Copyright statement: This article was first published by Slim Dragon Health , a fierce critic of China's obesity problem. I have entrusted a "rights protection knight" to carry out rights protection actions for my article.
Disclaimer : The following text does not make any medical advice, it is only for information sharing. Please proceed under the guidance of professionals.
Please feel free to forward it to your circle of friends . If you need to repost to , please contact the backend.
The number of words edited in this article 
196 words . The estimated reading time is 0 minute.
Are you afraid of fruits? Some friends may find it strange: fruits are sour and sweet, so there is nothing to be afraid of.
The fruit I am most afraid of is pineapple. This is because when I was a child, eating pineapple always felt like it pricked my mouth, making it numb. Once, it even "pricked" me and caused bleeding...
It was this experience that left a great psychological shadow on my young mind;
When I grew up, I realized that all this was caused by a substance in the pineapple - Bromelain (bromelain) .
This guy who "bited" my mouth actually appeared on the health care product shelf one day? ! What the hell is going on.
What is Bromelain
Pineapple is a fruit from South America and a precious part of Hawaiian folk medicine. It is one of the richest sources of bromelain in the world.
It consists of several endopeptidases and compounds, such as phosphatase , glucosidase , peroxidase , cellulase , caramelase and protease inhibitors.
And our protagonist today - bromelain , is not an enzyme extracted from the pulp of pineapple, because the content is very small, but is extracted from the pineapple stem or core .
Pineapple is widely used in folk medicine to treat everything from indigestion to allergies. It is not only rich in bromelain, but also vitamin C, vitamin B1, potassium, manganese and phytonutrients .
While pineapple has many benefits, the secret to its miraculous abilities lies in the enzyme bromelain.
Bromelain has many immunomodulatory and anti-inflammatory mechanisms , including effects on cytokines , platelet aggregation and fibrin formation .
→ why numbness
Some of the anti-inflammatory effects of bromelain have been attributed to proteolysis, fibrinolysis , gelatinase and collagenase activity , all of which contribute to bromelain wounds. Healing ability.
If you eat too much pineapple, bromelain can also dissolve fibrin and blood clots in tissues, irritate the lips and oral cavity, and cause mouth pain and lip bleeding.
This is why it happens that when you eat pineapple in , the pineapple also "eats" your .
Bromelain is a substance that can cause allergies to the human body. If you peel and cut the pineapple into pieces, soak it in light salt water.
Not only does taste sweeter than , but the bromelain in it, after being soaked in salt water, the internal allergenic structure will be destroyed, so that the processed pineapple will not cause damage to the lips.
Mechanism of action of bromelain
→ Immunomodulatory, anti-inflammatory and analgesic
Bromelain has many immunomodulatory and anti-inflammatory mechanisms , including effects on cytokines, platelet aggregation and fibrin formation.
Some of the anti-inflammatory effects of bromelain are attributed to proteolytic, fibrinolytic, gelatinase and collagenase activities, all of which contribute to bromelain's wound healing abilities .
Bromelain can accelerate the recovery of blood perfusion and oxygen pressure in wound tissue ; controls the expression of tumor necrosis factor-alpha ; and increases the expression of transforming growth factor beta.
All of these mechanisms may also improve allergies and systemic inflammation and help reduce pain .
An animal model of allergic airway disease showed that bromelain significantly reduced bronchial leukocytes and eosinophils and reduced CD4 and CD8 T cell activation in the bronchi compared with controls.
Bromelain also reduces the pro-inflammatory interleukins (IL)-4, -12 and -17 and interferon-γ, The reduction of these factors contributes to the broad analgesic and anti-inflammatory effects of bromelain .
Tissue culture studies obtained from biopsy tissue from patients with ulcerative colitis have shown that bromelain reduces the release of inflammatory cytokines from colonic mucosal cells, including granulocyte colony-stimulating factor, interferon gamma and tumor necrosis factor.
Oral administration of bromelain may also reduce the production of pro-inflammatory prostaglandin E2 (PGE2), and pain-related peptide substance P (SP), thereby further enhancing anti-inflammatory and analgesic mechanisms .
→ activates into fibroblasts to help heal
Another focus of bromelain research is the activation of fibroblasts . All soft tissue healing involves the activation of fibroblasts.
Fibroblasts are recruited to damaged tissue sites to help cells adhere to each other. Eventually, damaged cells are replaced by functional cells. The type of functional cells depends on the type of injured tissue.
If the damage to the cells is too severe and the cells cannot continue to survive, they undergo apoptosis and replacement fibroblasts migrate to the injured area and are formed by precursor cell types.
However, if fibroblasts are excessive, or inappropriately recruited , it can lead to organ fibrosis, loss of vascular elasticity , or excessive scarring or scarring .
These conditions can also occur in excessive autoimmune reactions, such as arthritis and connective tissue diseases , leading to fibrosis, loss of function, and pain.
Bromelain can help control excessive fibrosis by promoting cell quiescence, promoting cell recovery, reducing elevated IL-6 levels, and reducing apoptosis.
→ Affects leukocyte activity
Bromelain was also found to interfere with the neutrophil binding site of P-selectin, an endogenous lectin.
thereby limits neutrophil binding to substrates, reducing inflammation, and reduces glycosylation of cells in diabetes, and other inflammatory conditions.
Bromelain may affect various leukocyte surfaces, thereby affecting their activation and migration, neutrophil chemotaxis, and leukocyte adhesion to blood vessels.
These are all mechanisms that contribute to the anti-edematous, anti-inflammatory and anti-fibrotic effects of . Cell surface components are also affected by bromelain, such as l-selectin .
→ Reduce the damage caused by strenuous exercise
Moderate exercise has a positive effect on the immune system, but the load of strenuous exercise is too great, which will damage the immune system.
Marathon running, for example, causes inflammation, increases , and is associated with an increased incidence of upper respiratory tract infections (URIs); it may also cause trauma to muscles and promote a prothrombotic state. Copyright statement: This article was first published by Slim Dragon Health , a fierce critic of China's obesity problem. I have entrusted a "rights protection knight" to carry out rights protection actions for my article. Disclaimer : The following text does not make any medical advice, it is only for information sharing. Please proceed under the guidance of professionals. Please feel free to forward it to your circle of friends . If you need to repost to , please contact the backend. The number of words edited in this article 196 words . The estimated reading time is 0
Are you afraid of fruits? Some friends may find it strange: fruits are sour and sweet, so there is nothing to be afraid of.
The fruit I am most afraid of is pineapple. This is because when I was a child, eating pineapple always felt like it pricked my mouth, making it numb. Once, it even "pricked" me and caused bleeding...
It was this experience that left a great psychological shadow on my young mind;
When I grew up, I realized that all this was caused by a substance in the pineapple - Bromelain (bromelain) .
This guy who "bited" my mouth actually appeared on the health care product shelf one day? ! What the hell is going on.
What is Bromelain
Pineapple is a fruit from South America and a precious part of Hawaiian folk medicine. It is one of the richest sources of bromelain in the world.
It consists of several endopeptidases and compounds, such as phosphatase , glucosidase , peroxidase , cellulase , caramelase and protease inhibitors.
And our protagonist today - bromelain , is not an enzyme extracted from the pulp of pineapple, because the content is very small, but is extracted from the pineapple stem or core .
Pineapple is widely used in folk medicine to treat everything from indigestion to allergies. It is not only rich in bromelain, but also vitamin C, vitamin B1, potassium, manganese and phytonutrients .
While pineapple has many benefits, the secret to its miraculous abilities lies in the enzyme bromelain.
Bromelain has many immunomodulatory and anti-inflammatory mechanisms , including effects on cytokines , platelet aggregation and fibrin formation .
→ why numbness
Some of the anti-inflammatory effects of bromelain have been attributed to proteolysis, fibrinolysis , gelatinase and collagenase activity , all of which contribute to bromelain wounds. Healing ability.
If you eat too much pineapple, bromelain can also dissolve fibrin and blood clots in tissues, irritate the lips and oral cavity, and cause mouth pain and lip bleeding.
This is why it happens that when you eat pineapple in , the pineapple also "eats" your .
Bromelain is a substance that can cause allergies to the human body. If you peel and cut the pineapple into pieces, soak it in light salt water.
Not only does taste sweeter than , but the bromelain in it, after being soaked in salt water, the internal allergenic structure will be destroyed, so that the processed pineapple will not cause damage to the lips.
Mechanism of action of bromelain
→ Immunomodulatory, anti-inflammatory and analgesic
Bromelain has many immunomodulatory and anti-inflammatory mechanisms , including effects on cytokines, platelet aggregation and fibrin formation.
Some of the anti-inflammatory effects of bromelain are attributed to proteolytic, fibrinolytic, gelatinase and collagenase activities, all of which contribute to bromelain's wound healing abilities .
Bromelain can accelerate the recovery of blood perfusion and oxygen pressure in wound tissue ; controls the expression of tumor necrosis factor-alpha ; and increases the expression of transforming growth factor beta.
All of these mechanisms may also improve allergies and systemic inflammation and help reduce pain .
An animal model of allergic airway disease showed that bromelain significantly reduced bronchial leukocytes and eosinophils and reduced CD4 and CD8 T cell activation in the bronchi compared with controls.
Bromelain also reduces the pro-inflammatory interleukins (IL)-4, -12 and -17 and interferon-γ, The reduction of these factors contributes to the broad analgesic and anti-inflammatory effects of bromelain .
Tissue culture studies obtained from biopsy tissue from patients with ulcerative colitis have shown that bromelain reduces the release of inflammatory cytokines from colonic mucosal cells, including granulocyte colony-stimulating factor, interferon gamma and tumor necrosis factor.
Oral administration of bromelain may also reduce the production of pro-inflammatory prostaglandin E2 (PGE2), and pain-related peptide substance P (SP), thereby further enhancing anti-inflammatory and analgesic mechanisms .
→ activates into fibroblasts to help heal
Another focus of bromelain research is the activation of fibroblasts . All soft tissue healing involves the activation of fibroblasts.
Fibroblasts are recruited to damaged tissue sites to help cells adhere to each other. Eventually, damaged cells are replaced by functional cells. The type of functional cells depends on the type of injured tissue.
If the damage to the cells is too severe and the cells cannot continue to survive, they undergo apoptosis and replacement fibroblasts migrate to the injured area and are formed by precursor cell types.
However, if fibroblasts are excessive, or inappropriately recruited , it can lead to organ fibrosis, loss of vascular elasticity , or excessive scarring or scarring .
These conditions can also occur in excessive autoimmune reactions, such as arthritis and connective tissue diseases , leading to fibrosis, loss of function, and pain.
Bromelain can help control excessive fibrosis by promoting cell quiescence, promoting cell recovery, reducing elevated IL-6 levels, and reducing apoptosis.
→ Affects leukocyte activity
Bromelain was also found to interfere with the neutrophil binding site of P-selectin, an endogenous lectin.
thereby limits neutrophil binding to substrates, reducing inflammation, and reduces glycosylation of cells in diabetes, and other inflammatory conditions.
Bromelain may affect various leukocyte surfaces, thereby affecting their activation and migration, neutrophil chemotaxis, and leukocyte adhesion to blood vessels.
These are all mechanisms that contribute to the anti-edematous, anti-inflammatory and anti-fibrotic effects of . Cell surface components are also affected by bromelain, such as l-selectin .
→ Reduce the damage caused by strenuous exercise
Moderate exercise has a positive effect on the immune system, but the load of strenuous exercise is too great, which will damage the immune system.
Marathon running, for example, causes inflammation, increases , and is associated with an increased incidence of upper respiratory tract infections (URIs); it may also cause trauma to muscles and promote a prothrombotic state.
Studies in marathon runners have shown that bromelain exerts anti-inflammatory and fibrinolytic effects, normalizes interleukins and immunoglobulin A, thereby normalizing inflammation caused by strenuous exercise .
Another study showed that bromelain can reduce skeletal muscle damage caused by unaccustomed exercise .
Bromelain has also been shown to reduce fatigue and has been shown to maintain a trend in serum testosterone concentrations in endurance athletes.
What are the uses of bromelain
→ May help prevent cancer
Studies have found that bromelain has natural anti-cancer effects, including promoting apoptotic cell death and preventing tumor growth .
Animal studies have shown that it can induce the production of different cytokines, have anti-metastatic effects, and inhibit cancer cell metastasis by reducing platelet aggregation.
→ Helps treat digestive disorders
Bromelain is an enzyme that specifically helps digest proteins , and has been found to help the body absorb nutrients and even medications more efficiently.
Studies have shown that it can reduce colon inflammation, reduce the secretion of pro-inflammatory cytokines that damage the lining of the intestines, and is very effective in treating tissue within the gastrointestinal tract, making it beneficial for people with the following gastrointestinal problems:
- inflammatory bowel disease;
- ulcerative colitis;
- dyspepsia, or peptic ulcer caused by Helicobacter pylori infection peptic ulcer;
- bowel cancer;
- constipation;
- Crohn's disease;
- heartburn;
- diarrhea;
→ Promotes faster recovery after surgery or wounds
The anti-inflammatory properties of bromelain make it an excellent natural alternative to pain medications such as aspirin.
One study evaluated the ability of bromelain to treat patients who had had their wisdom teeth removed, finding that it promoted wound healing and helped reduce pain and swelling in patients after surgery.
Most patients who have their wisdom teeth removed will experience significant symptoms after surgery. Unfortunately, antibiotics and painkillers are not always effective in preventing infection or other discomfort during the healing process.
Of the 80 people who participated in the study, those who took bromelain reported significantly less postoperative pain, swelling and even redness compared to a control group prescribed generic painkillers.
→ Fights allergies and asthma
A study investigated how bromelain affects mice with asthma and found that bromelain can reduce allergic sensitization , and prevent other inflammatory responses that affect the airways. Develop .
These findings suggest that this enzyme helps regulate the entire immune system, which could help prevent allergies and an overly sensitive immune system by addressing the underlying causes.
observed in the study that CD11c (+) dendritic cells, and DC44 antigen-presenting cells, did not increase after bromelain supplementation, which is the root cause of its ability to combat asthma and allergies.
→ Help prevent or treat sinusitis
Researchers at the University of Cologne in Germany found the following bromelain benefits over three months of treatment in 12 patients who had already undergone sinus surgery:
Improvements in total symptom scores, The overall score of rhinoscope improved, the overall quality of life improved, and no adverse reactions were reported.
Since surgery is often ineffective in treating sinusitis, this study offers a lot of hope for people with chronic sinus problems.
→ Helps reduce joint pain
Due to its powerful anti-inflammatory and analgesic properties , bromelain is ideal for relieving acute or chronic joint pain .
The journal Alternative Medicine in Health and Medicine published a research trial that evaluated 42 patients with osteoarthritis, a degenerative spine, or painful joint disease.
When patients were given 650mg bromelain capsules 2-3 times daily on an empty stomach, researchers found that pain was reduced by 60% in participants with acute pain and by more than 50% in participants with chronic disease .
→ May Help with Weight Loss
Its effects on weight management and fat cells are still being studied, but there is reason to believe that it may aid in weight loss due to its anti-inflammatory effects, pain relief, and ability to improve digestion.
According to a 2017 article published in PLOS One, bromelain is used as an anti-obesity alternative drug.
Research has found that bromelain helps downregulate fat cells' fatty acid-binding protein , fatty acid synthase, and lipoprotein lipase .
can also inhibit lipogenesis and reduce triglyceride accumulation .
The key Slender Dragon said
I didn’t expect that this little pineapple that some people love and some hate, actually hides such powerful ingredients.
This enzyme, which only exists in pineapples, can fight inflammation, allergies, analgesia and aid digestion. In addition to its medical value, it can also be used as a meat tenderizer in the kitchen.
However, I do not recommend eating pineapple to supplement bromelain, because the sugar content of pineapple is still very high. I don’t need to say more about the disadvantages of consuming too much fructose.
Moreover, this enzyme mainly exists in the stems and core of pineapple, but very little in the pulp. Therefore, it is not cost-effective to supplement it by eating pineapple.
You can try it through supplements. If you want to improve digestion, you should take bromelain supplements with meals, but for other health conditions, you should take them on an empty stomach.
Shoulong has not tried this supplement yet, so I won’t recommend it to you. If you have tried it, you can share it in the comment area.
→ Helps reduce joint pain
Due to its powerful anti-inflammatory and analgesic properties , bromelain is ideal for relieving acute or chronic joint pain .
The journal Alternative Medicine in Health and Medicine published a research trial that evaluated 42 patients with osteoarthritis, a degenerative spine, or painful joint disease.
When patients were given 650mg bromelain capsules 2-3 times daily on an empty stomach, researchers found that pain was reduced by 60% in participants with acute pain and by more than 50% in participants with chronic disease .
→ May Help with Weight Loss
Its effects on weight management and fat cells are still being studied, but there is reason to believe that it may aid in weight loss due to its anti-inflammatory effects, pain relief, and ability to improve digestion.
According to a 2017 article published in PLOS One, bromelain is used as an anti-obesity alternative drug.
Research has found that bromelain helps downregulate fat cells' fatty acid-binding protein , fatty acid synthase, and lipoprotein lipase .
can also inhibit lipogenesis and reduce triglyceride accumulation .
The key Slender Dragon said
I didn’t expect that this little pineapple that some people love and some hate, actually hides such powerful ingredients.
This enzyme, which only exists in pineapples, can fight inflammation, allergies, analgesia and aid digestion. In addition to its medical value, it can also be used as a meat tenderizer in the kitchen.
However, I do not recommend eating pineapple to supplement bromelain, because the sugar content of pineapple is still very high. I don’t need to say more about the disadvantages of consuming too much fructose.
Moreover, this enzyme mainly exists in the stems and core of pineapple, but very little in the pulp. Therefore, it is not cost-effective to supplement it by eating pineapple.
You can try it through supplements. If you want to improve digestion, you should take bromelain supplements with meals, but for other health conditions, you should take them on an empty stomach.
Shoulong has not tried this supplement yet, so I won’t recommend it to you. If you have tried it, you can share it in the comment area.
