: Taking statins for a long time is easily criticized by patients, that is, side effects such as liver function abnormalities, muscle damage, and increased blood sugar may occur. Among them, liver function abnormalities are one of the most common side effects.
First of all, what everyone needs to understand is, what manifestations can be defined as liver function damage caused by taking statins?
There are usually two clinical standards: one is that long-term use of statin has caused the quasi-transferase and alanine aminotransferase to exceed three times the upper limit of the normal value. At this time, you need to stop taking statins immediately, and then consult a doctor to switch to other types of lipid-lowering drugs.
The second standard is that the indicators such as glutinous aminotransferase and alanine aminotransferase have increased, and the bilirubin has also increased. Among them, direct increase in bilirubin indicates that liver function may be damaged due to taking statins. At this time, you also need to consult a doctor whether you need to reduce the dosage of statins, or convert them into other types of lipid-lowering drugs.
Of course, not everyone will have side effects when taking statins, and there are mainly five major categories of people who are prone to liver dysfunction: one is people with fatty liver; two is people who drink for a long time; three is people who do not pay attention to the interaction with drugs and food when taking statins; four is people who have chronic liver disease; five is people who are thin and older than 70 years old. If these five groups want to take statins, they must be taken under the guidance of professional doctors.
I believe that one of the most concerned questions is what to do if you take statins to cause liver function abnormalities and how to adjust lipid-lowering drugs?
has three main solutions: First, if taking statins causes the stamina transaminase and alanine transaminase to exceed three times the upper limit of the normal value, or there is a significant increase in bilirubin, you need to stop using statins immediately.
After the liver function returns to normal, you can use another statin, such as atorvastatin, which can be converted into rosuvastatin, or a small dose of statin combined with ezemeb, or an PCSK9 inhibitor is injected.
These solutions can not only effectively reduce blood lipids , prevent the occurrence of cardiovascular and cerebrovascular diseases such as cerebral infarction , myocardial infarction, etc., but also reduce the occurrence of side effects such as liver function abnormalities, blood sugar increase, and muscle damage to a certain extent.
The second is to actively treat liver diseases such as fatty liver and chronic hepatitis, and at the same time quit drinking as soon as possible. Also, when taking statins, pay attention to the interaction between drugs and food, which can effectively prevent liver damage.
The third is to review regularly. Although American guidelines believe that regular reviews do not require any statin after taking it. However, our national clinical guidelines recommend that you review regularly after the first month of taking statins or 2 to 3 months.
's main review items include four indicators: liver and kidney function, blood sugar, creatine kinase, and blood lipids. This is mainly to avoid the possible side effects of taking statins. After the condition stabilizes, you can have a review every six months.
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