finally got pregnant, but s spontaneous miscarriage , which is a fertility nightmare for every couple. In recent years, the phenomenon of miscarriage has shown a significant upward trend.
The definition of miscarriage is: pregnancy is less than 28 weeks old and the fetal weight is less than 1000g and the pregnancy is terminated is called miscarriage. When there are 2 or more spontaneous miscarriages in a row, you must pay attention to it, which is recurrent miscarriage (RSA). Many patients who encounter recurrent abortion pay more attention to the choice of abortion surgery method and recovery after abortion, but ignore the preservation of abortion. Why should save abortions? This is closely related to the cause of the miscarriage.
What are the causes of miscarriage
There are many causes of spontaneous abortion in early pregnancy. It is currently believed that there are genetic factors, anatomical factors, immune factors, endocrine factors, infection factors, pre-thrombotic status, etc. . Genetic factors are the main causes of recurrent miscarriage of , accounting for at least 60%.
The genetic factors that cause repeated miscarriage of include chromosomal abnormalities and genetic abnormalities.
① Couple's own gene or chromosome abnormality leads to gene or chromosome abnormality inherited by the embryo; ② Couple's gene or chromosome normal, but new gene mutations or chromosome abnormality occur during embryo formation.
It is worth paying attention to that older women are more likely to have miscarriages. The risk of miscarriage increases with the age of pregnant women. The risk of middle-class in pregnant women over 35 years of age increases to about 35%.
Why should abortion be saved
In order to avoid the recurrence of tragedy, couples who have experienced miscarriage should be sure of the cause of the miscarriage. Whether it is an "accidental phenomenon" can only be known after finding the reason. Genetic factors account for a large proportion of miscarriage. If the cause cannot be clarified clinically, it is recommended to perform genetic examination of abortions. It can explain whether there are genetic factors in this miscarriage and guide the miscarriage couple to choose the correct treatment for the next childbirth.
If the cause of two or more miscarriages is genetic factors, you can choose the third-generation IVF method to assist pregnancy to avoid the great harm caused to the body and psychology of repeated miscarriages. If abortion is a non-genetic factor, further improvement of examinations can be found to find other causes of miscarriage, and targeted.
Therefore, if you encounter miscarriage in clinical practice, you should keep the abortion, because the cause can be found through the examination of the abortion tissue, which is crucial for the next childbirth. Don’t be lucky and think that this is just an accident.
POC—Abortion chromosome detection
POC chromosome detection refers to the method of chromosome detection on abortion tissue. Using the second-generation high-throughput sequencing technology and combining advanced bioinformatics analysis to determine whether there are abnormalities in the chromosomes of abortions is an important means to check the causes of spontaneous abortion and fetal disability.
molecular genetic testing of abortion tissue can conduct comprehensive analysis of chromosome aneuploid, single parent diploid, triploid, heterozygous deletion of more than 5Mb, and fragments above 100kb or fragments above 100kb, assist in diagnosis of the causes of miscarriage, comprehensively check the causes of miscarriage and fetal discontinuation, and provide guidance for reproduction.
Testing process Step 1 Genetic consultation: Fill out the inspection form and informed consent form Step 2 Sample collection: Abortion tissue 0.5mm2 (sized soybean grains), peripheral blood 5ml Step 3 Sample transportation: 2-8°C refrigerated transportation Step 4 Molecular genetic testing of abortion tissue: POCA 9 natural days; POCB 10 natural days; POCC 25 natural days Step 5 Test report: Issuing a test report
So when abortion occurs, it is more important to find the root cause of the miscarriage to be targeted for treatment to prepare for the next pregnancy
5 So when abortion occurs, it is more important to find the root cause of the miscarriage to be accurate.
