After four years of "five promotion and ten transfers" (5 egg-induced ejaculation and egg retrieval, 10 embryo transfers) in IVF, withstood the mental torture caused by multiple failed transplants, 39-year-old Yingying (pseudonym) finally successfully transplanted at Zhaoqing Xijiang Hospital and successfully gave birth to a baby girl recently.
Ma Wenmin (right) issued a "good pregnancy certificate" to patients
In fact, it is not uncommon for patients like Yingying to experience multiple transplant failures. Many people have this question: Why do some people successfully get pregnant by taking one test tube, while others fail repeatedly?
Ma Wenmin, an expert at the Guangdong Assisted Reproductive Technology Quality Management Center, deputy chairman of the Reproductive Medicine Branch of the Guangdong Medical Association, director of Zhaoqing Xijiang Hospital and head of the Reproductive Center, said that the average success rate of IVF in my country is about 50%, but whether IVF can be successful has a certain relationship with the number of assisted pregnancy. After multiple embryo transfers, the cumulative pregnancy rate of IVF will increase.
The existing data shows that the success rate of a single transplant is about 45%, the success rate of two IVF (in vitro fertilization) treatment is about 62%, the success rate of three IVF treatment is about 79%, and the success rate of four IVF treatments is about 90%.
Photo provided by the respondent
But why do some people "failure to repetitive transplants"? Ma Wenmin pointed out -
First of all, there is no unified definition of "repeated transplant failure", but now it is generally recognized that it means that more than 3 embryo transfers or cumulative transplants of more than 4 high-quality embryos have not been successfully conceived. The occurrence of repeated transplant failures in
may be caused by single factors or multiple factors in the joint impact. Some are unknown. At present, it is mainly considered from the two factors of embryo and maternal body:
embryo factors mainly include embryo genetic material defects, embryo hatching and poor development potential, and other related factors (clinical management and quality control, laboratory management and quality control), etc.
Maternal factors include immune factors, tendency to thrombosis, anatomical abnormalities, endometrium development and function abnormalities, frequent uterine contraction, endocrine factors, maternal psychological factors, etc.
So, how can we improve the success rate of embryo transfer?
Ma Wenmin pointed out that on the one hand, it is used to process the embryo, such as blastocyst culture . Patients who have transplanted high-scoring embryos multiple times can consider blastocyst culture to further screen embryos; in addition, it is to do genetic screening before embryo implantation, because embryo chromosomal aneuploidy is one of the important reasons for the failure of embryo transfer; on the other hand,
is to adjust the original ovulation induction plan to improve the quality and quantity of egg acquisition, and Its auxiliary measures: for example, the use of growth hormone , the use of weak androgens, lifestyle adjustment, etc.;
In addition, patients who fail to recurrence transplantation can also choose to undergo hysteroscopy. Sometimes, some abnormalities that cannot be displayed on the B-ultrasound can be found and targeted treatments can be performed, thereby increasing the chance of implantation ;
In addition, it can improve the receptivity of endometrium, regulate the local internal environment of the endometrium, and promote embryo implantation.
In short, "repeated failure of embryo transplantation is a headache for patients and doctors." Ma Wenmin admitted that doctors will vary from person to person, and try to improve the chance of success by adopting individual treatment plans.
[Reporter] Ou Xujiang
[Author] Ou Xujiang
Healthy life circle
