is for medical professional reading only for reference
Evidence-based medicine, rational use of medicine
amiodarone is a multifunctional class III antiarrhythmic drug that extends the action potential time course. It has multi-channel and multi-site effects and is considered to be one of the most effective and widely used antiarrhythmic drugs in clinical practice.
amiodarone is widely used in clinical practice, but the incidence of adverse reactions is high and the harm is serious. Jiexiao medicine, remind you to pay attention to its safety when applying it.
What are the clinical applications of [1-6]?
1. Atrial arrhythmia (atrial flutter, atrial fibrillation rotation; maintenance of sinus rhythm after rotation).
2. Nodular arrhythmia.
III. Ventricular arrhythmia (prevention of life-threatening prevention of ventricular systolic and ventricular tachycardia and ventricular tachycardia or ventricular fibrillation).
is suitable for ventricular tachycardia that is invalid for lidocaine .
oral administration is suitable for the prevention of life-threatening paroxysmal ventricular tachycardia and ventricular fibrillation. It can also be used for the prevention of life-threatening paroxysmal supraventricular tachycardia , paroxysmal atrial flutter, atrial fibrillation, including maintenance treatment after combinatorial pre-excitation syndrome and continuous atrial fibrillation and atrial flutter electroreversion. It can be used to control the room rate during continuous atrial fibrillation and atrial flutter.
is generally not suitable for the treatment of atrial and ventricular premature beats, except for clear indications.
4. arrhythmia with W-P-W syndrome .
5. CPR related to cardiopulmonary resuscitation of ventricular fibrillation ineffective in vitro electrodefibrillation.
FDA black box warns amiodarone lung, liver and cardiotoxicity!
amiodarone is only suitable for the treatment of patients with life-threatening arrhythmias, as its use is accompanied by a large amount of toxicity.
amiodarone can cause pulmonary toxicity (hypersensitivity pneumonia or interstitial/alveolar pneumonia), resulting in up to 17% of clinically significant diseases in some patients. Pulmonary toxicity is fatal in about 10% of cases. When starting amiodarone treatment, baseline chest X-rays and lung function tests , including diffusion ability. Recheck the medical history, physical examination, and chest X-ray every 3 months.
amiodarone can cause hepatotoxicity, which can be fatal. Baseline and periodic hepatic aminotransferase levels were obtained and if the baseline elevation exceeded three or twice the normal value, the dose was stopped or reduced. If the patient has signs or symptoms of clinical liver injury , please stop using amiodarone.
amiodarone can aggravate arrhythmia. Amiodarone is used in clinical settings where continuous ECG and cardioresuscitation are available [7].
Special groups should pay attention to the medication [1-6]
Children: amiodarone for injection contains benzyl alcohol , there are reports of fatal asthma syndrome in newborns (babies less than 1 month old) after intravenous administration. Symptoms include rapid breathing asthma, hypotension , arrhythmia and cardiovascular failure.
Elderly: Generally speaking, the dose given to the elderly should be carefully selected, usually starting with a low dose in the dosage range, taking into account the faster frequency of liver, renal or cardiovascular hypofunction and the higher likelihood of accompanying disease and other drug treatments.
More popular medicines in the department, where to learn?
If you have just entered the department, where can you read the commonly used drugs in the department? What conditions dosage adjustments need? Should I double the first time I use it? solvent is salt or sugar
As a veteran in the department, what are the differences between injections and tablets? What are the usages abroad that can be learned from? How to deal with overdoses? When facing new students who have entered the subject, how can I gracefully throw a link to let Xiaobai learn medicine knowledge?
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Reference materials:
[1]Drug information: Amiodarone hydrochloride tablets, Shandong Xinyi Pharmaceutical Co., Ltd., National Drug Profile H3702145.
[2] Drug information: Amiodarone hydrochloride tablets, Sanofi (Hangzhou) Pharmaceutical Co., Ltd., National Drug Approval H19993254; 2020/12/30.
[3] Drug information: Amiodarone hydrochloride injection, Sanofi Winthrop Industrie, imported drug registration number H20181048; 2018/07/18.
[4] Drug information: amiodarone hydrochloride for injection, Zhejiang Jianfeng Pharmaceutical Co., Ltd., National Drug Profile H20020021; 2009/04/21.
[5] Drug information: Amiodarone hydrochloride dispersed tablets, Guangdong Shixin Pharmaceutical Co., Ltd., National Drug Approval H20090151.
[6] Drug information: amiodarone hydrochloride capsule, Harbin Pharmaceutical Group Pharmaceutical Factory 6, National Drug Approval H23021766.
[7]Product Information:PACERONE-amiodarone hydrochloride tablet,Upsher-Smith Laboratories, Inc.,Updated November 8,2018.
