Introduction: According to the relevant incomplete statistics of the 2021 International Diabetes Alliance data, it was learned that the population of people suffering from diabetes symptoms in the world can reach 537 million , which also accounts for about 12.5% of the total population. The difference between is equivalent to two out of every 10 people who have abnormal problems such as increased blood sugar.
metformin is the first recommended diagnostic and treatment guide for lowering glycemic drugs recognized by many countries and international organizations. It is mainly used in patients with type 2 diabetes and combined with the first-line basic drug . The condition of can bring about a certain stability within 2 to 3 weeks of taking it.
Mechanism for reducing blood sugar
Cucumber is the basic medicine for the treatment of diabetes, and it is also the first medicine. This medicine can directly act on the liver system to inhibit the production of sugar , reducing the body's output to liver glycogen .
can also inhibit sugar production, which means inhibit the transformation of other substances, such as egg white matter, fat, amino acid to glucose .
metformin can reduce the absorption of glucose by the gastrointestinal tract, reduces the body's blood sugar, and can also improve the ability of insulin to respond to external stimuli.
This drug can have good tolerance in people's bodies and safety. It can not only reduce blood sugar in people's bodies, but also significantly reduce blood sugar levels after meals, which is very suitable for all kinds of patients.
For example, diabetic patients with obesity, primary diabetes patients, with hypertension , etc.
metformin can reduce hemoglobin in people's body by about 2%. When used, it will not cause people to experience hypoglycemia. Therefore, compared with other hypoglycemia drugs, metformin will have a higher cost-effectiveness.
Can metformin be taken as a hypoglycemic drug for a long time?
In the above content, we mentioned that metformin is some drugs for the treatment of diabetes. For patients with no contraindications, metformin is the first choice drug for diabetic patients;
When other drugs are used in combination with metformin, they can not only bring about obvious hypoglycemic effects, but also reduce the use of other drugs. It is a full-process drug for the treatment of diabetes.
metformin can not only inhibit the intestinal absorption of glucose, but also effectively enhance peripheral tissues. Its sensitivity to insulin can not only reduce the output of liver glycogen , but also effectively improve the corresponding energy metabolism of peripheral tissues.
So if you analyze it through multiple mechanisms for lowering sugar, the drug can not only effectively reduce the fasting blood sugar level of , but also help you reduce the blood sugar level after meals of .
If the blood sugar level of newly diagnosed diabetic patients is not high, you can use metformin to lower blood sugar first. However, it should be noted that the effect of metformin to lower the glycemic is closely related to the dosage taken.
Diabetic patients need to take metformin and gradually increase the drug dose within 1 to 2 weeks. By the time 2000 mg is taken every day, this dose of metformin can maintain a very long-term hypoglycemic effect.
If necessary, patients with diabetes can increase the maximum dose per day, which is 2550 mg. According to relevant research, patients who take metformin for a long time can reduce the level of glycated hemoglobin to about 1% to 2%.
If you take metformin alone for more than three months and reach the best or maximum dose, but blood sugar still cannot be controlled to a reasonable range , you can take some other hypoglycemic drugs on the basis of metformin.
Although metformin can bring a very obvious hypoglycemic effect, many patients still cannot tolerate the adverse reactions brought by metformin, , and a few patients are likely to stop taking the medication for a long time due to adverse reactions.
Speaking of the adverse reactions caused by drugs for lowering sugar , many people think it is hypoglycemia, but metformin rarely has hypoglycemia when taken alone.
The main adverse reaction is intestinal reaction , such as gastrointestinal reactions in diarrhea, abdominal pain, nausea, vomiting, loss of appetite, etc.
Generally, these common adverse reactions will occur. are born in the first 10 weeks of taking the medication. As the medication is taken, the corresponding symptoms of the patient will be gradually tolerated, and will gradually relieve the disappearance.
For patients who cannot tolerate it, it is not a solution to take ordinary tablets. They can start from the minimum dose and take them in batches. This can reduce the adverse reactions caused by the drug and also reduce adverse reactions in the gastrointestinal tract.
Take metformin to reduce the body. The absorption of vitamin B12 will easily lead to megaly red blood cell anemia , , so patients who take this drug for a long time need to monitor vitamin B12 regularly, and should also supplement reasonably.
Can the kidneys afford it?
As for the long-term use of metformin, will actually have different answers to the question of whether will damage the kidneys.
Metformin itself will not damage liver and kidney tissue, but during the time of taking metformin, liver and kidney function needs to be tested regularly.
is not because metformin itself has renal toxicity, but that metformin will affect the removal of certain drugs in the body and cause drug accumulation, thereby damaging the kidneys and liver . Therefore, taking metformin for a long time is affordable for normal people, but for those with renal insufficiency, there are certain dangers.
So if people with incomplete kidney function, can they take metformin lowering glycemic drugs?
For those with renal insufficiency, they must use metformin with caution. It is not because metformin itself has renal toxicity, but is that patients with renal incomplete renal function may easily cause renal excretion disorders.
Under this problem, it will affect the removal of metformin in the body, causing the accumulation of drugs, which will easily increase the overdose of drugs, which will bring the risk of poisoning.
For patients with renal insufficiency, when applying metformin, different experts from also have different suggestions. You can consult the attending doctor based on your personal situation.
Take metformin every day, take a few minutes to figure out these 3 precautions, it is very important to
Pay attention to the medication time
When using metformin, be sure to pay attention to the time . The best time to take this medicine is to take with the meal. You can take the first meal with the meal.
avoid hypoglycemia caused by not eating after taking medication , which not only cannot control blood sugar, but also can easily cause physical damage.
Pay attention to supplementing vitamin B12
We mentioned in the above content that metformin can easily interfere with the absorption of vitamin B12, so when we take metformin, must pay attention to supplementing vitamin B12 more, which can be supplemented through food.
. Please avoid alcohol during medication
. Wine is a type of carbohydrate . You need to avoid alcohol during taking metformin. After drinking alcohol, it will easily inhibit the output of glucose in the liver and it will easily lead to hypoglycemia problems. Therefore, you must avoid alcohol during taking metformin.
Conclusion: Diabetes is like hypertension. It is a difficult disease to treat and can easily make people feel terrible. If you are a diabetic, you must take reasonable measures to stabilize blood sugar by taking drugs and life intervention to avoid falling into the troubles caused by diabetes to your health.
