children of patients with hepatolenticular degeneration really suffer from hepatolenticular degeneration?
Let us understand together ~
Hepatolenticular degeneration
Hepatolenticular degeneration is an autosomal recessive genetic disease. The chromosomes from the father and mother in the patient must carry the pathogenic gene at the same time before the patient may develop the disease. The distribution of patients in the
pedigree is often scattered, and continuous transmission is usually not seen. Sometimes there is even one patient in the entire pedigree. Its occurrence has nothing to do with gender, and the incidence of men and women is equal.
If a patient is married to a normal person who does not carry the pathogenic gene, the offspring will not get sick, and they are all normal people (heterozygous) who carry the pathogenic gene but do not get sick.
, such as the marriage of a patient and a normal person (heterozygous) who carries the pathogenic gene but does not have the disease, generally occurs in the marriage of close relatives, 1/2 offspring are onset, and 1/2 offspring are heterozygous.
If the patient is married to the patient, all offspring will be sick, but this kind of marriage is rare.
In close relatives marriage, the incidence rate among children is much higher than that in non-close relatives. This is because they come from a common ancestor and often share some common genes.
Carry out prenatal diagnosis for pregnant women at risk (referring to patients with hepatolenticular degeneration who have given birth to more than one child). If the fetus is diagnosed as having hepatolenticular degeneration, from the perspective of eugenics, the pregnancy can be terminated. The main measures to prevent this disease. The distribution of patients in the
pedigree is often scattered, and continuous transmission is usually not seen. Sometimes there is even one patient in the entire pedigree. Its occurrence has nothing to do with gender, and the incidence of men and women is equal.
