During ten-month pregnancy, otherwise healthy people may develop some complications. If early detection and intervention are not possible, it may bring great health risks to pregnant women and fetuses, such as " acute fatty liver in pregnancy ".
Acute fatty liver of pregnancy (English: acute fatty of pregnancy, abbreviation: AFLP) refers to acute liver failure caused by decreased liver metabolic capacity without other reasons.
1. Acute fatty liver during pregnancy: rapid onset, high mortality rate
When it comes to fatty liver, everyone will immediately think of fatty liver detected by physical examination, which will be associated with obesity, drinking, etc. But the only cause of acute fatty liver during pregnancy is pregnancy. Moreover, the onset is sudden, the progression is rapid, and the mortality rate is high.
According to my country's first "Clinical Management Guidelines for Acute Fatty Liver Disease in Pregnancy", acute fatty liver disease during pregnancy is a rare and critical disease unique to pregnancy. The incidence rate is between 1/7000-1/20000, and the maternal and infant mortality rate once reached 75%-85%.
Now, with the understanding of this disease and the improvement of medical examination technology, although it has dropped significantly, the maternal mortality rate is still as high as 12.5%-18%, and the perinatal mortality rate is as high as 7-58%.
In addition, the symptoms of patients with acute fatty liver disease during pregnancy, such as vomiting and fatigue, are similar to those during pregnancy. Patients can easily think that these are normal reactions during pregnancy and therefore delay seeking medical treatment.
Even if the patient goes to see a doctor, it is difficult to make a diagnosis due to the lack of specificity of clinical symptoms and signs, and it is easy to be misdiagnosed. Early diagnosis and effective treatment of acute fatty liver during pregnancy are critical. Studies have shown that if the patient's illness lasts longer than two weeks, the mortality rate will increase significantly. If it is not treated in time in the early stage, it will lead to sudden and violent onset in the later stage.
2. The onset time of acute fatty liver in pregnancy
Although fatty liver in pregnancy has the characteristics of high fatality rate, strong concealment, and sudden onset, if you can know some basic common sense, you can make correct judgments in time at the early onset of the disease. , this disease is still treatable and preventable.
First of all, we need to be clear that fatty liver of pregnancy may occur at all stages of pregnancy, and is more common in the third trimester of pregnancy, usually between 30 and 38 weeks. Domestic research shows that it can appear as early as 23 weeks of pregnancy. Most of them are primiparous women around 35 weeks of gestation, and there is an obvious risk of multiple pregnancies.
Fatty liver disease in pregnancy has an average incubation period of 1-21 days before the disease develops and worsens. If you experience fatigue, nausea, vomiting, upper abdominal discomfort or right upper quadrant pain in late pregnancy, you need to seek medical treatment promptly and proactively report your symptoms to the doctor.
3. How to cure it?
The best way to treat fatty liver during pregnancy is to deliver the fetus as soon as possible and end the pregnancy. So far, no case of improvement before delivery has been found. The choice of delivery method of the fetus requires detailed analysis of specific issues .
Natural delivery can minimize the risk of wound bleeding for pregnant women with hemagglutination dysfunction, but the labor process may take a long time and may aggravate the condition. Caesarean sectionAlthough the delivery process can be ended as soon as possible, it may cause heavy bleeding.
The prognosis of fatty liver disease during pregnancy is highly related to the doctor's diagnosis level, detection methods and treatment options. The key to prognosis is highly related to the severity of the disease, the timing of clinical identification, and whether the termination of pregnancy is timely.
If these are done promptly, most patients will have a good prognosis, with blood coagulation function recovering in about 1 week, liver and kidney damage returning to normal 1 month after delivery, and no chronic liver disease sequelae.
In the past, due to backward medical conditions and technological means, giving birth to children was a life-and-death experience. Although medical conditions and technical means have been greatly improved, as non-professionals, ordinary people still know very little about rare diseases such as acute fatty liver of pregnancy.
hopes that all of you who read this article can move your finger and repost it, so that more people can understand rare diseases like acute fatty liver of pregnancy. When the disease occurs, they can pay attention to it, seek medical treatment as early as possible, and reduce harm.
