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Human immunodeficiency virus has an "early and massive" effect in promoting the aging of infected people since infection. Within two to three years after infection, human immunodeficiency virus accelerates normal aging-related biological changes in the body. That's according to UCLA researchers and colleagues.
Research shows that compared with non-infected people, human immunodeficiency virus can shorten the life span of infected people by nearly 5 years.
"Our study shows that even months or years after human immunodeficiency virus (HIV) infection, the HIV virus enters a mode of accelerating aging in infected people at the level of DNA. This finding highlights the relevance of early HIV diagnosis and awareness of aging. The problem is critical and equals the value of preventing HIV infection in the first place," the researchers said.
The research has been published in the journal iscience.
Previous research has suggested that HIV and the antiretroviral treatments used to control HIV infection are associated with premature aging, such as heart and kidney degeneration, frailty and cognitive difficulties.
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The research team analyzed blood samples from 100 men at least six months before infection, and two to three years after infection. The researchers compared those blood samples with blood samples from non-infected people of the same age at the same time. All were participants in the AIDS Multicenter Cohort Study, a nationwide study spanning 35 years from 1984 to 2019. The study authors said the study was the first to pair infected and non-infected people.
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