Aspirin, also known as acetylsalicylic acid , is a common antipyretic and analgesic drug. Its main pharmacological effects are antipyretic, analgesic and anti-inflammatory and anti-rheumatic.
was first used as an antipyretic and analgesic. Now it is mainly used as an anti-platelet aggregation drug to prevent cerebrovascular diseases. For patients who have already developed cardiovascular and cerebrovascular diseases, such as cerebral infarction and myocardial infarction, oral aspirin can effectively prevent the recurrence of cardiovascular and cerebrovascular diseases.
There are usually two types of aspirin, divided into aspirin and aspirin. Its main ingredients are acetylsalicylic acid. It can prevent heart disease, stroke and thrombus , and reduce the risk of death from myocardial infarction. It can also prevent platelets from aggregating in damaged blood vessels and has an anticoagulant effect.
Aspirin is a non-steroidal anti-inflammatory drug. In recent years, it has been widely used as an anticoagulant to prevent cardiovascular and cerebrovascular embolism.
What is the mechanism of aspirin analgesia?
Aspirin is usually a white crystal or crystalline powder that is slightly soluble in water and has a relatively good effect in relieving mild or moderate pain. There may be two analgesic mechanisms:
1. Inhibit the release of mechanical and chemical sensitive substances that stimulate pain, such as prostaglandin, bradykinin , histamine and other pain-causing factors. (To) reduce the occurrence of pain-causing factors and further achieve the analgesic effect, it is a peripheral analgesic.
2. Regulate the brain central nervous system , act on the hypothalamus, affect pancreatic release, and serve the purpose of analgesia. It is commonly used to relieve neuralgia , headache, muscle pain and other symptoms.
Aspirin also has an antipyretic effect and is suitable for relieving colds, fever and other symptoms. Its mechanism of action is to regulate the temperature regulation center of the hypothalamus, causing peripheral blood vessel expansion, promoting blood circulation, increasing skin sweating, and achieving heat dissipation and detoxification. hot purpose.
What diseases can aspirin be used to treat?
. Pain caused by disease
Aspirin has antipyretic and analgesic effects and is often used for fever caused by the common cold or influenza . When unexplained headaches, toothache, neuralgia, joint pain and dysmenorrhea occur, they can also be relieved by taking aspirin.
, Rheumatic fever
Aspirin is also often used in rheumatic fever. It can relieve fever in time, reduce inflammation, and promote the gradual improvement of joint symptoms. It can also reduce erythrocyte sedimentation rate , but it cannot fundamentally solve the problem of rheumatic fever.
When obvious myocarditis occurs, first take adrenocortical hormone . After the symptoms are controlled, adrenocortical hormone should be stopped and aspirin treatment should be added. This can avoid rebound caused by sudden stop of hormone drug .
, Rheumatoid arthritis
Patients with rheumatoid arthritis can also take aspirin, which can relieve redness, swelling, heat and pain and improve the efficacy of treatment. In addition, it can also assist in the treatment of osteoarthritis, ankylosing spondylitis , and musculoskeletal pain caused by other factors.
4. Prevention of heart disease
In recent years, it has been discovered that aspirin can inhibit platelet aggregation and prevent thrombosis. It is often used to prevent temporary cerebral ischemia and myocardial infarction.
In addition, arteriovenous fistula, artificial heart valve and atrial fibrillation also need to take aspirin to prevent thrombosis. In addition, aspirin can also treat unstable angina pectoris .
If I insist on taking one aspirin a day, will my body be able to bear it? See the doctor's answer
Aspirin can resist platelet aggregation. If there is a plaque rupture in the blood vessel, taking aspirin can reduce platelet aggregation, which can reduce the incidence of blood clots.
Platelets in the blood have a lifespan. Generally, the lifespan of platelets is 7 days, which means that there are new platelets every day. In order to better inhibit platelet aggregation, you need to take an aspirin every day to inhibit the aggregation of new platelets.
For people with arteriosclerosis and thrombosis, plaque rupture will activate the platelet function . A large number of platelets will aggregate together to stop bleeding. If you insist on taking an aspirin every day, the anticoagulant of platelets in the blood will be activated. function, thus reducing the risk of myocardial infarction and cerebral infarction .
In short, aspirin can prevent blood clots and reduce the risk of cardiovascular disease, but it also has side effects, making the body prone to bleeding and damaging the digestive tract.
If you take this drug for a long time, it will increase the incidence of diseases, which is very detrimental to your health. As early as 2014, Japan conducted a study that found that taking a small dose of this drug every day did not work for people with cardiovascular disease.
Aspirin is a double-edged sword. It can not only act directly on gastric mucosa and promote the release of leukotrienes and other cytotoxic substances, but it can also damage the mucosal barrier. As a preventive drug, aspirin's effect is not obvious, but the dangers it brings still exist:
① Aspirin can cause direct irritation to the gastric mucosa, so it can also commonly cause gastrointestinal reactions, such as nausea and vomiting. Or abdominal discomfort or pain occurs.
② has central nervous system side effects, such as causing tinnitus or hearing loss, headache or dizziness.
③ There will be allergic reactions, such as rash or itching, and it may also induce asthma or cause urticaria , etc.
④ Aspirin will cause certain damage to liver and kidney function. Generally, it will cause damage when used in large doses for a long time, so you must pay attention when using the drug.
Who is not suitable for taking aspirin?
For patients with the following conditions, it is not suitable to take aspirin for treatment, otherwise adverse reactions such as gastrointestinal bleeding and allergies will easily occur, which will endanger the patient's health, as follows:
. Aspirin or other salicylates Allergy to salt or any other ingredient in the medicine.
. Acute gastrointestinal ulcer, or the patient has bleeding constitution and history of severe bleeding.
, Salicylic acid or a history of asthma caused by substances containing salicylic acid and non-steroidal anti-inflammatory drugs.
4, coupled with severe liver and kidney failure.
5. Concurrent with severe heart failure .
6. In addition, it is not suitable to take aspirin in the last 3 months of pregnancy.
How to take aspirin correctly?
. Check your body in time
If you want to take this medicine, you should check your body before taking the medicine to see if there are certain diseases in your body, such as bleeding and gastrointestinal ulcers.
If you find this disease, try to avoid taking it, because taking aspirin regularly can easily damage the gastric mucosa and cause stomach diseases.
. Pay attention to the medication time
Generally speaking, when taking aspirin, it is usually once a day, and the peak period of cardiovascular disease is in the early morning. After taking this drug, it takes 3 to 4 hours to have the best effect.
Therefore, when taking medicine, try to take it before falling asleep to avoid platelet aggregation and help prevent cardiovascular disease.
. Correct dosage
When taking medicine, you should take it according to the guidance of your doctor. Overdosing will cause side effects to the body and easily cause bleeding.
