M. Autonomous University of Madrid, Spain.

2024/05/1017:59:32 science 1275

M. Llorens-Martín and other researchers from the Autonomous University of Madrid in Spain analyzed the human brain hippocampus (hippocampus, responsible for long and short-term memory, spatial positioning, etc.) is believed to have lifelong nerve cell regeneration activities and contribute to neuroplasticity. Changes in the (dentategyrus (DG)) region in aging and various neurodegenerative diseases. It is found that with aging and neurodegenerative diseases, the homeostasis of the dentate gyrus region is destroyed, which is manifested as: an increase in microvessels, small Decreased phagocytic capacity of glial cells (microglia) , astrogliosis (astrogliosis) , and accompanying impairment of adult hippocampal neurogenesis (AHN) activity.

The researchers said that this work directly analyzed the changes of its key components with aging and neurodegenerative diseases directly in the dentate gyrus of the human brain. The study of this dynamic process can reveal adult hippocampal neuroregeneration, which is very important in the adult brain. Rare nerve regenerative activities, specific physiological functions.

This work was published in Science(1) on October 22, 2021.

Comments:

It is quite unique to compare the changes in multiple neurodegenerative diseases at the same time. It can provide many clues based on specific disease manifestations. In addition, in the future, further combination of single cell sequencing , spatial transcriptome and animal experiments can further answer the questions about the hippocampus. Physiological functions of nerve cell regeneration and its potential regulatory mechanisms.

Corresponding author introduction:

https://scholar.google.com/citations?user=oia75dAAAAAJ&hl=es

References:

1. J. Terreros-Roncal et al., Impact of neurodegenerative diseases on human adult hip pocampal neurogenesis. Science(80- . ). (2021), doi:10.1126/SCIENCE.ABL5163.

Original link:

https://www.science.org/doi/10.1126/science.abl5163

science

Along this road, there will be street lights shining through the gaps in the leaves and scattered around your feet. But tonight, it was dark all around. Except for the faint light from the mobile phone screen, I couldn't see my fingers, but it seemed that even this weak light wou - DayDayNews

Along this road, there will be street lights shining through the gaps in the leaves and scattered around your feet. But tonight, it was dark all around. Except for the faint light from the mobile phone screen, I couldn't see my fingers, but it seemed that even this weak light wou

I feel like I'm seriously ill

06/03 1579

First of all, the possibility of ants having human intelligence in real life is almost zero. Because the intelligence of all insects, including ants, is not as good as some lower animals with high intelligence. In other words, insects have the lowest IQ. For example, some animals - DayDayNews

First of all, the possibility of ants having human intelligence in real life is almost zero. Because the intelligence of all insects, including ants, is not as good as some lower animals with high intelligence. In other words, insects have the lowest IQ. For example, some animals

What would happen if ants possessed the aerospace intelligence of human science?

06/03 1488

On July 5, local time, NASA stated that the U.S. Capstone CubeSat "lost contact" while leaving the earth's orbit and heading towards the moon. - DayDayNews

On July 5, local time, NASA stated that the U.S. Capstone CubeSat "lost contact" while leaving the earth's orbit and heading towards the moon.

The U.S. lunar exploration satellite lost contact, the "return to the moon" plan may be postponed again, and the Pentagon is nervous

06/03 1681

Our solar system is located at the center of a relatively empty region of space. This cavity has an extremely low particle density, at least 10 times lower than the average density of the interstellar medium in our galaxy. This cavity, known as the local bubble, is where our sun - DayDayNews

Our solar system is located at the center of a relatively empty region of space. This cavity has an extremely low particle density, at least 10 times lower than the average density of the interstellar medium in our galaxy. This cavity, known as the local bubble, is where our sun

The solar system is surrounded by a huge cosmic bubble. How was this cosmic bubble formed?

06/03 1688

On the 5th local time, the latest winner of the 2022 Fields Medal was announced at the International Mathematical Union Awards Ceremony held in Helsinki, the capital of Finland. Four young mathematicians from France, the United States, the United Kingdom and Ukraine were awarded - DayDayNews

On the 5th local time, the latest winner of the 2022 Fields Medal was announced at the International Mathematical Union Awards Ceremony held in Helsinki, the capital of Finland. Four young mathematicians from France, the United States, the United Kingdom and Ukraine were awarded

The "Nobel Prize" in mathematics, the 2022 Fields Medal announced

06/02 1714

The Tobacco Research Institute of the Chinese Academy of Agricultural Sciences, in collaboration with universities at home and abroad, has effectively reduced the phytotoxic effects of sulfonylurea herbicides on subsequent sensitive crops based on single-atom modified nanomateria - DayDayNews

The Tobacco Research Institute of the Chinese Academy of Agricultural Sciences, in collaboration with universities at home and abroad, has effectively reduced the phytotoxic effects of sulfonylurea herbicides on subsequent sensitive crops based on single-atom modified nanomateria

Worried about herbicide damage? Nanomaterial degradation technology is coming

06/02 1106

Acid and alkali resistant magnetic pumps can transport harsh fluid media such as highly toxic, flammable and explosive, high power, high temperature, high pressure and strong corrosion resistance. Because of its performance advantages of no shaft seal and no leakage, in recent ye - DayDayNews

Acid and alkali resistant magnetic pumps can transport harsh fluid media such as highly toxic, flammable and explosive, high power, high temperature, high pressure and strong corrosion resistance. Because of its performance advantages of no shaft seal and no leakage, in recent ye

How much do you know about the four major advantages of acid and alkali resistant magnetic pumps?

06/02 1935

In 1676, Dutch scientist Antoni van Leeuwenhoek used a homemade microscope to observe bacteria for the first time and revealed the existence of microorganisms to the world. Therefore, he is also known as "the father of protozoology and bacteriology." father". - DayDayNews

In 1676, Dutch scientist Antoni van Leeuwenhoek used a homemade microscope to observe bacteria for the first time and revealed the existence of microorganisms to the world. Therefore, he is also known as "the father of protozoology and bacteriology." father".

Subvert cognition! Scientists discover the world's largest bacteria: the size of a fly, visible to the naked eye

06/02 1113

In 1994, Bill Gates spent about $30 million to purchase Leonardo da Vinci's "Code Leicester," a famous manuscript that records Leonardo da Vinci's work on astronomy, mechanics, botany, mathematics, and Sketches and ideas for subjects such as architecture. Why spend so much money - DayDayNews

In 1994, Bill Gates spent about $30 million to purchase Leonardo da Vinci's "Code Leicester," a famous manuscript that records Leonardo da Vinci's work on astronomy, mechanics, botany, mathematics, and Sketches and ideas for subjects such as architecture. Why spend so much money

Learn about DeSci - making scientific breakthroughs possible

06/02 1969

On July 5, local time in the United States, NASA confirmed that CAPSTONE, the first probe in the "Return to the Moon" plan launched last week, experienced a communication failure on the way to the moon and has now completely lost contact with the earth. - DayDayNews

On July 5, local time in the United States, NASA confirmed that CAPSTONE, the first probe in the "Return to the Moon" plan launched last week, experienced a communication failure on the way to the moon and has now completely lost contact with the earth.

First launch failed! NASA's "microwave oven" probe lost contact, the US space agency began to seek cooperation from multiple countries

06/02 1249