At present, glucocorticoid is widely used in the treatment of primary thrombocytopenia in clinical practice. Hormones are first-line drugs. Commonly used hormones include prednisone, dexamethasone , prednisone, methylprednisolone , etc. Hormonal drugs can stimulate hematopoiesis, inhibit the formation of platelet antibodies in patients' bodies, and reduce the occurrence of bleeding. Although hormones work quickly, they also have inevitable side effects.
What are the side effects of hormone drugs?
1. There are general appearances of weight gain, lower limb swelling, and Cushing syndrome face and signs, acne , menstrual disorders in women, ischemia and necrosis of humeral and femoral heads, osteoporosis and fractures, muscle weakness , muscle atrophy, pancreatitis .
2. Mental symptoms appear, such as euphoria, anxiety, and directional disorders.
3, combined and concurrent infections, such as infections mainly consisting of fungi, tuberculosis , Staphylococcus, Proteobacterium , and various herpes virus .
4. Gastrointestinal reactions such as nausea and vomiting, as well as syndromes such as low fever and dizziness.
5, blood pressure and blood sugar may also increase.
TrombocytopeniaWhat changes will happen to the body after discontinuing hormones?
After the patient discontinued the hormone, the most direct change was that the platelet value dropped again. Patients who reduce medication too quickly or stop medication suddenly may experience a rebound and worsen. Because hormone drugs can affect the body's endocrine system, sudden stopping of medication may cause endocrine disorders, leading to worsening of the original symptoms and even serious complications.
In addition, after discontinuing the hormone medication, the patient may also develop glucocorticoid syndrome, manifested as dizziness, fatigue, loss of appetite, nausea, vomiting, decreased blood pressure, muscle or joint pain, headache, etc. In severe cases, metastatic disorders, shock, , etc.
Therefore, it is best for patients with thrombocytopenia to use hormone drugs for long-term treatment. Patients who use glucocorticoids continuously for a long time must not suddenly reduce the dosage or stop the medication suddenly. They should gradually reduce the dosage under the guidance of a doctor until the medication is stopped.
If the hormone drugs can achieve the best efficacy and minimize side effects, they need to use the medicine reasonably. During the process of stopping the drug, they can cooperate with traditional Chinese medicine treatment, which is more conducive to the stability of the disease and reduce recurrence.
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