Vitamin B1 combines with pyrophosphate in the body to form a cocarboxylase, which participates in the oxidative decarboxylation reaction of sugar metabolism of pyruvate and α-ketoglutarate in the sugar metabolism of . Essential vitamins for the prevention and treatment of beriberi and diabetes, polyneuritis, myocarditis, pediatric enuresis, polio sequelae, lack of appetite, indigestion, hyperthyroidism, Adjuvant treatment of various diseases such as systemic infection and high fever, and helps to improve hearing impairment caused by gentamicin and streptomycin.
When vitamin B1 is lacking, oxidation in the body is blocked to form pyruvate, lactic acid accumulates , and affect the body's energy supply. The symptoms are mainly manifested in the nervous system and cardiovascular system. Multiple peripheral neuritis in which both sensory nerves and motor nerves are affected occurs. It is manifested as paresthesia, neuralgia , limb weakness, muscle aches and atrophy. In cardiovascular aspect, due to the increase of pyruvate and lactic acid in the blood, the arterioles dilate, diastolic blood pressure decreases, and myocardial metabolism is imbalanced, so it is prone to palpitations, shortness of breath, chest tightness, peripheral tissue edema, liver and lung congestion, and heart Hypertrophy and other symptoms of cardiac insufficiency. The digestive tract is manifested as a decrease in appetite, which can lead to weakness and weight loss.
Vitamin B2 is a component of the flavinase prosthetic group in the body, which can participate in the metabolism of sugar, fat, protein and nucleic acid, promote the growth and development of the body, such as the normal growth of nails, skin and hair, and affect the body's absorption of iron , To maintain normal visual function, suitable for the prevention and treatment of vitamin B2 deficiency and the adjuvant treatment of migraine.
When vitamin B2 is deficient, it affects the body's biological oxidation, and its lesions are mostly inflammation of the mouth, eyes and external genitals, such as angular cheilitis, glossitis, cheilitis span6span, conjunctivitis, blepharitis, seborrheic dermatitis, scrotalitis, etc.
Vitamin B6 interacts with ATP in the body to produce physiologically active pyridoxal phosphate and pyridoxine phosphate, which are aminotransferases, decarboxylase and digestive enzymes of certain amino acids 's coenzyme It participates in many metabolic processes, such as the production of the inhibitory neurotransmitter γ-aminobutyric acid in the brain, the conversion of tryptophan to niacin, etc. It can also stimulate the growth of white blood cells and hemoglobin. It is suitable for the prevention and treatment of peripheral neuritis, insomnia and restlessness caused by large or long-term use of isoniazid, hydralazine, etc., and reduces nausea, vomiting or pregnancy vomiting caused by anticancer drugs and radiotherapy. It may also help In leukopenia.
When vitamin B6 is lacking, the common manifestations are seborrheic dermatitis, chapped lips, insomnia, etc. It can also lead to multiple peripheral neuropathy, manifested as tingling, numbness, loss of sensation in arms and legs, and feet Burning sensation in the body or hands, etc.
Vitamin B12 is an important coenzyme for cell synthesis of nucleotide . It is involved in methyl conversion and folic acid metabolism . The lack of it can lead to folic acid deficiency , which leads to DNA synthesis obstacles and affects the development of red blood cells. And maturity.In addition, lack of vitamin B12 can also lead to increased excretion of methylmalonic acid and abnormal fatty acid metabolism, which is likely to be one of the causes of neurological diseases. It can be used to treat pernicious anemia. It can also be used in combination with folic acid to treat various megaloblastic anemia, anemia caused by antifolates. It can also be used for multiple peripheral neuritis, neuralgia, neuroatrophy and other neurological diseases And liver diseases such as hepatitis and cirrhosis.
Folic acid is a B vitamin composed of pteridine, p-aminobenzoic acid and glutamic acid. It is a substance necessary for cell growth and division, and can participate in nucleic acid and The synthesis of amino acids, together with vitamin B12, promotes the proliferation and maturation of red blood cells. It is used for various megaloblastic anemias and pernicious anemias. It can also be used as a preventive medicine for pregnant and lactating women to prevent fetal neural tube development defects.
In the absence of vitamin B12 and folic acid, anemia symptoms such as paleness, decreased endurance, fatigue, dizziness, dizziness, and palpitations may occur. A small number of patients may have mild jaundice. In severe cases, pancytopenia and repeated infections may occur. And bleeding, it can also cause oral mucosal atrophy, tongue pain, nausea, abdominal distension, diarrhea, constipation, loss of appetite, indigestion and other digestive system manifestations, as well as limb numbness, sensory disturbance, unsteady gait, taste Nervous system manifestations and psychiatric symptoms such as decreased sense of smell, darkening, and decreased vision. The difference is that people with vitamin B12 deficiency have depression, insomnia, delirium, hallucinations, delusions, mental confusion, and decreased memory. Those with folic acid deficiency have irritability. , Delusions and other mental symptoms. In addition, folic acid and vitamin B12 deficiency can also lead to hyperhomocysteinemia, which is a risk factor for stroke.
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