Recently, a new research result published in Nature-Chemistry shows that "eating soil" can also regulate the intestinal microbiome and treat enteritis. In ancient times, there was "Guanyin soil" and now there was "Double Eleven" to eat soil. Unexpectedly, one day, netizens used their own ridicule words to be true, and there were unexpected benefits.
Fanwen Technology aggregates massive network information data, accurately gathers and analyzes search topics, automatically refines keyword networks based on neural networks and knowledge graphs, and generates AI intelligent dynamic map , taking you to learn about this magical "ground".
Core keywords Relationship map
map shows: Soil has the highest attention, followed by keywords such as components, enteritis, ecology, intestine, microorganisms, materials, etc. What is "earth" in
?
scientific research team was inspired by soil components . Through artificial synthesis, it constructed soil biomimetic material , consisting of montmorillonite (natural soil component, commonly known as "Guanyin soil"), starch granules and liquid metal, which has the characteristics of regulating microbial functions. This new material with responsive and regulatory functions can not only improve the efficiency of microbial synthesis chemicals, but also regulate intestinal microbial disorders and restore intestinal microecology. It has application potential in the fields of biomanufacturing and biomedicine.
This result was completed by the University of Chicago. Professor Tian Bozhi is the corresponding author of the article, Lin Yiliang is the first author and co-corresponding author, and Gao Xiang, an associate researcher at the Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, is the co-first author of the article.
can command the "artificial soil" of microorganisms
The microbial community in the natural environment is an important but understudied field. soil is recognized as the most complex and rich environment in the earth's system. According to statistics, the number of microorganisms in each gram of soil can reach tens of billions, millions of species, thousands of colonies, and myceliums exceeding 200 meters. The diversity of prokaryotes in the soil is three orders of magnitude greater than the sum of other biological species in nature.
Inspired by the soil structure and components, the research team developed a new soil bionic material and built a chemical system that allows the microorganisms who "joined" the chemical system to colonize and send the information they want to transmit to the microorganisms in the group through physical stimulation methods. The microorganisms who were originally "free" can carry out innovative work after receiving the information.
Soil bionic materials can respond to lasers, solvents, external forces, etc. causes chemical heterogeneity to change from atoms to macroscopic level , realizing the modification of chemical redistribution, sensing, writing and erasing of different components in the chemical system, thereby exerting new functions, and the scientific research team can conduct more series of research on this basis.
"We used a bottom-up method to simulate minerals, organic phases in the soil and mobile phases to synthesize a new chemical system. This chemical system is a soil biomimicry material that can enhance microbial metabolism and improve the synthesis of bio-based chemicals in vitro, enrich the diversity of the intestinal microbiome under pathological conditions, and regulate bacterial disorders in the body." Gao Xiang said.
Perfect combination of nanostructured minerals, starch particles and liquid metals is a difficult point in the research process. The proportional adjustment and function of the three elements of are indispensable. To this end, the research team used 3D-X-ray fluorescence spectroscopy and stacked diffraction imaging to characterize the structure and function of the construction system, and repeatedly adjusted to ensure the optimal effect of the material.
Scientific "eating soil" can treat intestinal diseases
From the thinking of inorganic and organic combination in nature, to innovatively apply soils that can be seen everywhere to scientific research, and better combine materials with microorganisms according to the soil structure. This is another innovative breakthrough for the scientific research team in the field of materials.
So, how do confirm that the research results have a regulatory effect on intestinal microorganisms?
To this end, the research team established a mouse model for intestinal microbial disorders. After the mice "eat" the soil bionic materials developed by the research team, they found that their disordered intestinal microbial bacterial flora had recovered and re-established the ecological model; in addition, they found that this material can also be used to treat acute enteritis induced by dextran sodium sulfate. uses soil biomimicry materials to treat mouse models to , which confirms the regulatory function of the intestinal microbiota and the treatment of enteritis, indicating that "eating soil" can treat intestinal diseases.
"Our research results mainly have two application areas. One is that promotes the growth of microorganisms and improves the efficiency of microorganisms to synthesize bio-based chemicals, and the other regulates intestinal microecology , thereby achieving the effect of treating intestinal diseases." Gao Xiang said.
