Ginseng saponin is an steroid compound (triterpene saponin), which is mainly found in ginseng genus medicinal materials, and is the active ingredient in ginseng. Unlike other nutrients in ginseng that promote cancer cell growth, ginseng saponin not only can not be absorbed by cancer cells, but also effectively inhibits its growth ; its monomer affects multiple metabolic pathways and is also very complex in its efficacy.
ginseng saponin has been widely used in cancer adjuvant treatment , among which the most commonly used ginseng saponin are Rg3 and Rh2. So, should we choose ginseng saponin Rg3 or ginseng saponin Rh2 to assist in anti-cancer?
Difference between ginseng saponin Rg3 and Rh2
1, ginseng saponin Rh2 and Rg3 are the first first generation ginseng saponin , which was first used in anti-cancer. Rg3 was developed into anti-cancer products by domestic pharmaceutical companies in 2000. Rh2 was first developed into an anti-cancer product by domestic pharmaceutical companies in 2006, and has since become the main force in anti-cancer of ginseng saponin.
It is worth mentioning that the only ginseng saponin drug in China with prescription drug qualifications is successfully developed by two doctors in pharmacy, R&F and Luqi. uses Rg3 as the main ingredient . It is tested and approved by National Medical Products Administration and can effectively fight tumors.
2. In terms of molecular structure, ginseng saponin Rh2 is one less sugar molecule than Rg3. Ginseng saponin Rh2 has a smaller molecular weight, and is more conducive to the intestinal absorption and utilization of .
3. According to the results determined by Canadian scientists in the experiment, the anti-cancer effect of ginseng saponin Rh2 is stronger than that of Rg3. Therefore, even if Rg3 is used in anti-cancer applications earlier, it has the qualifications for prescription drugs, and its popularity and wide application are lower than Rh2.
anti-tumor mechanism of action of ginseng saponins Rg3 and Rh2
1
Rg3 anti-tumor mechanism of action
Angiogenesis is necessary for malignant solid tumors to further grow after breaking through the epithelial basement membrane. Tumors rely on neovascularization to obtain nutrients, thereby growing and expanding. Rg3 can inhibit tumor neovascularization , effectively blocking the channels for tumor absorption of nutrients and diffusion and metastasis.
Figure Note: Tumor neovascularization
①Rg3 can inhibit the proliferation and migration of vascular endothelial cells of tumor and promote its apoptosis;
②Rg3 can inhibit the conduction pathway of tumor angiogenesis factor signal;
③Rg3 can promote tumor angiogenesis Inhibitor expression and activity;
④Rg3 can inhibit the degradation of extravascular matrix and inhibit the formation of angiogenesis basement membrane;
⑤Rg3 can inhibit the formation of tumor microvascular;
⑥Rg3 can inhibit the mimicry of angiogenesis;
⑦Rg3 can regulate the related genes of tumors.
2
Rh2 Anti-tumor action mechanism
①Rh2 can reduce the activity of telomerase in tumor cells, making the telomeres of cancer cells unable to be intensive Maintaining the original length, causes cancer cells to apoptosis and cannot proliferate infinitely;
②Tumor metastasis mainly involves the generation of neovascularization and lymphatic vessels. Rh2 can inhibit the generation of neovascularization and lymphatic vessels of tumor , reducing the possibility of tumor metastasis;
③Rh2 can improve and improve the body's immune function through various ways. improves the body's immune function and exerts an anti-tumor effect. It has a protective effect on the immune system. Its major feature is its superiority to other anti-tumor drugs;
④General chemotherapy drugs are not easy to enter cancer cells. There is a P-glycoprotein in cancer cells that can excrete chemotherapy drugs, causing cancer cells to treat chemotherapy. The drug production has poor tolerance. Rh2 can be used as a tumor resistance reversal agent to improve the anti-tumor activity of chemotherapy drugs ;
⑤Rh2 combined with low-concentration chemotherapy drugs can achieve the effect of using high-concentration chemotherapy drugs. By reducing the dosage of chemotherapy drugs, the effect of the drug is maintained, so that reduces the toxicity of .
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