No matter you are a scientist,
or your mother,
will persuade you to strong2span more fruits and strong2span 4 fruits!
praise Fruits and vegetables can be supplemented with various nutrients is almost a common topic, but if 1span fruits and vegetables can prevent cancer, many friends _span4strong Some exaggerations.
Don’t say that fruits and vegetables can fight cancer and prevent cancer. It really comes from authoritative experts’ conclusions.
So how do small vegetables and fruits do it? Let's take a look at the ins and outs...
Intestinal microbes influence tumor progression
The tumor microenvironment is the "soil" on which tumors live.There are some innate immune cells in the tumor microenvironment, such as monocyte macrophages .
mononuclear macrophages will continue to differentiate, and this differentiation will either "become a fairy" or "become a demon", affecting the occurrence and progression of tumors.
Mononuclear macrophages differentiate into dendritic cells is called a "fairy road", becoming dendritic cells can promote and activate adaptive immunity to help the body fight tumors.
Mononuclear macrophages differentiate into macrophages can be called a "magic road", it may be to generate tumor-associated macrophages, which will promote the tumor-associated macrophages of proto-oncogene Express.
Here we cannot help but wonder: Is the differentiation of mononuclear macrophages random? Is there any way to control the differentiation of mononuclear macrophages and guide them on the "fairy road"?
Good news is here!
A recent study from the American Cancer Research Center found thatIn mouse experiments:
- mice colonized with gut microbes, and their tumor samples are enriched in dendritic cells _, these cells express . It is an anti-tumor gene .
- However, the tumor samples obtained from sterile mice contained a large number of macrophages _span_strong2 were protocarcinomas. And after using antibiotics in bacteria-containing mice, the phenomenon in sterile mice was reproduced.
This is not to tell us: gut microbes can control mononuclear macrophages to "become a fairy" or "become a demon"!
Intestinal microbes promote the efficacy of immunotherapy
The study also found that, Intestinal microbes can even increase the sensitivity of mice to immunotherapy and produce a stronger anti-tumor immune response, while immunotherapy basically does not work in sterile mice.
Further analysis shows that intestinal microbes can regulate the production of IFN-I in mononuclear macrophages. When a large amount of IFN-I is produced, natural killer cells will be recruited And gather in the tumor microenvironment, and the dendritic cells are continuously activated immediately thereafter.
In addition, the study also found a microbial metabolite-cyclic diadenylic acid (c-di-AMP), which can stimulate monocytes to produce IFN-I, and promote tree The dendritic cells penetrate into the tumor.
Fruits and vegetables have anti-cancer and anti-cancer effects
_strong dietary fiber is high in fiber and can effectively regulate the dietary fiber of 11span2 The composition of mononuclear macrophages in the microenvironment is , and the more you eat, the greater the number of Akkermansia muciniphila in the intestinal bacteria.
Akkermansia muciniphila is a resident of the human intestinal tract, accounting for 3~5% of the human microbial community. In recent years, in the research of cancer and tumor immunotherapy, it has been found that Akkermansia muciniphila is involved in the response of patients to PD-1 inhibitors, and this type of bacteria can also produce a large amount of cyclic diadenylic acid.
What’s more interesting is that even sterile mice implanted with Akkermansia muciniphila can have a stronger anti-cancer response. Some people even call this type of bacteria "promising bacteria".
There are carcinogenic factors that we cannot control, such as genetics, which we can control, and diet is a very important part of it. This time, did I suddenly feel that my mother was very willing to eat more fruits and vegetables every day?
Whether it is a healthy person or a patient who is unfortunately suffering from cancer, it is recommended eat more fruits and vegetables ! Take care of your intestinal flora, and it will take good care of you too!
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