https://www.nature.com/articles/s41586-022-04924-6
Researchers such as Stefano Piccolo from the University of Padua in Italy discovered that the key factor of mechanical force signaling-YAP/TAZ plays a key role in cellular aging (1, 2).
Researchers found in mouse models that the YAP/TAZ activity of in stromal cells (fibroblasts, etc.) of skin and other tissues decreased with aging; young skin stromal cells showed an aging phenotype after knocking down YAP/TAZ. ; Overexpression of YAP/TAZ in aged stromal cells reverses aging-related changes (2).
YAP/TAZ is less active in stromal cells of aging tissues; overexpression of YAP/TAZ can reverse aging-related phenotypes (2)
Further analyzing its mechanism, researchers found that YAP/TAZ inhibits the cGAS–STING signaling pathway, which is key to innate immunity. exerts an anti-aging effect; the reason for inhibiting cGAS–STING signaling may be that YAP/TAZ protects the integrity of the cell nucleus by directly regulating key proteins of the nuclear lamina (2).
This work was published in nature on June 29; researchers believe that this work provides a model for potential spatiotemporal analysis of aging at the cellular level of organisms, and provides new ideas for alleviating age-related diseases and healthy aging (2).
Comment(s):
As mentioned in the article, the selectivity of cell senescence, that is, why and how stromal cells experience a decrease in YAP/TAZ signaling and the aging phenotype requires further in-depth study (2).
In addition, these data also seem to indicate that moderate massage has the potential to have a positive effect on delaying aging.
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References:
1. T. Panciera, L. Azzolin, M. Cordenonsi, S. PicColo, MeChanobiology OF YAP and TA TA TA TA TA TA TA TA TA TA TA Z in Physiology and Disease . Nat. Rev. Mol. Cell Biol. 18, 758–770 (2017).2. H. L. Sladitschek-Martens et al., YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS–STING. Nature, 1–9 ( 2022).
Original link:
https://www.nature.com/articles/s41586-022-04924-6
