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GE Medical United Cleveland Clinic has laid out an augmented reality 3D imaging interventional navigation company!
On June 27, 2022, Centerline Biomedical announced the completion of a US$33 million (approximately RMB 216 million) Series B financing led by the Cleveland Clinic.
It is worth noting that GE Healthcare , RIK Enterprises, JobsOhio, Jumpstart Ventures and G2 Group Ventures also participated in this round of financing.
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Centerline Biomedical, a research and development project spun off from the Cleveland Clinic, 's flagship product IOPS is a non-radiation 3D surgical navigation system for vascular interventional surgery.
Currently, interventional surgery navigation is inseparable from X-ray . This navigation method not only exposes the surgeons involved in the operation to high doses of radiation but also results in lower image quality. 2D images cannot fully reflect the true anatomical structure.
IOPS uses anatomical mapping algorithms and electromagnetic tracking technology to combine preoperative imaging and intraoperative correction positioning system data, without the need for standard X-ray imaging and contrast agent injection.
digital algorithm can present vascular structures and intraoperative images in 3D. Doctors wearing VR glasses can receive three-dimensional color visual navigation , which not only reduces the doctor's radiation exposure, but also greatly improves the accuracy and accuracy of navigation. Operation efficiency: Compared with traditional navigation methods, operation time is shortened by nearly half. The endovascular aortic repair (EVAR) application of
IOPS received FDA 510(k) approval in July 2019. The company is currently working to expand the application scope of the system. In May this year, the company announced that it had completed a structure Animal research on surgical navigation of sexual heart disease. The research equipment used for surgery is based on the current IOPS and uses 4D-GNC technology. generates cardiac augmented reality guidance with four-dimensional structural mapping.
combined with the recently popular metaverse concept, this is a definite step forward in the direction of metaverse medical imaging! What is particularly exciting is that this technology is not a floating concept, but a commercial product that has been in use for nearly three years.
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3D imaging technology received the largest financing in history
- 0% of interventional doctors have obvious posterior subcapsular lens changes, and this symptom is a precursor to cataracts.
- 5% of interventional surgeons' brain tumors occur on the left side of the head - the part of the body closest to the radiation source when doctors perform interventional surgeries.
- 0% of interventional doctors will have spinal problems after 21 years of practice due to long-term wearing of heavy radiation protection clothing .
- 3% of interventionalists have been absent from work due to orthopedic disease.
This set of numbers listed on the official website of Centerline Biomedical is exactly the problem that today's interventional doctors need to face. Long-term radiation exposure inevitably causes serious health damage to doctors.
In order to solve this problem, Centerline Biomedical's IOPS intraoperative positioning system abandons traditional X-ray guidance, using preoperative CT arteriography images combined with an intraoperative positioning calibration system placed on the patient's waist, through anatomical mapping algorithms and electromagnetic tracking technology , providing real-time three-dimensional color visual navigation during vascular interventional surgery.
3D color images can reflect the anatomical structure of blood vessels more intuitively than previous 2D gray images. With the help of VR glasses, the navigation effect is faster and more accurate, and the surgical efficiency has been significantly improved. The average operation time of only requires traditional 2D 53.4% of navigation.
The heartbreaking story behind the technology
The system was developed by the Cleveland Clinic's Heart and Vascular Institute, ranked #1 in the United States. There is also a sad story behind the birth of this system.
Vikash Goel, founder and chief technology officer of Centerline Biomedical, studied at Cornell University with Professor Don Greenberg, a leading expert in the field of computer graphics. Professor Greenberg introduced Vikash to his son, Dr. Roy Greenberg, a top expert in complex aortic repair at Cleveland Clinic.
Roy invited Vikash to cooperate with him, and the team formed by the two jointly developed IOPS technology for 10 years. But unfortunately, Roy passed away from cancer a few years ago. Many people believe that intraoperative radiation was the main cause of Roy's disease.
The unfortunate death of Dr. Roy has also become the motivation for Vikash to continue to work hard to reduce intraoperative radiation. In July 2019, the endovascular aortic repair (EVAR) application of IOPS received FDA 510(k) approval.
Heading towards 4D
Since then, Centerline Biomedical has continued to work hard to develop more applications for IOPS systems. currently has four R&D pipelines, namely: peripheral vascular disease (PAD), structural heart disease (various applications), neurovascular diseases and other vascular and non-vascular applications.
Recently, there have been new developments in the company's structural heart disease applications. In May of this year, Centerline Biomedical announced that it had completed the second in a series of structural heart navigation animal studies.
Physicians from Cleveland Clinic’s Heart, Vascular and Thoracic Institute, the nation’s #1 ranked institution, evaluated the feasibility of the company’s augmented reality image guidance technology to navigate structures in the beating heart.
What’s even more noteworthy is that the research 4D-GNC technology being trialled is built on the company’s flagship IOPS® product, with four-dimensional structural mapping and through-the-heart augmented reality guidance, meaning the company’s augmented reality navigation Technology has reached a new level.
The $33 million in funding Centerline received is the largest financing the company has received since it was spun off from the Cleveland Clinic in 2014. In addition to expanding the applications of its intraoperative positioning system (IOPS), Centerline said it will use the Series B funding to expand its clinical evidence base.
IOPS is currently being rolled out in select hospitals in the United States and is expected to expand to Europe and other major markets by 2023.
GE Medical’s participation in this round of financing is also particularly eye-catching. Arnaud Marie, General Manager of Global Interventions at GE Healthcare, said:
“The opportunity to invest in innovative technologies like Centerline Biomedical’s IOPS® solutions aligns with GE Healthcare’s mission to deliver more precise and efficient care. With minimally invasive treatments for complex interventions, As the number of surgeries increases, so does the need for advanced technologies to enable clinicians to make faster, more precise and more informed decisions to improve patient care We look forward to working with Centerline Biomedicine and clinicians, Explore the possibilities of this technology and how it can be used to complement our imaging and guidance systems. ”
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GE Medical Plus Interventional Imaging Field
Interventional radiology is a field of diagnostic imaging and clinical diagnostics guided by medical imaging equipment. Basic, combined with the principles of clinical therapy, the use of catheters, guide wires and other equipment to diagnose and treat various diseases. After came out in the 1970s, after more than 50 years of development, it has become the third largest clinical discipline after internal medicine and surgery.
Among them, DSA equipment has always been the top priority in the interventional catheterization laboratory. From the early image intensifier, to the first flat-panel DSA launched by GE Healthcare in the industry in 2000, to the new generation of hybrid operating room Discovery IGS 7OR, the vascular machine Hardware technology, image processing, etc. have undergone earth-shaking changes.
Interventional imaging has always been an area of focus for GE Healthcare.
One-stop multi-device integration
In 2020, GE Healthcare announced the launch of one-stop multi-device integration INTERACT Angio-CT Suite. This is currently the industry's leading one-stop solution that can simultaneously integrate DSA, CT and ultrasound imaging equipment.
After interventional surgery, a CT scan is usually required to evaluate the condition. However, under the traditional model, patients cannot have a CT scan immediately after the surgery and can only do it at an elective time. If the surgical effect is not good, a second surgery may be required, which increases the risk of treatment and puts additional financial pressure on the patient.
For diseases where the use of ultrasound equipment for imaging examination and evaluation is more advantageous, it is often necessary to rely on the equipment of the ultrasound department and the assistance of ultrasound doctors, which requires patient transportation. The process is complicated, which also leads to longer operation time and low utilization efficiency of the catheterization laboratory.
INTERACT Angio-CT Suite integrates GE's advantageous CT, DSA, and ultrasound equipment in one stop and links them in real time to give full play to the respective advantages of the three imaging equipment and optimize clinical benefits.
GE's unique "ASSIST multi-modal fusion disease navigation" technology ensures that the advantages of different images can be fully exerted under the collaboration of multiple devices. Through the new post-processing workstation system, the rapid synchronization of different image guidance data is achieved to ensure that different images Multi-modal fusion realizes the three major characteristics of "multi-source, multi-volume and multi-morphology". For interventional treatment of tumors and large blood vessels, can save up to 90% of contrast agent consumption, reduce radiation and improve safe treatment, while significantly Shorten operation time.
GE Healthcare joins forces with Johnson & Johnson to build a green cath lab
Just like Centerline, which GE Healthcare has just invested in, reducing the radiation exposure of interventional doctors has always been a focus of GE Healthcare.
The third-party data disclosed by
shows that there are currently about 100,000 atrial fibrillation surgeries in my country every year, and this number is expected to reach 1 million in 2035. At present, when performing atrial fibrillation surgery with the support of catheterization laboratories and vascular machines, the radiation exposure is about 2 to 3 hours per unit. Doctors need to carry heavy lead garments when performing electrophysiological interventional surgeries. According to statistics, the average age of interventional doctors in China is 10 years younger than that in the United States, but the proportion of back pain among Chinese doctors is much higher.
Last year, the overall green catheterization laboratory solution jointly created by GE Healthcare and Johnson & Johnson Healthcare was officially released with the witness and support of industry associations and experts at the 19th Atrial Fibrillation International Forum. This solution provides a zero-ray solution for atrial fibrillation surgery through ultrasound equipment, heart cavity intracardiac ultrasound catheter and three-dimensional mapping equipment, and guides atrial fibrillation surgery more safely and accurately.
As the number of patients with atrial fibrillation increases, atrial fibrillation centers are being rapidly established, and more and more cath labs are being built due to demand on the treatment side. This time, GE Healthcare China and Johnson & Johnson Medical jointly created an overall green cath lab solution, using ultrasound equipment, intracardiac ultrasound catheters and three-dimensional mapping equipment to provide a zero-ray green solution for atrial fibrillation surgery, providing safer and more accurate guidance for the room. tremor surgery, greatly improve the efficiency of surgery, and protect the safety of doctors and patients.
The green cath lab will play a very important role. The green cath lab can make atrial fibrillation surgery safer. There is no radiation, no need to wear lead clothing, precise guidance, and doubled safety; safety is achieved to the extreme and efficiency is improved; after the efficiency is improved, doctors will Have more time to devote to scientific research and improve academics.
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With the rapid technological advancement, the field of intervention in image navigation has also undergone unprecedented changes.Combined with the currently popular metaverse concept, augmented reality images can achieve intraoperative navigation accurately and quickly.
On the other hand, the health problems of doctors who are exposed to radiation for a long time have gradually received attention. With the support of new technologies, various innovative green solutions are emerging one after another. Device Home will continue to pay attention to what other exciting inventions there will be in this field in the future.
