are allergic to acetaminophen or other ingredients of the preparation are prohibited.

. Long-term use of barbiturates (such as phenobarbital) or antispasmodic drugs (such as belladona ) can cause liver damage.

. If used concurrently with other drugs, drug interaction may occur. Please consult your doctor or pharmacist for details.

. Taking it together with other antipyretic, analgesic, and anti-inflammatory drugs can increase gastrointestinal adverse reactions and may cause gastric ulcer .

. Taken together with digoxin, methotrexate , oral hypoglycemic drugs can increase the blood concentration of this drug and should not be used together.

. The sodium discharge and antihypertensive effect of the latter is weakened when used with furosemide (furananilic acid); when used with antihypertensive drugs, it can also reduce the antihypertensive effect.

. If used concurrently with other drugs, drug interaction may occur. Please consult your doctor or pharmacist for details.

Drug name	Acetaminophen Suspension Drops Acetaminophen Suspension Drops l13	ibuprofen suspension
Effect category	Hydrogenic analgesics and over-the-counter medicines
Pharmacologic action	can inhibit prostaglandin synthesis and have antipyretic and analgesic effects.	can inhibit prostaglandin synthesis, has antipyretic and analgesic effects and anti-inflammatory and effects
Ingredients		Main ingredient 100 per milliliter of acetaminophen mg and its remaining auxiliary materials	per milliliter mainly consists of 20 mg of profen and its remaining auxiliary materials
indications		for fever caused by common cold or influenza . It is also used to relieve mild to moderate pain in children, such as headache, joint pain, migraine , toothache, muscle pain, neuralgia .
contraindications
is prohibited for allergic to other non-steroidal anti-inflammatory drugs; asthma patients with allergic to aspirin are prohibited.
Drug interaction
. Taken together with chloramphenicol can enhance the toxicity of chloramphenicol.
. Taking anticoagulants such as heparin , double coumarin can lead to prolongation of prothrombin time and increase bleeding tendency.

1

oral dosage

oral dosage

Ageminophen suspension: Children under 12 years old use droppers, and the dosage is shown in the table below:

dosage (ml)

-1.5

-3

0-15

-1.5

-1.5

-1.5

reuse of the medicine once, no more than 4 times in 24 hours.

-6

6-21

.5-2

html ml12

0-12

-3.5

Age (years)	weight (kg)
-9		2-27
-9		2-27	-3
	8-32

Note: Please shake well before use, and clean the dropper before and after use; children under 1 year old should take the medicine under the guidance of a doctor.

ibuprofen suspension: 12 children under the age of 312 use a measuring cup to measure the dosage, see the table below:

dollar (ml)

dollar (ml) l4

-3

0-15

-6

6-21

0-12

0

0

Age (years)	body weight (kg)
Number of times a day
If the pain or fever continues, the medication can be repeated once every 4-6 hours, and no more than 4 times in 24 hours.
-9		2-27		html l0
	8-32

Note: Please shake well before use, and clean measuring cup before and after use; children under 1 year old should take medication under the guidance of a doctor.

Hometimes after taking the medicine are generally in 0-60 minutes , and the temperature drop time is in -2 hours . The peak time is -4 hours . The continuous action time of acetaminophen suspension (Tylenolin) was -6 hours , while the continuous action time of ibuprofen suspension (Merry Lynch) was -8 hours .

2

Adverse reactions

Drug		acetaminophen suspension (Tylenolin)	ibuprofen suspension (Merry Lynch)
Adverse reactions	Adverse reactions	Routine doses cause less adverse reactions, occasionally rash, urticaria, drug heat and granulocyte reduction; however, long-term large-scale medication will lead to abnormal liver and kidney function, and even acute liver failure. In addition, acetaminophen may cause rare and severe skin reactions, including the deadly Stevens-Johnson syndrome, toxic epidermal necrolysis, etc.	is generally mild gastrointestinal discomfort, occasionally with rash, tinnitus , headache, etc., which can cause gastrointestinal bleeding in severe cases. There are also reports of acute kidney injury in .
Treatment measures	When serious adverse reactions occur, the drug should be stopped and symptomatic treatment should be given; acute poisoning should be given acetylcysteine ​​ to rescue, and the corresponding treatment should be given according to the condition. If serious adverse reactions occur, the drug should be stopped. If gastrointestinal bleeding or ulcer occurs, the proton pump inhibitor should be given; if acute renal injury occurs, different treatments should be taken according to the severity of the renal injury.

3

Reasonable clinical application and precautions

. Combination or alternation of acetaminophen and ibuprofen are not recommended;

. It is not recommended to relieve fever and analgesics. The medicine is used in combination with a compound cold medicine containing antipyretic analgesics;

. Children with asthma should use antipyretic drugs after a comprehensive assessment of their condition;

. Acetaminophen is prohibited when liver function is abnormal and fever is accompanied by fever, and ibuprofen can be used if necessary;

. Ibuprofen is prohibited when children with moderate renal function injury or above or renal insufficiency are accompanied by fever, and acetaminophen can be used if necessary;

. ibuprofen is not used for antipyretic analgesic treatment for children with cardiac insufficiency and heart failure . Acetaminophen can be used if necessary;

. When children with hemorrhagic diseases have fever, they need to weigh the pros and cons. If necessary, they can choose drugs such as acetaminophen that have less impact on coagulation function;

. KD (Kawasaki disease) for acute phase use of high-dose aspirin anti-inflammatory treatment without using other antipyretic analgesics;

9. Acetaminophen It is contraindicated for children with G-6-PD (grape-6-phosphate dehydrogenase) deficiency;

0. It is not recommended to use antipyretic drugs after vaccination;

1. It is not recommended to use antipyretic analgesics to treat General anesthesia malignant high fever , central fever, and ectodermal dysplasia;

2. The use of antipyretic analgesics in children with malignant tumors needs to weigh the pros and cons.

4

Dosage form

The two medicines introduced above are suspensions and oral preparations. Another type is suppository . Rectal administration is a non-gastrointestinal absorption method. In the case of vomiting, difficulty in oral administration or inability to take oral administration to treat antipyretic treatment, suppository can be given for treatment.

After reading this, I want to tell you that the main purpose of reducing fever is to relieve discomfort caused by fever, not simply to restore normal body temperature. In special circumstances, the organs should be protected and the function should be actively cooled down to find and treat the causes of fever. Thank you for reading!

Content source: Medicine Circle Network WeChat public account

Organized and edited by: Journal of Integrated Traditional Chinese and Western Medicine

Correspondent: Qin Shasha Sun Lei Wang Jingjing Dong Wei