In recent days, an exciting medical news has flooded the screen! That is, the world's first new drug developed by Chinese people is on the market!
For a long time, in the field of chemical drugs, my country has basically followed the pace of foreign countries, mainly generic drugs, especially in diabetes treatment drugs. Now, this situation will completely change. Recently, my country independently developed and developed the world's first new anti-glycemic drug, Dogliasetin, has been approved for marketing. This is not only a blessing for the majority of diabetic patients, but also marks that we finally have the truly first anti-glycemic drug in our country.
Although this news has been on the Internet, dogliatine is still very unfamiliar to the majority of diabetic friends. How does this medicine work? Can it replace insulin injection? Let’s answer it for you today.
After ten years of hard work, the first new anti-glycemic drug in my country has finally been released
As diabetes has become a global disease, research on the pathogenesis of diabetes has also become a hot topic in recent years. Based on the new glucose kinase activator (GKA), a team of Chinese scientist Professor Zhu Dalong, has successfully developed this world's first GKA drug, Dogliasetin, based on the target of diabetes, and was the first to complete clinical verification. This process took ten years and can be said to be a "ten-year sword". The relevant research results were published in Nature Medicine, the top international medical journal in June this year.
How does dogliadetin play a role in lowering glycemic?
glucose kinase is a key enzyme that regulates sugar metabolism in the body. It can play an important role in regulating human blood sugar. It is known as the glucose sensor, but 2 diabetes patients generally have a reduced activity in the enzyme. As the world's first glucose kinase activator, doglitazine can restore glucose kinase activity, thereby adjusting insulin secretion, improving systemic insulin resistance, promoting liver glycogen synthesis, and achieving the purpose of regulating systemic blood sugar homeostasis and balance. According to Professor Zhu Dalong, this drug has achieved the treatment of diabetes from the source. For patients with islet function, is still good, this drug can also protect islet cells and avoid excessive failure of islet cells. It can be said that it brings double insurance to patients with type 2 diabetes.
can dogliasetin replace insulin ?
This is a very concerning issue for many diabetics! Because many diabetics think it is very inconvenient to inject insulin, so they resist insulin injection.
According to the clinical trials of dogliasetine single agent and combined with metformin for the treatment of diabetes, it does show a strong therapeutic effect, , but unfortunately, it cannot completely replace insulin at present.
diabetic patients usually need to use insulin in two situations. One is when the patient's pancreatic islet cell function is almost exhausted and the secreted insulin can no longer meet the body's needs. From the perspective of mechanism of action, although dogliasetin can activate glucose kinase activity, if the body does not have the prerequisite for lowering insulin from insulin as a sugar level, then dogliasetin cannot play its due role. Therefore, those who must use insulin to lower the sugar level should not blindly stop using insulin and switch to dogliatine, but they can try to use it in combination, which may reduce the dosage or number of injections. The approval of
Dogliasetine for sale indicates that diabetics have another choice in the treatment of diabetes. How to match it with other antidiabetic drugs? is still recommended to use under the guidance of a doctor, because we need to look at any new drug objectively. After all, its efficacy and safety require time to verify!
