10 years ago, the doctor told her that no chemotherapy regimen could make her heal and that her survival period was less than one year. After receiving a brand new immunotherapy, all her lesions disappeared, and so far, each follow-up expert told her that there is still no cancer in her body, a result she never thought she would hear after diagnosing advanced cancer, and she has returned to normal life.
confirmed: Advanced cancer without any chemotherapy can be "cured"
Aricca Wallace's abdominal cramps and irregular bleeding lasted for more than 3 years. She has always believed that it is a side effect of the IUD, and the cervical smear test is normal every year. In the summer of 2011, until the moment she went to the hospital to remove the IUD, a nightmare quietly came - stage III cervical cancer.
As a strong mother, Aricca decides to fight cancer to the end. However, after multiple rounds of radical chemotherapy and radiotherapy, the condition did not improve after surgery. The examination results showed that the cancer had spread to the chest, which meant that her cancer had reached its advanced stage. The doctor said that there is no chemotherapy regimen for that can "cure" her , and can only control her condition and told her that she may not live for a year.
The first cervical cancer patient who received a novel immunotherapy in the United States has completely disappeared!
In early 2012, just as Aricca's life was becoming increasingly weak due to chemotherapy, the attending doctor told her that the National Institutes of Health Clinical Center was conducting a clinical trial of immunotherapy, but it has not been tested in patients with cervical cancer. The hope is slim, but it may work.
Aricca decided to give it a try, there would be no worse result than facing death, this is her last hope.
In May 2012, Aricca met Dr. Hinrichs of the National Cancer Institute and formally received a brand new immunotherapy after a series of evaluations.
Immunotherapy is to use the patient's immune system to attack tumors to solve a medical problem that is still unsolvable: how to kill cancer after it spreads.
The TILs therapy developed by Professor Rosenberg, the team of the National Cancer Institute, overcomes this problem!
Rosenberg published a data from 93 patients with melanoma treated with TIL, showing that 52 cases responded to the therapy. Twenty of 52 people saw their cancer disappear, although one of them relapsed after 19 months and the rest did not have cancer for five to nine years.
Dr. Christian Hinrichs, Professor Rosenberg's team, used this experimental new TILs therapy to treat cervical cancer, and Aricca was fortunate to become the first person to "eat crabs" .
First, the doctor removed a large lymph node in her chest and isolated some immune cells that could destroy the tumor . ( Those combat cells, called tumor-infiltrating lymphocytes, namely TIL, were injected into the patient's body after amplification of hundreds of millions of levels in the laboratory.)
8 months, TILs cells were cultured. They are in an IV bag and look like condensed milk. In fact, there are more than 100 billion in and immune cells that can accurately identify and kill tumor cells! These precious immune cells entered Aricca's body through infusion and began to "chase" cancer cells.
After experiencing the most severe fever in life, TILs cells take effect. The first scan after
1 months later, the tumor had shrunk by more than 50%, and some of it was completely invisible. After
4 months later, the doctor excitedly told her as he looked at the clear scan results, " To be honest, this is a miracle, no tumors were found! " This means that all Aricca's tumors disappeared.
22 months later, there are still no signs of cancer. Aricca has returned to normal life. She and her husband participated in the football game of their sons and watched them grow up healthy and happy.
TILs therapy may become a new hope for conquering cancer and is expected to be launched!
The story is far from over.
In March 2018, Aricca and another cervical cancer patient who had completely relieved after receiving TILs therapy, are also anti-cancer sisters who have accompanied each other through the most difficult time in their lives. They celebrated each other's victory over cancer for five years. The doctor announced that they have been clinically cured by !
In 2019, the second phase of the trial they participated in was officially released. The overall response rate (ORR) of TIL treatment in patients with advanced cervical cancer was as high as 44% .
At present, TILs therapy is expected to be submitted for marketing application in 2022. Once approved by the FDA, it will be the first cellular immunotherapy for solid tumor , which will bring huge survival benefits to cancer patients. The Department of Medicine of Global Oncology Doctors Network has written a large number of popular science articles. At the same time, TILs therapy has achieved outstanding clinical data in solid tumors such as lung cancer, breast cancer, , melanoma, sarcoma, and sarcoma.
The good news is that the TILs therapy developed in China has been approved to officially launch human clinical trials to recruit patients. Patients who want to know more can consult the Medical Department of the Global Cancer Doctor Network. What exactly is the TILs therapy that can completely relieve advanced cancer? TIL, the full name is Tumor Infiltrating Lymphocytes (Tumor Infiltrating Lymphocytes) . These cells are very precious, but they exist in every tumor patient. It is a "super suicide squad" whose body mobilizes the immune army to penetrate into the tumor tissue after discovering cancer cells in the body, and has the strongest recognition, resistance and attack effects on tumors. After reaching the inside of the tumor, the tumor cells are directly killed by releasing cytotoxins. It should be noted that the number of TIL cells present in the tumor directly affects the prognosis of patients. Generally, patients with a large number of TIL cells have better prognosis. Based on this, Rosenberg, the American immune master, and his team developed the TIL therapy : Isolate TIL cells from tissues near the tumor, add growth factor IL-2 for large-scale amplification in vitro, and then return to the patient's body to expand the immune response and treat primary or secondary tumors. This therapy will inject T-cell immune army that can accurately identify and kill cancer cells into the body. It is an individualized anti-cancer therapy tailored based on each cancer patient . It has polyclonalization and can specifically recognize a variety of neogenic antigens, individualization, high specificity, durability, and can form immune memory after infusion. This means that we can use our own immune cells to kill tumors, which is a safer and more effective new immunotherapy.
In fact, many patients with advanced cancer may not have targeted mutations. Therefore, chemotherapy and immunotherapy have become the main treatment options. The emergence of this new immunotherapy will bring new hope to cancer patients.
In addition, there are many new immunotherapy research at home and abroad. wants to seek help from other new treatment technologies at home and abroad, and if economic conditions allow, you can consult the Global Cancer Doctor Network Medical Department. We also look forward to the TILs therapy being approved for marketing as soon as possible, bringing more treatment options to patients.
Reference:
https://ccr.cancer.gov/news/article/using-the-immune-system-to-fight-and-win-the-battle-against-cervical-cancer
