Many people must have experienced insomnia, just like what is said in ancient poems: "Carefree, tossing and turning." It seems that the experience of insomnia has a history of thousands of years, and even the ancients are not immune to it. Regarding the symptoms of insomnia, many people have different experiences.
Some people just can't fall asleep when they have insomnia; some people wake up sometimes and fall asleep sometimes... It makes it difficult to calm down and brings a lot of pain to people.
In fact, if you often suffer from insomnia, it is very likely that you are lacking three kinds of vitamins in your body. So, which vitamins are missing? Below, I will reveal the answer to you.
1. The latest research finds: Appropriate supplementation of and vitamin E can increase the presentation of tumor antigens and enhance the therapeutic effect!
The operation of the human immune system is inextricably linked to the body's nutritional status. Nutritional intake will affect the anti-tumor immune response and the effectiveness of cancer immunotherapy. Studies have shown that ingesting large doses of vitamin C can increase the infiltration of T cells , thereby improving the effectiveness of immune checkpoint therapy.
In fact, in addition to vitamins, the existence of trace elements is closely related to the growth and metastasis of tumors. Existing research shows that although a low-magnesium diet can significantly inhibit tumor growth in mice, it accelerates the metastasis of cancer cells. Therefore, the impact of nutritional intake on tumors must be paid attention to.
In April 2022, scientists from the United States published a latest research paper in the journal "Cancer Discovery". This paper claims that dietary supplements of vitamin E can promote the antigen presentation of T cells to tumors, thereby activating a large number of T cells and stimulating the immune system to attack tumors.
According to existing research, vitamin E has a strong antioxidant effect and is often used to protect the skin and resist aging. It also plays an important role in preventing cardiovascular and cerebrovascular diseases and regulating the function of the reproductive system. In addition, vitamin E has a positive effect on the immune regulation of animals and humans, and affects a variety of cells in the immune system.
Researchers conducted an in-depth analysis of the electronic health records of patients with a series of cancers, including melanoma and breast cancer, and found that taking vitamin E during treatment can significantly improve the overall survival rate of these patients. At the same time, the researchers found that combined treatment with vitamin E and immune checkpoint therapy can effectively inhibit the growth of mammary tumors and melanoma in mice.
It is obvious that the presence of vitamin E can make the body better respond to immune checkpoint therapy and enhance the therapeutic effect on patients. After this, the researchers conducted in vitro experiments, and soon they discovered that vitamin E could activate dendritic cells and also cause T cells to proliferate in large numbers.
For mice with breast cancer, when treated with vitamin E, the infiltration of dendritic cells in the tumor tissue increased and showed activation characteristics, and the proliferation of T cells was also promoted. In addition, clinical research data can also be found that in patients with melanoma, bladder cancer , the higher the level of dendritic cell activation, the better the effect of immune checkpoint therapy.
Therefore, the researchers concluded that it is through the stimulation of dendritic cells that vitamin E significantly enhances the effect of immune checkpoint therapy. Soon, this inference was verified in experiments, confirming that the inference was correct.
In summary, taking vitamin E can effectively improve the treatment effect of cancer, reduce the pain of cancer patients, and improve the survival rate of cancer patients.
2. BMJ: When people reach middle age, insist on supplementing vitamin B9 and say goodbye to Alzheimer's ?
In March 2022, a latest study published in the journal "Evidence Based Mental Health" showed that low levels of and in the blood may be related to the increased risk of Alzheimer's disease and premature death in the elderly.
Researchers said that the elderly should regularly check their folic acid levels and pay attention to timely supplementation of folic acid.In addition, studies have found that as age increases, the level of folic acid in the blood of the human body will also decrease. According to statistics, up to 20% of elderly people have lower than normal folic acid levels.
According to existing research, if the folic acid content in the body is too low, the conduction of nerve signals in the brain will be affected and the cognitive level will decline. Therefore, there is reason to suspect that low folic acid content may be one of the risk factors for Alzheimer's disease.
The researchers selected the medical records of more than 27,000 Israelis as a study sample. The ages of these participants ranged from 60 to 75. This study began in 2013 and ended in 2017.
At the start of the trial, the participants had been free of dementia for at least 10 years before having their blood folate tested, and their medical records were monitored for dementia and death during the trial.
Experimental data show that approximately 3,418 subjects have insufficient folic acid levels in their bodies. research shows that insufficient folic acid in the body will indeed significantly increase the risk of Alzheimer's disease and death. After calculation, among people with insufficient folic acid, the incidence rate of Alzheimer's disease is 7.96/10,000 people/year, and the risk of death is 19.20/10,000 people/year.
For normal people, the incidence rate of Alzheimer's disease is 4.24/10,000 people/year, and the risk of death is 5.36/10,000 people/year.
If this data is converted into a percentage, for folate deficiency patients, the incidence of Alzheimer's disease is about 3.5%, and the mortality rate is about 8%; for normal people, the incidence of Alzheimer's disease is about 3.5%. The mortality rate is 3% and the mortality rate is about 4%.
After taking into account the impact of diseases such as diabetes and depression , researchers found that people with folic acid deficiency had a 68% higher risk of being diagnosed with Alzheimer's disease and a three times higher risk of death. The researchers emphasized that the study was only an observational study and the underlying cause has not yet been determined.
However, folic acid deficiency may affect homocysteine levels and increase the risk of vascular dementia. The reason for may be that the neuronal DNA repair process is damaged, making it susceptible to oxidative damage, which in turn accelerates the aging and damage of brain cells.
In summary, serum folic acid concentration may serve as a biomarker and have a certain effect on changing the risk of Alzheimer's disease and premature death in the elderly. In addition, it is recommended that the elderly should regularly check the folic acid levels in their bodies.
3. Frequent insomnia and poor sleep are probably due to the lack of these 3 vitamins. Supplement them in time to have a sound sleep
As mentioned earlier, people who often suffer from insomnia are mostly due to the lack of 3 vitamins in the body. So which 3 vitamins are they? What about vitamins? Below, I will reveal the secret for you.
vitamin B1.
Research shows that vitamin B1 is a drug that can be used to treat neuroinflammation. It can maintain the body's internal carbohydrate metabolism balance and the normal function of the nervous system . In addition, taking an appropriate amount of vitamin B1 can eliminate fatigue, so vitamin B1 is also known as the "spiritual vitamin", so many insomnia patients use it as the first choice drug to treat insomnia.
This is because vitamin B1 can promote the development of the nervous system, especially the growth and development of the human brain. Therefore, when people are deficient in vitamin B1, they often suffer from neuritis , neurasthenia and other diseases, and will easily suffer from insomnia. Condition.
In addition, lack of vitamin B1 in the body will also cause indigestion problems. This is because vitamin B1 can also regulate the body's metabolism of carbohydrates and promote the body's digestion of food. Therefore, when vitamin B1 is lacking in the body, patients often suffer from indigestion.
Vitamin B6.
Research shows that when the human body has vitamin B6, it will cause the nervous system to be in a highly excited state, making it difficult to fall asleep at night, leading to insomnia. In addition, when the human body lacks vitamin B6, it will also cause symptoms in the patient's skin, intestines and other organs and tissues.
When a patient lacks vitamin B6, the patient's skin will suffer from folliculitis , cheilitis , acne and other skin diseases. Although the patient's symptoms will be relieved after applying the ointment, the symptoms will not be cured, and the diseased parts will be affected. Redness and dryness may also occur.
In addition, when a patient is deficient in vitamin B6, the patient's intestinal tract will have adverse reactions, such as nausea and vomiting. Foods such as orange peels and hawthorns will not help. However, after supplementing an appropriate amount of vitamin B6, the symptoms can be significantly relieved. .
Vitamin B12.
Vitamin B12, like vitamin B1 and vitamin B6, are vitamins that play an extremely important role in the nervous system. Research shows that the presence of vitamin B12 enables human nerves to be fully nourished, thereby ensuring the normal operation of the nervous system.
In addition, the presence of vitamin B12 can help the growth and development of red blood cells , so that the body's qi and blood are sufficient, and it can also secrete serotonin to regulate people's emotions. However, once vitamin B12 is lacking, a person's Qi and blood will be insufficient, the nerves will become more sensitive, and even symptoms of anemia will occur, leading to an increased risk of insomnia.
Extended reading: What is the difference between staying up late and insomnia?
Some people often confuse staying up late with insomnia, but they don’t know that staying up late and insomnia are not the same. I will tell you the difference between the two below.
Staying up late means falling asleep too late and sleeping for too short a time. Going to bed too late refers to being more than half an hour later than the bedtime point (referring to everyone’s relatively fixed bedtime point), while going to bed too short means sleeping less than 6 hours.
The essence of insomnia is passive staying up late. Insomnia patients often have difficulty falling asleep (it takes more than half an hour to fall asleep) and sleep time is less than 6 hours. In addition, patients have poor sleep quality and wake up at least twice during the night. At the same time, insomnia will cause the patient's work status to deteriorate sharply during the day, and symptoms such as memory loss and social ability will also occur.
Reference:
Wang Pengjin. Effect of self-prepared Jieyu Anmian Decoction and vitamin B_1 tablets on sleep quality in patients with insomnia due to liver stagnation and kidney deficiency [J]. World Journal of Sleep Medicine , 2021, 8(05): 792-793.
Shi Haijun, Zhai Nina, Liu Zhen, He Li, Qing Maocai, Tursun Kurban. Analysis of the efficacy and mechanism of vitamin B_6 combined with venlafaxine on postherpetic neuralgia [J ]. Chinese Prescription Drugs, 2021, 19(10): 118-120.
Guo Xia. Expression of homocysteine in patients with gestational diabetes and its relationship with folic acid, vitamin B12, and blood lipids [J]. Xinjiang Medicine, 2022,52(03):305-307.
