Parkinson's disease is the second most common neurodegenerative disease. Its important pathological feature is the loss of mitochondrial complex I function in dopaminergic nerve cells in the substantia nigra of the brain. But does this loss cause Parkinson's disease or is it just

2024/04/2120:37:33 science 1711

https://www.nature.com/articles/s41586-021-04059-0

Parkinson's disease is the second most common neurodegenerative disease (1), and its important pathological feature is the brain's substantia nigra (substantia nigra) Dopaminergic neuronal mitochondrial complex I (mitochondrial complex I) function is lost (2), but whether this loss causes Parkinson's disease or is just a companion event is still controversial (3).

Northwestern University D. James Surmeier and other researchers used mouse genetics to provide strong evidence to support that the functional loss of mitochondrial complex I of dopaminergic neurons is sufficient to cause a series of symptoms of Parkinson's disease (4).

Researchers specifically knocked out Ndufs2, a key component of mitochondrial complex I, in dopaminergic neurons of mice and found that after a period of metabolic compensation, the mice gradually developed a series of Parkinson's disease symptoms ranging from mild to severe. , and symptoms can be alleviated by the Parkinson's disease treatment drug-levodopa, the precursor molecule of dopamine (4).

Parkinson's symptoms caused by knockout of Ndufs2 in dopaminergic neurons in mice can be alleviated by the Parkinson's disease drug levodopa

Researchers believe that this work clarifies the pathogenesis of Parkinson's disease and can help early detection of patients who are about to develop into Parkinson's disease. Kinson's disease patients and provide relief (5).

This work was published in nature(4) on November 3, 2021.

Comments:

A good animal model of Parkinson's disease; however, the "ultimate" evidence to prove this pathogenic mechanism is to develop effective drugs for the treatment of human Parkinson's disease based on this potential mechanism.

Corresponding author introduction:

https://www.feinberg.northwestern.edu/faculty-profiles/az/profile.html?xid=13458

References:

1. W. Poewe et al., Parkinson disease. Nat. Rev. Dis Prim. 3, 1–21 (2017).

2. D. J. Surmeier, J. A. Obeso, G. M. Halliday, Selective neuronal vulnerability in Parkinson disease. Nat. Rev. Neurosci. 18, 101–113 (2017).

3. H. W. Kim et al. al., Genetic reduction of mitochondrial complex I function does not lead to loss of dopamine neurons in vivo. Neurobiol. Aging. 36, 2617 (2015).

4. P. González-Rodríguez et al., Disruption of mitochondrial complex I induces progressive parkinsonism. Nature(2021), doi:10.1038/S41586-021-04059-0.

5. Gene therapy boosts Parkinson's disease drug benefits -- ScienceDaily, (available at https://www.sciencedaily.com/releases/2021/11 /211103140100.htm).

Original link:

https://www.nature.com/articles/s41586-021-04059-0

science

She is Liu Yang. She officially entered space in 2012 and set an initial example for subsequent female astronauts. She is a sonorous rose that must be mentioned in the history of Chinese spaceflight. - DayDayNews

She is Liu Yang. She officially entered space in 2012 and set an initial example for subsequent female astronauts. She is a sonorous rose that must be mentioned in the history of Chinese spaceflight.

How do female astronauts solve the "privacy" issue in space? Will blood flow backward during menstruation?

05/14 1330

Rare genetic variants in LMNA are known to cause dilated cardiomyopathy alone or in conjunction with conduction defects, and in some cases the only manifestations are conduction delays, atrial arrhythmias, or ventricular arrhythmias. - DayDayNews

Rare genetic variants in LMNA are known to cause dilated cardiomyopathy alone or in conjunction with conduction defects, and in some cases the only manifestations are conduction delays, atrial arrhythmias, or ventricular arrhythmias.

Advances | LMNA variants and risk of heart disease in adulthood

05/14 1116

The mysterious species-"anchovy" appears? Recently, according to media reports, researchers from Xiaogan City, Hubei Province discovered an extremely rare fish - anchovy during an inspection in a suburban river. It is reported that researchers once believed that the anchovy may h - DayDayNews

The mysterious species-"anchovy" appears? Recently, according to media reports, researchers from Xiaogan City, Hubei Province discovered an extremely rare fish - anchovy during an inspection in a suburban river. It is reported that researchers once believed that the anchovy may h

Mysterious species discovered! It appeared in the Yangtze River for the first time in 10 years. It was once eaten to the point of being endangered due to its delicious meat.

05/14 1297

Developed in partnership with NASA, each episode offers an unprecedented look at the lives of the astronauts who work aboard the space station, during which they serve as cast, crew and directors. - DayDayNews

Developed in partnership with NASA, each episode offers an unprecedented look at the lives of the astronauts who work aboard the space station, during which they serve as cast, crew and directors.

That’s one small step for mankind, one giant leap for VR

05/14 1976

The Antarctic continent covers an area of approximately 13.9 million square kilometers. It is an uninhabited land covered by huge ice. The average temperature is -25°C, and the lowest can reach -91°C. There are more than 300 days of level 8 winds out of 365 days a year... ...It - DayDayNews

The Antarctic continent covers an area of approximately 13.9 million square kilometers. It is an uninhabited land covered by huge ice. The average temperature is -25°C, and the lowest can reach -91°C. There are more than 300 days of level 8 winds out of 365 days a year... ...It

One billion tons of krill were discovered in Antarctica. How fierce is the competition among countries? Could China be the biggest beneficiary?

05/14 1839

On July 1, 2022, "China Daily" published "The Elk Herd in Daqingshan, Inner Mongolia Reproduced Successfully" The translation is as follows ↓↓↓ Dozens of elk are thriving in the Daqingshan National Nature Reserve in Inner Mongolia. - DayDayNews

On July 1, 2022, "China Daily" published "The Elk Herd in Daqingshan, Inner Mongolia Reproduced Successfully" The translation is as follows ↓↓↓ Dozens of elk are thriving in the Daqingshan National Nature Reserve in Inner Mongolia.

Construction of ecological civilization in Hohhot: A record of elk cultivation in Daqingshan Nature Reserve

05/13 1303

Everyone should understand that exercise is relative. That is, there is no absolute movement. So what is relative motion? When two people run at the same speed, they can be regarded as relatively stationary. This is what we call relative motion. Why can’t humans on earth feel tha - DayDayNews

Everyone should understand that exercise is relative. That is, there is no absolute movement. So what is relative motion? When two people run at the same speed, they can be regarded as relatively stationary. This is what we call relative motion. Why can’t humans on earth feel tha

Why can’t we humans feel the earth rotating at supersonic speed?

05/13 1771

Editor | Zimei Tissue-resident macrophages are important natural immune cells that are present in almost all tissues and organs of the body and play an important role in host defense, inflammatory diseases, maintenance of immune homeostasis, and tissue repair. - DayDayNews

Editor | Zimei Tissue-resident macrophages are important natural immune cells that are present in almost all tissues and organs of the body and play an important role in host defense, inflammatory diseases, maintenance of immune homeostasis, and tissue repair.

Peripheral monocyte-derived alveolar macrophages cause severe respiratory tract infections

05/13 1772

Snake is a very dangerous creature. Many people are very afraid of it, especially the highly venomous snake. People generally will not mess with it and want to hide away. The farther away from it, the better. If one If you are accidentally bitten, the consequences will be disastr - DayDayNews

Snake is a very dangerous creature. Many people are very afraid of it, especially the highly venomous snake. People generally will not mess with it and want to hide away. The farther away from it, the better. If one If you are accidentally bitten, the consequences will be disastr

Why is it said: "The bungara snake is the most venomous snake, what should you do immediately if you are bitten?

05/13 1119

Planetary scientists conducted an in-depth study of data captured by the Mars Reconnaissance Orbiter and determined that Margaritifer Terra spans the northern Ladon Valles, the southern Ladon Basin, and the southwestern highlands surrounding the basin. Clay sediment distribution. - DayDayNews

Planetary scientists conducted an in-depth study of data captured by the Mars Reconnaissance Orbiter and determined that Margaritifer Terra spans the northern Ladon Valles, the southern Ladon Basin, and the southwestern highlands surrounding the basin. Clay sediment distribution.

Martian soil shows signs of conditions suitable for life

05/13 1944