Author: Guangdong Pharmacy Society, Fifth Affiliated Hospital of Sun Yat-sen University, Chief Pharmacist Chen Qiufeng
Breast Cancer Prevention and Treatment Promotion Day —October 18, 2022
aims to popularize breast disease knowledge and increase public awareness of breast cancer . How scary is breast cancer? Breast cancer is known as the number one health killer for women, and its incidence ranks first in the incidence of malignant tumors in women, seriously threatening women's lives and health.
In breast cancer, HR (+) (hormone receptor positive) HER2 (-) (human epidermal receptor factor receptor 2 negative) is the most common molecular subtype. For breast cancer patients with such molecular subtypes, endocrine therapy is the main treatment plan. In recent years, clinical research and practice have proved that the addition of cell cycle-dependent kinase (CKD4/6) inhibitors can effectively improve the effect of endocrine therapy, which has brought new hope to patients with advanced HR (+) HER2 (-).
CDK4/6 inhibitor mechanism
interferes with the cell cycle and inhibits tumor proliferation
cell cycle can be divided into four stages: G1 phase, S phase, G2 phase and M phase.
In cancer cells, CDK4/6 binds to cyclin (CyclinD), regulating the binding of cells from G1 to S phase, promoting the value-added of cancer cells. CDK4/6 inhibitors can effectively prevent the progression of the G1 to S phases of the cell cycle, prevent the division of cancer cells, and thus inhibit the proliferation of tumors.
At present, all CDK4/6 inhibitors that can be used in China are oral preparations, and there are the following three types:
, piperaceli
, abeceli html
3, Dalcili
Advantages:
, greatly improving the prognosis of patients with advanced breast cancer in HR (+) and HER2 (-) stages, and effectively prolonging the patient's survival.
. Side effects are less hemotoxic than traditional chemotherapy, and adverse reactions are easier to manage.
, convenient oral administration. domestically approved indications:
Perbosili | , combined with endocrine therapy Drugs for locally advanced or metastatic breast cancer of HR (+) HER2 (-) |
abecili | , combined with endocrine therapy drugs for HR (+) HER2 (-) Early stage high-risk recurrent breast cancer; , locally advanced or metastatic breast cancer combined with endocrine therapy HR (+) HER2 (-) |
Dalcili htt ml5 | , combined with endocrine therapeutic drugs for relapse or progress of HR (+) HER2 (-) locally advanced or metastatic breast cancer |
Main adverse reactions:
■ Neutrophilopenia;
■ Diarrhea;
■ QT interval prolongation;
■ Hepatotoxicity;
■ Venous thromboembolism;
■ Interstitial lung disease;
Tips for taking medication:
. Do not crush, chew or divide the tablets when taking medication;
. Avoid combining the use of strong CYP3A4 inducers/inhibitors, as combinations will reduce the effectiveness of CDK4/6 inhibitors/increase the risk of increasing toxicity.
Early prevention, early detection, early treatment” is an important concept of breast cancer prevention and treatment. Below, we will share with you some prevention knowledge about breast cancer:
① Early detection, early treatment, regular screening.
② Avoid getting married and having children too late, and try to breastfeed after giving birth.
③ Control your weight and eat less foods with high fat.
④ Avoid long-term use of contraceptives and reduce estrogen intake.
⑤ Enhance physical exercise and maintain a good lifestyle.
Reviewer: Deputy Director Pharmacist, Fifth Affiliated Hospital of Sun Yat-sen University Guo Xinming
or above are original works of volunteers of the "Drug Safety Cooperation Alliance". If reprinted, please indicate the author and source!
[Yaoduan Charity] is a public welfare organization jointly initiated and established by the China Over-the-counter Drug Association, Chinese Pharmaceutical Society , Chinese Medical Association, etc. - PSM Yaoduan Charity (public account: PSM China), which brings resources to gather strength and promotes public drug safety.
regimen Latest News
-
In our body, the liver is a big model worker, and it depends on it to work hard. Did you know that it handles more than 500 kinds of biochemical reactions every day, and can be said to be a giant chemical factory for the human body. But it will not be tired or painful, nor will i - DayDayNews
-
If the lungs are hot or dry, the skin will be dry. Therefore, when autumn comes, the skin at the end of the limbs must be dry and cracked. Therefore, to ensure that the skin is tender and smooth, skin care products alone are not enough, and protecting the lungs is the key. - DayDayNews
-
Frost is approaching, remember to eat "2 black and 3 red" often to nourish and nourish people. Smooth the seasons alternate between frost is the last solar term in autumn. During this solar term, the temperature will drop rapidly at night. After the cold dew, the dew on the groun - DayDayNews
-
Cervical spondylosis refers to a clinical syndrome that causes cervical vertebrae bone hyperplasia, or dissection of the intervertebral disc, thickening of ligaments, and stimulation or compression of the cervical spinal cord, cervical nerves, and blood vessels, causing a series - DayDayNews
-
In most people's impression, what causes obesity is the calories of the diet. But in fact, it is not only the calories that can induce obesity and affect the body in life. Even the insignificant seasonings have a huge impact on the body. Eating them properly can speed up fat burn - DayDayNews
-
Tea and coffee can be said to be the best-selling drinks in the world. When you feel sleepy, whether it is to make a cup of tea or make a cup of coffee, it can achieve the effect of reminding and refreshing. If you are a tea or coffee lover, would you be confused: Does drinking t - DayDayNews
-
Many people assume that this is a sign of age. In fact, these are a series of symptoms of menopause. Xiao Qing shares 5 dietary methods with you and talks about how to spend menopause smoothly. - DayDayNews
-
When you wake up in the morning, you should be lazy for 3 minutes, then take a deep breath, yawn, and stretch. According to medical observation, cerebral strokes often occur at night, the most dangerous moment is the moment of waking up, and the early morning is the peak time whe - DayDayNews
-
Qianjiang Evening News·Hours News Correspondent Shen Jie Xu Youjia Uncle Shen from Anhui is 62 years old. Shortly after retirement, he opened a small restaurant with several friends. From outsiders' perspective, he has a successful career and a happy family. He has recently been - DayDayNews
-
Q: How are you preparing to overcome the disease? Answer: I am not going to fight against illness. I am not ready to defeat anyone, and I don’t know much about certain diseases. So I'm not going to fight with him. Q: Isn’t disease the enemy of health? Answer: Disease is never an - DayDayNews
Site article recommendation
-
The election headquarters of Zhang Shanzheng's South District will be held in Zhongli on the evening of the 8th. Taoyuan South District is the base camp of the Kuomintang. Zhang Shanzheng's election chairman Lu Yuling is in Pingzhen, South District. Qiu Yisheng's election preside - DayDayNews
-
The Kaohsiung mayoral by-election shows a three-legged situation. The Kuomintang is fully supporting the candidate Li Meizhen. Members from all over the country also form groups to go south to Kaohsiung to accompany the streets and vote. The Legislative Yuan party group will coop - DayDayNews
-
According to Taiwan's China Times Electronic News, the 2020 "general election" has entered the last 21 days. Regarding the election situation, senior media person Qiu Mingyu pointed out that the Kuomintang has been saying that Han Kuo-yu and Tsai Ing-wen's polls are only 5%, abou - DayDayNews
-
During the event, they compiled and distributed materials such as "When you know and understand the Twenty National Congress Report" and "50 Questions for the Twenty National Congress Report", and adopted the method of "concentrated learning, personal self-study, and discussion t - DayDayNews
-
Students' growth education comes from many aspects, such as parents, teachers, classmates and friends, which will influence students subtly and have a profound impact on students' three views and thinking. However, if parents' three views are not correct and misbehave, then there - DayDayNews
-
People in recent South Korea revealed that the Party Central Committee contacted the municipal government's staff last week and expressed their hope to invite Han Kuo-yu to take over as the designated Central Standing Committee member. Since the Kaohsiung resignation case is in f - DayDayNews