Alcohol liver disease is a relatively common disease, mainly due to liver disease caused by excessive drinking in people's daily life.
Generally speaking, excessive drinking will increase the burden on our liver and will also cause liver cell contraction.
Alcohol liver disease needs to be treated in time, otherwise it will easily have a great impact on physical health.
Why do you get alcoholic liver disease?
Alcoholic liver disease (ALD) is a liver disease caused by long-term large-scale alcohol consumption. It is clinically divided into mild alcoholic liver disease , alcoholic fatty liver , alcoholic hepatitis , alcoholic liver fiber Five stages including chemical and alcoholic cirrhosis .
The main ingredient of alcohol is ethanol, of which more than 90% are metabolized in the liver. It is roughly metabolized to acetaldehyde from the liver, and acetaldehyde is further metabolized to acetic acid .
Alcohol liver disease occurs as the direct or indirect damage to liver cells by ethanol and its metabolites. It may involve the following mechanisms:
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Acetaldehyde is a highly reactive molecule that can bind to protein to form acetaldehyde protein Compounds affect normal physiology and damage hepatocytes.
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acetaldehyde sensitizes hepatocytes to tumor necrosis factor -mediated killing and sensitization. It eventually leads to hepatocyte death.
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ethanol metabolism oxygen consumption, increasing the oxygen consumption of liver and liver lobular oxygen gradient, It causes hypoxia in the central lobular area and damages liver tissue.
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ethanol metabolism consumption causes intrahepatic metabolic disorders, which may be one of the causes of hyperlipidemia and fatty liver.
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The blood concentration of ethanol in patients with long-term large-scale alcohol consumption is too high, and intrahepatic vasoconstriction and hemodynamic disorders are caused by intrahepatic vasoconstriction and hemodynamic disorders. The reduction of oxygen supply, coupled with the increase in metabolic oxygen consumption of ethanol, further aggravates hypoxemia , leading to deterioration of liver function.
What are the high-risk factors for alcoholic liver disease?
Regional epidemiological survey results show that the proportion of drinking population in my country is showing an upward trend.
21st century, Epidemiological Survey of ALD in some provinces in my country showed that the prevalence of ALD was 0.50%-8.55%; among them, the prevalence of ALD among people aged 40-49 was the highest, reaching 11.6%.
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htm As the amount of alcohol consumed or drinking life increases, the risk of liver damage to also increases accordingly. A meta-analysis of found that drinking 12~24g of alcohol per day, cirrhosis and increased risk of death.
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Drinking methods
- html l1Drinking on an empty stomach is more likely to cause liver damage than drinking during meals;
- Drinking on a daily basis is more likely to cause serious alcoholic liver damage than occasional drinking.
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gender
women are more sensitive to alcohol-mediated hepatotoxicity than men, which may be related to estrogen and gastric ethanol dehydrogenase levels, and are more likely to develop severe alcoholic hepatitis and cirrhosis.
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malnutrition
html l1 Long-term drinkers have increased their demand for trace elements such as choline , vitamins A, B, E, folic acid and selenium. Because long-term drinkers cannot maintain a normal dietary structure, they are often accompanied by other nutritional conditions. Material deficiency.
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obese
Obesity or overweight can increase the risk of progression of alcoholic liver disease.
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combined hepatitis virus infection
drinking alcohol on the basis of hepatitis virus infection, or hepatitis B or C virus infection on the basis of alcoholic liver disease, can accelerate the development of liver disease.
The risk of alcoholic liver disease will increase with the increase in the amount and duration of alcohol intake, so everyone must try to drink as little as possible.
