Hubei University Scientific research has also spread good news
Recently, the key special project of
" Synthetic Biology " led by Hu University
"Industrial Strain Reprogramming Optimization and Application" project
officially approved project
This project is the third national key research and development plan approved by our school in the fields of "synthetic Biology"
and "green biomanufacturing"
project
is also another achievement in our school's insistence on carrying out organized scientific and technological research around the major national strategic needs
About the National Key R&D Plan Special
National Key R&D Plan Special
National Key R&D Plan Special tweets mainly target major, core and key scientific and technological issues in national economic and social development, organize the advantages of industry, academia and research to work together, propose overall solutions, and provide continuous support and guidance for the main areas of national economic and social development.
"Reprogramming and Optimization and Application of Industrial Strains" project
This project is led by our school's School of Life Sciences , the State Key Laboratory of Biocatalytic and Enzyme Engineering jointly established by the province and the Ministry of Education Professor Yang Shihui , and was jointly participated by Hubei University, Dalian University of Technology , Tianjin University of Science and Technology , Zhejiang University of Technology , Jiangnan University , Beijing University of Technology , Beijing University of Technology , Beijing University of Technology , Beijing University of Technology , 26 units participated, with a project fund of 18 million yuan. The
project aims at bottleneck problems such as few genetic tools, poor stability, and difficulty in real-time detection in situ. Combined with the advantages of model and non-model industrial strains, relying on model strains with rich data, advanced models and diverse editing tools, the application of target pathways in important models and non-model industrial strains will be clarified through the application of target pathways in important models and non-model industrial strains, and the molecular mechanism restricting the efficiency of genetic transformation and genome editing of industrial strains, and the adaptation of target pathways to the chassis cells, establish a new theoretical and technical system with excellent industrial strain design and reprogramming to achieve industrial production of major products.
Professor Yang Shihui's team
Professor Yang Shihui's team has been engaged in research in the fields of microbial metabolism engineering, systems and synthetic biology and green biomanufacturing. Taking Z. motile as the research object, a biological component mining and quantitative identification system based on omics data and an efficient genome editing system integrating internal and exogenous CRISPR-Cas systems were established; cellulose ethanol, isobutanol and PHB high-yield recombinant strains were constructed, and ethanol continuous fermentation and PHB cogeneration were achieved.
At the same time, it has cooperated with many companies including listed companies for a long time to transform industrial strains with many excellent characteristics using systems and synthetic biology technology, and promote the industrialization of bulk alkyd products with a trillion-dollar market using anaerobic fermentation of non-grain raw materials such as straw, and help achieve the goal of bioeconomic and "dual carbon" to achieve.
Development Archives
Since its establishment in October 2018, with the strong support of the school, it has targeted the forefront of international research on biocatalytic and enzyme engineering and major key national technology needs, and carried out basic and applied basic research in the field of biocatalytic and enzyme engineering to meet the major needs of the development of the country's biological industry, and contributed to the construction and development of the school's " Double First-Class ".
Laboratory has introduced and trained 9 talents at the national level and ministries and commissions, 40 talents at various provincial and municipal levels, and has been approved for 45 in Hubei Province Innovation Team; it has taken the lead in undertaking 43 in special projects of the National Key R&D Plan, 7 projects, and 448 sub-projects , and has been approved for 481 in national projects such as the National Natural Science Foundation and more than 4,120 in horizontal projects, with a total scientific research fund of 00 million yuan.
in Nature, Cell, Nature Catalysis, Nature Metabolism, Nature Reviews Chemistry, Nucleic Acids Research, Circulation and Nature International journals such as Communication have published more than 4480 papers in , and have won invention patents in 10 , domestic authorized invention patents in 120 , and received 46 in Hubei Science and Technology Awards in ; have created cryo-electron microscope platform, protein science, biological imaging, bioinformatics platform, and have built leading structural biology research platform in central China.
(Source: Hubei University Official WeChat)
