incident review: Mr. Luo was diagnosed with advanced lung cancer in August 2020 and has lost the opportunity for surgical treatment. The local hospital recommended systemic chemotherapy. After the fifth round of chemotherapy, the side effects were very obvious. Mr. Luo vomited every day and could not eat. He was very uncomfortable. He also seemed to be losing weight day by day. Mr. Luo did not want to go back to the hospital. Went for chemotherapy. Later, a friend introduced a minimally invasive interventional treatment method - radioactive iodine 125 seed implantation. The treatment effect is very good and there are no obvious side effects. After treatment, a 4-month review showed that Mr. Luo's lesions had shrunk significantly. Now he eats and sleeps normally, and he often goes fishing with his friends.
What are iodine-125 particles? Why it can kill cancer cells
The conventional treatments for cancer are surgery, radiotherapy and chemotherapy. Radioactive seed implantation therapy is actually a branch of radiotherapy. Traditional radiotherapy is external radiotherapy, which uses radiation to kill cancer cells. The implantation of radioactive particles uses the principle of radiotherapy to implant tiny radioactive particles into the patient's tumor lesions.
Iodine 125 particles are used to accurately locate the tumor site through CT or B ultrasound equipment and lock the position of the tumor. Minimally invasive puncture is performed under image guidance, and iodine particles with a diameter of less than 1 mm and a length of less than 5 mm are implanted into the tumor tissue. According to the size and location of the tumor, a sufficient number of iodine particles are carefully placed to "detonate" the tumor cells from the inside out.
The therapeutic advantages of iodine-125 seed implantation
Compared with traditional surgery and radiotherapy and chemotherapy, the treatment method of radioactive seed implantation does not have to be as drastic as surgery, and it will not cause as much damage to the patient's body as traditional radiotherapy and chemotherapy. Serious impact.
Moreover, traditional external radiotherapy is intermittent, giving cancer cells a chance to linger, while the implantation of radioactive seeds can provide continuous treatment. Iodine 125 particles only kill tumors and cause very little damage to surrounding normal tissues. It has many advantages such as less trauma, fewer side effects, direct curative effect, and repeatability, which greatly extends the patient's survival time. What is the clinical treatment effect of
iodine 125 particles? The clinical application of
has confirmed the positive effect on prostate cancer , pancreatic cancer , liver cancer , breast cancer , lung cancer, etc., which is manifested in tumor tissue shrinkage, reduced metastasis and recurrence, and improved survival rate. Especially in prostate cancer, which has been used for nearly 30 years, the local tumor control rate in 2 to 5 years can reach 83 to 100%, which is slightly higher than that of radiotherapy.
In recent years, iodine 125 seed implantation therapy has been gradually used in the treatment of bone metastasis cancer. Its analgesic efficiency reaches more than 92%, and it helps to reduce the size of bone metastasis cancer lesions. It is mainly used in stubborn cases where zoledronic acid is ineffective. bone metastasis lesions.
Indications of iodine-125 particles
(1) Patients with clinically diagnosed malignant solid tumors.
(2) Solid lesions less than 6cm in diameter. For patients with
(3) locally advanced stage, seed implantation needs to be combined with external radiation and other comprehensive treatment measures.
(4) For those whose local progression is difficult to control with local treatment, or who have distantly metastasized advanced tumors but severe symptoms caused by local lesions, seed implantation may also be used to achieve the purpose of palliative treatment .
(5) Remains visible to the naked eye or under the microscope during the operation.
(6) Late-stage tumor patients who have failed surgery + radiotherapy + chemotherapy;
Cancers that are currently commonly used for particle implantation in China include: early prostate cancer, lung cancer, head and neck tumors , pancreatic cancer, liver cancer, brain tumors, kidney tumors , adrenal tumors and soft tissue tumors . Iodine 125 seed implantation therapy is currently recognized as an effective treatment for early localized prostate cancer. Iodine 125 seed implantation has the advantages of high local control rate, small trauma, one treatment, few side effects, relatively safe, continuous radiotherapy, little damage to surrounding tissues, and easy radiation protection. Currently, no harm to medical staff or patients’ families has been found. Reports of adverse effects.
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