Regarding third-generation in vitro fertilization, there are many professional terms, which often make people confused.
"Third generation test-tube baby" is a common name. The previous scientific name is "preimplantation genetic diagnosis/screening". is to conduct embryology for parents with chromosomal diseases and genetic diseases who have genetic risks. genetics diagnostics for .
What is PGS?
PGS refers to: Preimplantation Chromosome Screening (PGS/PGT-A), which mainly screens for embryo chromosome abnormalities (number and structure) .
In test tube baby , after egg collection, fertilization, and embryo formation, the culture is continued until the blastocyst stage, the embryo is biopsied to obtain a small number of embryonic cells, and then its chromosomes are analyzed. understands the number of chromosomes. And whether the structure is abnormal .
Applicable people
Habitual miscarriage , repeated IVF failure, elderly women (depending on conditions), chromosomal abnormalities family history, want to avoid fetal chromosomal abnormalities, want to select a single embryo for implantation in the case of multiple embryos Those who get pregnant as early as possible...etc.
The risks and matters that need to be paid attention to are as follows:
1. In about 5-6% of cases (the rate will be higher in elderly patients), the embryos all stop growing before they form blastocysts, resulting in no embryos for screening; after testing , it may happen that there are no normal embryos and no embryos can be implanted.
2. Due to the heterogeneity of embryo chromosomes, about 0-2.5% of normal embryos will be judged as abnormal embryos and fail to implant; necessary prenatal examinations are still required after pregnancy, such as amniocentesis etc. cannot be omitted.
What is PGD?
PGD refers to: Preimplantation Genetic Diagnosis (PGD/PGT-M), which allows couples at high risk of genetic abnormalities to avoid giving birth to a fetus with genetic defects. To put it simply, prevents genetic diseases from being passed on to the next generation .
In in vitro fertilization, after eggs are retrieved, fertilized, and embryos are formed, and then continue to be cultured to the blastocyst stage, the embryos are biopsied to obtain a small amount of embryonic cells, and then tested to see if they have the gene disease .
Applicable people
Couples with a family history of single-gene hereditary diseases, couples with concerns about single-gene hereditary diseases (note: there is currently no scientific way to perform embryonic genetic testing for polygenic genetic diseases and unexplained genetic diseases).
Common single-gene diseases include: thalassemia, spinal muscular atrophy, ankylosing spondylitis, polycystic kidney disease, retinoneuroblastoma, cerebellar atrophy, and neurofibromatosis type 1. .....and hundreds more.
statement: The above content was originally created by "Good Pregnancy, Good Life" and is not allowed to be reproduced without authorization. The relevant views on infertility and in vitro fertilization are for health reference only. Regarding the actual condition of the disease, it is subject to face-to-face discussion with the doctor and cannot replace the face-to-face meeting with the doctor. Diagnosis, please be informed!
