[Reprint] Adv. Mater. | Biomineralization dual-enzyme nanoparticles regulate tumor sugar metabolism and induce tumor cell pyrolysis and anti-tumor immunotherapy
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*This article was first published on the "Nanozymes" public account, October 19, 2022
* Editor: Du Jiang
In recent years, tumor immunotherapy has developed rapidly, activates the immune system and produces a long-term anti-tumor immune response. However, the response rate of tumor immunotherapy is low, for example, immune checkpoint therapy has less than 20% response rate in most tumors. Therefore, in clinical trials of tumor therapy, tumor immunotherapy is usually combined with chemotherapy or radiotherapy. However, chemotherapy and radiotherapy can have serious side effects on patients, so finding safe and effective treatments combined with immunotherapy is crucial.
Recently, the team of Academician Chen Xuesi of Changchun Institute of Acupuncture and Acupuncture and Acupuncture and Acupuncture and Acupuncture and Acupuncture and Acupuncture and Acupuncture and Acupuncture and Acupuncture and Acupuncture and Acupuncture and Acupuncture and Acupuncture and Acupuncture and Acupuncture and Acupuncture and Acupuncture and Acupuncture and Acupuncture and Acupuncture and Acupuncture and Acupuncture and Acupuncture and Acupuncture and Acupuncture and Development have recently developed a nanoparticle with dual enzyme activity (GOx-Mn/HA). The core principle of this strategy is to hybridize nanoenzymes (Mn-NP) and glucose oxidase (GOx) through biomineralization methods to achieve automagnification and regulation of tumor glucose metabolism. On the one hand, Mn-NP catalyzes H2O2 to generate O2; the generated O2 can promote the consumption capacity of GOx in nanoparticles and effectively regulate sugar metabolism . On the other hand, the H2O2 produced in the latter reaction is also conducive to the catalytic reaction of Mn-NP. The hybridization of nanoenzymes and GOx realizes the connection of two catalytic reactions, which has the ability to cyclically amplify glucose consumption. Moreover, studies have shown that GOx-Mn/HA can upregulate the expression of programmed death ligand 1 (PD-L1) on the surface of tumor cells, and can also induce tumor cell pyrolysis, thereby activate anti-tumor immunotherapy. Therefore, this paper proposes a strategy to treat tumors by regulating tumor glucose metabolism in combination with anti-PD-L1 therapy. This greatly inhibited the development of the tumor and significantly prolonged the survival time of the mice. Combination therapy also has significant immune memory effects, successfully inhibiting tumor recurrence and metastasis. The combined immune checkpoint blocking therapy proposed in this work is an innovative, safe, low-toxic and efficient anti-tumor strategy with good clinical application prospects. The work was published in " Advanced Materials" under the title "Biomineralized two-enzyme nanoparticles regulated tumor glycocometabolism inducing tumor cell pyroptosis and robust anti-tumor immunotherapy" (DOI: 10.1002/adma.202206851). The first author of the article is Zhang Sijia, a doctoral student at the Changchun Institute of Yinghua, and Tian Huayu, , the corresponding author of the article , . The research has been supported by the National Natural Science Foundation of China, the Ministry of Science and Technology Key R&D Plan and the Jilin Province Science and Technology Development Plan.
Figure 1. Preparation method of biomineralized dual enzyme nanoparticles and its regulation of tumor glucose metabolism induces tumor cell pyroptosis and anti-tumor immunotherapy
Figure 2. Anti-tumor effects of regulating tumor glucose metabolism combined with immune checkpoint blocking therapy
This work is one of the latest progress of the team's recent research on nanomaterials in the field of tumor immunotherapy.In order to improve the effect of tumor immunotherapy, the team has successively developed different types of nanomaterials to promote the immune circulation at different stages, and achieved efficient anti-tumor immunotherapy effects. For example, using a new cationic polymer as a carrier to silencing the PD-L1 gene combined with epigenetic regulation therapy (Nature Communications 2021, 12(1), 1-19), and using porphyrin-based COF to prepare nanosound sensitizer combined with immune checkpoint blocking therapy ( Advanced Materials 2022, e2205924), using PEI/CaCO3 as a vector to prepare nanovaccine combined gene-mediated extracellular matrix clearance therapy (Biomaterials 2020, 252, 120114), using biomineralization method to prepare personalized nanovaccine combined with immune checkpoint blocking therapy (Biomaterials 2022, 289, 121794), and immunococktail therapy based on nanomedicine-loading system (Science Advances 2020, 6(40), eabc7828 and Nano Letters 2022, 2c02724), etc. The team's work has promoted the research progress of nanomaterials in the field of tumor immunotherapy and has good application prospects.
Original link:
https://onlinelibrary.wiley.com/doi/10.1002/adma.202206851
