grapefruit also known as "red grapefruit" and " grapefruit ". The fruit is red, juicy and has a good taste. It is a fruit that many people love. Grapefruit is rich in nutrients such as vitamins and has low calories. On average, each grapefruit contains only 82 kcal calories, making it one of the good fruits for weight loss.
But if you are taking some medicine and love grapefruit, you should pay attention, grapefruit and its products may affect the medicine you are taking .
① Metabolism of drugs
1 The furancoumarin derivative component in grapefruit can strongly inhibit the activity of P450 enzymes in the body (such as CYP3A4) . CYP3A4 is an important enzyme involved in the metabolism of various drugs.
After taking grapefruit juice , the CYP 3A4 enzyme will be irreversibly inhibited, resulting in a decrease in drug metabolism, increasing drug absorption, and increasing blood drug concentration. increases the effects and side effects of the drug simultaneously, causing direct damage to the human body .
②Absorption of drugs
Some drugs need to use "transport protein" to enter human cells and produce drug effects. Grapefruit contains , which inhibits the function of these transport proteins, which leads to insufficient absorption of drugs, and reduces the efficacy of .
How to avoid grapefruit affecting the effect of the drug?
. If you have the habit of eating grapefruit or grapefruit juice, please Consult the doctor or pharmacist about the relevant information about the drug and interactions .
2. Before taking the medicine, carefully read the drug instructions to see if grapefruit or its products will affect the medicine you are taking; and check the labels of juice or beverages seasoned with juice to see that they contain grapefruit ingredients.
3. In addition to the degree of effect of grapefruit on drugs, the dosage, drug interval, etc., there are also great differences in the degree of impact of different people, so the interaction results are also very different. cannot adjust the dosage of medicine at will.
Content source: Yaoyun.com WeChat public account
Organized and edited by: Journal of Integrated Traditional Chinese and Western Medicine
Correspondent: Qin Shasha Sun Lei Wang Jingjing Dong Wei
