The last month of 2022 is destined to be filled with extraordinary things.
A few weeks ago, students and workers living abroad were still worried about whether they would continue to advocate celebrating the New Year in situ this year. However, with the issuance of the "New Ten Measures" on December 7, the country has fully relaxed epidemic prevention and control, health codes and green codes in public places have been cancelled, and people have gradually returned to the free life before 2019.
Omicron has become a national immunity competition. People without yang compete with each other to see who can survive longer, and people with yang battle with each other over who can recover faster. In the post-epidemic era, having a stronger immunity has become a new fashion among trendsetters, and canned yellow peaches have become a new "epidemic prevention tip", which is rich in vitamin C and trace elements (such as zinc) and is even called a "panacea".
(Picture source: Internet)
Is this "really effective" or "too much touted"?
In this regard, scientists in the United States designed a randomized controlled trial to explore whether vitamin C and zinc supplements can bring benefits to the routine treatment of COVID-19 patients.
This trial recruited a total of 214 COVID-19 patients. All patients were randomly divided into 4 groups, receiving routine care, taking vitamin C (8000mg), taking zinc gluconate (50mg), or taking vitamin C + zinc gluconate at the same time. They then compared the severity and duration of the patients' symptoms.
Surprisingly, clinical experiments have proven that compared with routine care for COVID-19 patients, adding vitamin C + zinc has no significant therapeutic effect.
Number of days required for 50% symptom reduction in patients in different treatment groups
Oh no! The yellow peach canned in my hand suddenly lost its flavor. Don’t be disappointed yet, canned yellow peaches have their own uses.
Recently, a study titled Zinc and vitamin C intake increases spike and neutralizing antibody production following SARS-CoV-2 infection published in Clin Transl Med showed that after COVID-19 infection, taking vitamin C + zinc at the same time can increase the level of neutralizing antibodies as much as possible in patients with "Yangkang" and reduce the chance of re-infection and reinfection. It seems that eating canned yellow peaches is still beneficial.
A research team from National University of Singapore conducted this study. The main purpose was to observe the impact of zinc and vitamin C on the production of neutralizing antibodies in the human body after COVID-19 infection. The study cohort consisted of 422 men, 68 of whom took zinc (80mg zinc sulfate) + vitamin C (500mg), 81 took vitamin C (500mg), 67 took hydroxychloroquine (200mg), 99 took ivermectin (12mg), and 107 took povidone-iodine throat spray (270ug). The study lasted 42 days to reduce SARS-CoV-2 infection.
Surprisingly, the anti-SARS-CoV-2 immunoglobulin G (IgG) levels in the patients were tested on day 42. found that compared with other intervention groups, the IgG levels in the zinc + vitamin C group were significantly higher . The test of neutralizing antibodies found that the conversion rate of positive neutralizing antibodies in the zinc + vitamin C group was as high as nearly 50%, which is far better than the antiviral drugs hydroxychloroquine (30.8%), ivermectin (20%) and povidone iodine (9.8%)!
Comparison of SARS-CoV-2-specific antibodies between intervention groups
The research team emphasized: "After asymptomatic infection, more than 50% of individuals had suboptimal neutralizing antibody production. Compared with other interventions, those who received zinc + vitamins People with C were later found to produce a greater antibody response. "This means that the "Yangkang" who were infected during the first wave of can enhance their body antibody levels by appropriately supplementing vitamin C + zinc to protect themselves from secondary infection with when facing the subsequent peak of infection.
So, in addition to the common vitamin C and zinc, are there any other supplements that can be used to recover from COVID-19?
Coincidentally, Italy conducted a nationwide LINCOLN survey. 1,390 COVID-19 patients were evenly divided into two groups and received 30 days of treatment. The first group received L-arginine 1.66g and 500mg vitamin C every day, and the second group received a multivitamin combination treatment. The Borg classification ratio scale was then used to score the perception of sequelae of COVID-19 (higher scores represent stronger perceptions of sequelae).Unexpectedly, the combination of L-arginine and vitamin C significantly reduced the sequelae of COVID-19 compared with patients who received a multivitamin combination.
Another study published in Scientific Reports showed that supplementing vitamin D was significantly related to reducing the risk of new coronavirus infection, and could also reduce the new coronavirus mortality rate. They found that supplementing vitamin D2 and vitamin D3 were associated with a 28% and 20% reduction in the incidence of COVID-19, respectively, and vitamin D2 and vitamin D3 supplementation were associated with a 25% and 33% reduction in mortality within 30 days of COVID-19 infection. Vitamin D holds promise for reducing the severity of the COVID-19 pandemic.
Dear friends who are "positive" and "not positive", in the post-epidemic era, improves immunity and slows down the subsequent harm caused by viruses to the body. Do you know what to do?
Reference:
[1] Thomas S, Patel D, Bittel B, Wolski K, Wang Q, Kumar A, Il'Giovine ZJ, Mehra R, McWilliams C, Nissen SE, Desai MY. Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection: The COVID A to Z Randomized Clinical Trial. JAMA Netw Open. 2021 Feb 1;4(2):e210369. doi: 10.1001/jamanetworkopen.2021.0369. PMID: 33576820; PMCID: PMC7881357.
[2] Quek AML, Ooi DSQ, Teng O, Chan CY, Ng GJL, Ng MY, Yee S, Cheong EW, Weng R, Cook AR, Hartman M, Angeli V, Tambyah PA, Seet RCS. Zinc and vitamin C intake increases spike and neutralizing antibody production following SARS-CoV-2 infection. Clin Transl Med. 2022 Feb;12(2):e731. doi: 10.1002/ctm2.731. PMID: 35184404; PMCID: PMC8858613.
[3] Izzo R, Trimarco V, Mone P, Aloè T, Capra Marzani M, Diana A, Fazio G, Mallardo M, Maniscalco M, Marazzi G, Messina N, Mininni S, Mussi C, Pelaia G, Pennisi A, Santus P, Scarpelli F, Tursi F, Zanforlin A, Santulli G, Trimarco B. Combining L-Arginine with vitamin C improves long-COVID symptoms: The LINCOLN Survey. Pharmacol Res. 2022 Sep;183:106360. doi: 10.1016/j.phrs.2022.106360. Epub 2022 Jul 19. PMID: 35868478; PMCID: PMC9295384.
[4] Gibbons JB, Norton EC, McCullough JS, Meltzer DO, Lavigne J, Fiedler VC, Gibbons RD. Association between vitamin D supplementation and COVID-19 infection and mortality. Sci Rep. 2022 Nov 12;12(1):19397. doi: 10.1038/s41598-022-24053-4. PMID: 36371591; PMCID: PMC9653496.
Written by: Le Yi
Source: WeChat public account "Meisi Medical"
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