Recently, China Petroleum and Chemical Industry Federation organized experts to hold a scientific and technological achievement appraisal meeting on "Green Biomanufacturing Technology and Application of Chiral Pure Glufosinate (Pure Glufosinate) Herbicide." This result was jointly developed by East China University of Science and Technology Professor Wei Dongzhi's team and Yongnong Bioscience Co., Ltd. (hereinafter referred to as "Yongnong Bio").
The experts of the appraisal committee are composed of Beijing University of Chemical Technology Academician Tan Tianwei, Zhejiang University of Technology Academician Shen Yinchu, China Petrochemical Corporation Academician Cao Xianghong, Nanjing University of Technology Academician Ouyang Pingkai, East China Normal University Qian Xuhong Academician, Guizhou University Academician Song Baoan, Fudan University Academician Chen Fen'er, Jiangsu Industrial Technology Research Institute Academician Ying Hanjie, Shanghai Huayi Group Company Wei Jianhua Professor-level senior engineer , Central China Normal University It is composed of 15 senior experts including Professor Yang Guangfu, China Sinochem Group Company Professor Liu Changling, Zhejiang UniversityProfessor Li Yongquan,Tsinghua UniversityProfessor Liu Dehua,Tianjin UniversityProfessor Jiang Zhongyi,Jiangnan UniversityProfessor Liu Liming. . Deputy Director of Sinopec Federation Zeng Chunyang, Vice President of East China University of Science and Technology Zhu Weihong, Dean Zhao Liming and Vice Dean Jia Yunfei of the Academy of Science and Technology, Dean Zhuang Yingping of the School of Bioengineering and all members of the project team attended the appraisal meeting.
Wei Dongzhi made a work report, technical report and application report on the scientific and technological achievements on behalf of the completion unit. The participating experts listened to the relevant reports and conducted a detailed review and serious discussion of the relevant technical materials. Experts attending the meeting agreed that this project developed a new multi-enzyme cascade biocatalytic production process for L-glufosinate ammonium, which is a successful example of biomanufacturing and production of pesticide varieties. This project has built a world-leading biotechnology production line with an annual output of 5,000 tons of L- glufosinate-ammonium , and has taken the lead in realizing the industrialization of L-glufosinate-ammonium's green bio-manufacturing process. Yongnong's large-scale biological production of L-glufosinate is at the forefront of the world, which has effectively promoted industrial upgrading and achieved significant economic and social benefits.
According to statistics, the global annual consumption of glufosinate-ammonium is nearly 50,000 tons, making it one of the largest non-selective herbicide varieties. my country is a major producer and exporter of glufosinate in the world, with supply capacity approaching 65% of the world. As a chiral pesticide, chemically synthesized glufosinate is composed of 50% L-glufosinate-ammonium effective form and 50% D-glufosinate-ammonium ineffective form, which means that the world suffers from the chiral waste and waste of D-glufosinate-ammonium every year. The pollution can reach tens of thousands of tons.
With the Ministry of Agriculture "Zero Growth in Pesticide and Fertilizer Use" action plan, green prevention and control, reduction and efficiency increase have become the global irreversible direction of the pesticide industry. The development of high-efficiency, low-toxicity, green pesticides has become a New trends in the development of the pesticide industry.
For a long time, the synthesis of chiral pure drugs has been a research hotspot in the field of medicinal chemistry. "Chiral intermediate method, asymmetric catalysis method and chiral resolution" are considered to be the classic theoretical methods of chiral chemical synthesis. When chemical synthesis of glufosinate-ammonium fails to achieve a breakthrough, biocatalysis has shown its potential to replace traditional chemical synthesis due to its advantages of strict stereoselectivity, mild reaction conditions, and high yield.
Yongnong Biotechnology teamed up with experts in the field of biocatalysis and biosynthesis and the team of Professor Wei Dongzhi to carry out the special research on "Green Biomanufacturing Technology and Application of Chiral Pure Glufosinate (Pure Glufosinate) Herbicide". With the help of Professor Wei Dongzhi's team With more than ten years of technical advantages in enzyme engineering and biocatalysis and Yongnong Biotech's accumulated experience in the production and application of glufosinate-ammonium, we have innovated high activity and high enantioselectivity around the key green bio-manufacturing technologies of glufosinate-ammonium. Enzyme customization technology and multi-enzyme self-assembly biocatalysis technology have created a reaction system with high substrate concentration and pure water. Through biocatalysis technology, nearly 100% of glufosinate-ammonium racemate (D, L-glufosinate-ammonium) can be converted into The efficiency is converted into refined glufosinate-ammonium (L-glufosinate-ammonium), which has significant cost advantages. Its technical level and product quality are both internationally leading, and it has formed a scientific and technological innovation system with independent intellectual property rights.
This project was industrialized at Yongnong Biotech’s Zhejiang Shangyu factory, and a new biocatalytic production line with an annual output of 5,000 tons of refined glufosinate-ammonium was built, and it was the first to obtain the technical certificate and preparation certificate. The biological method of purified glufosinate-ammonium product Jinbaisu® (10% purified glufosinate-ammonium SL) was launched as early as 2020 and successfully entered the international market. As a result, "Jinbaisu" has also won many honors such as the most explosive product in China's plant protection market in 2020 and the ingenious product in China's agrochemical industry.
article source: network
