Everything Editor: Bi Luming
A few days ago, #Changsha found a case of "dinosaur blood"# was on the hot search on Sina Weibo.
When it comes to rare blood type , everyone will think of RH negative "panda blood". But there is also a type of blood type that is more rare than panda blood , and is called "dinosaur blood", which is the Mumbai-like type. It is reported that this type of blood type was first discovered in Mumbai, India in 1952, and is extremely rare in China. The proportion of people with this type of blood type in the country is only one in a hundred thousand, and there are only more than a hundred cases in the country. Because this type of "Mumbai-like blood type" is very rare, its value and significance are particularly significant. Recently, a Mumbai-like blood type was found in the Laboratory Department (Dermal Transfusion Department) of Changsha Fourth Hospital.
A case of "dinosaur blood" was found in Changsha. Quanzhou A mother also measured
According to the official Weibo 22 report on the 22, not long ago, a minority pregnant mother visited Changsha Fourth Hospital . During the diagnosis and treatment process, Liu Qianxi, deputy chief examiner, found that the positive and negative blood type of the pregnant woman did not match the positive and negative blood type. The positive and negative blood type showed that the positive blood type of the B type feature, which was positive for screening and negative for itself. The abnormal result immediately aroused her high vigilance. She immediately contacted the pregnant woman to find out the situation. The pregnant woman gave birth to her two children in an outer hospital and her blood type was O type . Liu Qianxi immediately reported the situation to the department director Zhang Biming, who organized the department to conduct in-depth research on this difficult blood type. After review of different related blood types such as anti-H, saline anti-sieve method, absorption and dispersion experiment, microcolumn gel method, test tube method, was initially considered as a Mumbai-like blood type.
Image source: Changsha Political and Legal Channel Screenshot
To ensure the accuracy of the test results, Director Zhang Biming led the blood transfusion department personnel to continue to read a large amount of information and consulted blood transfusion experts inside and outside the province. The experts suggested blood type gene testing. Due to the limited testing conditions of the hospital and the actual blood type of the pregnant woman, after fully communicating with the pregnant woman, Liu Qianxi contacted West China Hospital for free blood type gene testing for the pregnant woman.
On October 11th, final result returns: the patient's serology is Mumbai-like type B. The sequencing results of FUT-1 gene comply with FUT1*01W.37 (weak expression of H antigen) published by the ISBT International Society of Transfusion. The sequencing results are shown as FUT1*01W.37//FUT1*01W.37. The results of ABO gene sequencing are in line with B101/O02 published by the ISBT International Society of Transfusion. The patient's gene expression was normal B glycosyltransferase activity, and the ABO glycosyltransferase gene mutation was excluded to lead to ABO subtype.
Coincidentally, this year, a mother born in Quanzhou also measured "dinosaur blood". According to Quanzhou.com in September, Ms. Su, a mother living in Anxi, Quanzhou, had a cesarean section at , (hereinafter referred to as , Fu Medical Second Hospital, ). After testing and identification, she was Mumbai-like AB blood type in "dinosaur blood". Relevant information shows that only more than 100 cases of this type of Mumbai blood type have been found nationwide. reporter learned that 15 cases of "dinosaur blood" have been found in Quanzhou Central Blood Station in daily blood donation, and all of them have established corresponding blood type files, but "dinosaur blood" has been further subdivided into a variety of, and the "completely the same model" is extremely rare. "The donated blood has a certain shelf life, and the interval between a person's blood donation cannot be less than 6 months, so rare blood types are generally recruited when there is an urgent need." The staff said.
Mumbai blood type is a rare red blood cell blood type, belonging to the Hh blood type system . This blood type is very "crawling" and will initially show O-type characteristics during detection. Ms. Su has participated in blood donation twice. She had always thought she had O blood type . A staff member called her when she donated the blood for the second time and told her that it might be a rare blood type and asked her to undergo further testing. "It was the first time I heard that I didn't listen carefully when answering the phone. Later, I called back and wanted to ask again, but the other staff answered the phone. If I didn't know the situation, it would be left alone."
Ms. Su was diagnosed with "dinosaur blood", her mother, sister and sister also went for a checkup. "My mother and sister are B blood type . My sister, who is the same as my father and mother, is also a Mumbai-like blood type. , but there has not been further detection and analysis. Which of the Mumbai-like blood type is?"
Image source: Photo Network-501514500
What is Mumbai-like blood type?
Mumbai blood type was first discovered in Mumbai, India in 1952, and Mumbai-like type was discovered in 1961. Both Mumbai-like and Mumbai-like types are rare red blood cell blood types and belong to a very important Hh blood type system. The difference from the ABO blood type system is the lack of H antigen.
type Mumbai type has limited cases reported worldwide, commonly known as "dinosaur blood". It is reported that the ratio of Mumbai-like type to Mumbai-like type is 1:15. The Mumbai-type or Mumbai-like population has familial genetic characteristics. If the patient needs blood transfusion treatment, the probability of conducting a family survey to find the same blood type is relatively high.
When such people need blood transfusion, it is best to undergo autologous blood transfusion or infusion of blood that is deficient in homotype H antigen. When emergency blood transfusion is required without the same type or without autologous transfusion, the ABO homotypic blood that does not respond to the patient's serum or the weakest response should be first injected to minimize the risk of hemolysis. During the infusion process, it is necessary to closely observe whether adverse blood transfusion reactions occur to fully ensure that the patient can undergo blood transfusion treatment safely and effectively.
Two cases of gold blood type were found in Jiangsu
It is reported that the Taizhou People's Hospital affiliated to Nanjing Medical University had previously received a severe anemia woman. When she was tested for blood type and blood type antibody, she found that she was not only RhD negative (commonly known as panda blood), but also her RhC, Rhc, RhE, and Rhe were all negative (RhNULL). In addition, her ABO blood type was O type, and there was no blood type antigen on red blood cells . This means that if she acts as a blood donor, she can provide her own blood to any patient who needs a blood transfusion.
Gao Lingbao, director of the infusion department of the hospital, introduced that the investigation found that the patient's blood type of the patient's biological sister was the same as hers, and they were all O-type RhNULL. The RhNULL blood type is said to be called the golden blood type, and the probability in the population is one in six million. Since the blood type was discovered in the 1960s, there have been less than 50 cases worldwide, and there were only 4 cases previously reported in China.
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