Author: Hubei Provincial Third People's Hospital Zhong Ting and Fang Shasha
Nowadays obesity has become a global public health crisis, seriously endangering people's physical health. How to effectively lose weight has become a hot topic in today's society. After experiencing various and strange ways to lose weight, Fat King is still "still moving". Once upon a time, did you also want to seek some shortcuts? Little do you know that the wrong weight loss method may make health leave you.
"Qumei" has cooled down
Do you still remember the popular "Qumei"? It was cool due to the addition of banned ingredients (sibutramine). Sibutramine is a central nervous system inhibitor. While inhibiting appetite, it may cause serious side effects such as hypertension and , accelerated heart rate and abnormal liver function. In severe cases, it can cause nerve disorders or even death. "Qumei" was also ordered to delist by the State Food and Drug Administration of my country.
So are there any relatively safe and effective weight loss pills approved by the state? Let’s learn about the only approved weight loss pill in our country!
Orlistat—the only approved weight loss drug in my country
Orlistat (Orlistat), developed by Swiss Hoffmann La Roche. It was first launched in New Zealand in 1998 and was launched in the United States the following year. It was launched in my country in 2001 and was officially approved as an over-the-counter drug for weight loss in 2007.
Orlistat weight loss principle
Orlistat is a gastrointestinal pancreatic lipase inhibitor, which can inhibit gastric lipase and pancreatic lipase, hinder fat decomposition, and prevent fat from being absorbed. In other words, orlistat can allow fat to "pass through the intestines" and be excreted directly from the body with the feces. In this way, you don’t have to worry that they will turn into fat and stick to you!
Orlistat prevents the oil in food from being absorbed by the human body in the digestive tract, so that the oil is directly excreted from the anus, achieving the purpose of reducing caloric intake. It does not have the ability to convert the existing fat on the body into oil and excrete it out of the body, but only prevents the human body from absorbing oil. Because of this characteristic, orlistat is sometimes called "oil pills".
Since orlistat has been approved in China, is it reliable to lose weight?
Orlistat usage tips
1, Although orlistat has been approved in many countries and is also a relatively safe weight loss pill, it does not mean that everyone can use it to lose weight.
2FDA-approved orlistat is suitable for two groups: one is obese people with body mass index (BMI) ≥30kg/m2; the other is patients with BMI ≥27kg/m2 and symptoms such as hypertension and diabetes .
3, In my country, orlistat is used for the treatment of obese or overweight patients (BMI ≥24kg/m2) in adults aged 18 and above.
4 and orlistat instruction manuals are recommended for taking three times a day and during the consumption of fat-containing dishes or within 1 hour after meals. If the person taking the medicine takes one less meal, or the meal does not contain fat, then you can take the medicine less.
Adverse reactions of orlistat cannot be ignored
Safety knowledge science popularization
1, common adverse reactions
Common oily stool, urgency of stool, increased gastrointestinal exhaust, increased fat diarrhea and bowel movements, and Female incontinence , etc. low-fat diet can reduce the occurrence of such adverse reactions.
2, acute gastrointestinal reactions
Abdominal pain, flatulence, watery stool, rectal discomfort, tooth/gum discomfort.
3, other adverse events
upper and lower respiratory tract infection , influenza , headache, monsoon disorder, fatigue, urinary tract infection .
4, rare adverse events
have been reported with rare elevated aminotransferase, increased alkaline phosphatase and severe hepatitis, and cases of liver failure have appeared, some of which require liver transplantation.
Notes
· Dosage increases, the effect does not increase
Overdose will not bring additional effects, but will increase side effects.
· Control diet
Orlistat can only inhibit the absorption of fat in the diet, but it has no effect on the absorption of carbohydrate (such as staple foods, desserts, beverages, etc.). Too much carbohydrate intake in will also turn into fat accumulation in the body.
· Supplement of vitamins
orlistat will affect the absorption of fat-soluble vitamin (vitamins A, D, E), etc., and a multivitamin is needed.
·The following people are not recommended to use:
. Children under the age of 18, pregnant women and breastfeeding women.
. It is contraindicated for patients with organic obesity, such as those with hypothyroidism.
. People who are allergic to any ingredient of this drug.
4. People with chronic malabsorption syndrome or cholestasis.
5. Organ transplants and patients taking cyclosporine.
6. Those who are not overweight.
Pharmacist reminds: Healthy weight loss and safety first
"Slim body, take it with a good idea". Fat friends, don’t be too hasty. Before using weight loss drugs, it is recommended to ask the doctor and pharmacist for advice. Choose a weight loss method that suits you and do not blindly follow the trend. Based on drug treatment, cooperate with diet control, strengthen exercise, develop good living habits, maintain a happy mood at any time, and achieve unexpected weight loss results!
Reviewer: Deputy Director of Pharmacist of Hubei Third People's Hospital Anwei
or above are original works of volunteers of the "Drug Safety Cooperation Alliance". If reprinted, please indicate the author and source!
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