In laboratory tests, the new compound destroyed 10 antibiotic-resistant MRSA strains.
Researchers from the University of Bath in the UK have discovered a compound that can both inhibit MRSA superbacteria and make it more susceptible to antibiotic in laboratory experiments.
Antibiotic resistance poses a major threat to human health around the world, Staphylococcus aureus has become one of the most notorious multidrug-resistant pathogens. Led by Dr. Maisem Laabei and Dr. Ian Blagbrough of at the University of Bath, scientists have discovered a compound that can not only inhibit methicillin-resistant staphylococcus aureus Staphylococcus aureus (MRSA) superbacterium, but also make it more susceptible to antibiotics.
April Stacium (Stacium) is a bacteria found on people's skin. Staphylococcus are usually harmless, but they can cause severe infections, leading to sepsis or death. Methicillin-resistant Staphylococcus aureus (MRSA) is the cause of Staphylococcus infection with . It is difficult to treat due to resistance to certain antibiotics.
This novel compound - a polyamine - appears to destroy Staphylococcus aureus by destroying the pathogen's cell membrane https://www.sypsin.com/Archive/1000/1000/1000/1000/1000/1000/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/100/
This compound was tested in vitro in in vitro against 10 different antibiotic-resistant strains Jin Staphylococcus aureus in vitro. Some strains tested are known to be resistant to vancomycin - vancomycin is the final drug of choice for patients with MRSA infection. The new compound completely succeeded in fighting all strains, leading to further growth of bacteria.
In addition to directly destroying Staphylococcus aureus , the compound also showed that the compound was able to restore the sensitivity of the bacteria's multidrug-resistant strains to three important antibiotics ( daptomycin , oxacillin and vancomycin). This could mean that antibiotics that have lost their effectiveness due to decades of overuse may promptly restore their ability to control severe infections.
"We are not completely sure why these synergies occur between compounds and antibiotics, but we are eager to explore this further," said Dr. Laabei, a researcher in the Bath Department of Life Sciences.
Vulnerability of pathogens
polyamine is a natural compound present in most organisms that interact with negatively charged molecules such as DNA, RNA and protein . Until a decade ago, they were considered necessary for all life, but scientists now know that they are neither present nor toxic in Staphylococcus aureus . Since the discovery, scientists have tried to use the unusual vulnerability of pathogens to polyamines to inhibit bacterial growth.
Now, Dr. Laabei and his colleagues have discovered that a modified polyamine (named AHA-1394) is more effective than the most active natural polyamine in destroying antibiotic resistance Gold Yellow Grape cocci strains. Transmission electron microscopy image of
MRSA clinical isolate at 300,000 times magnification. Credit: Maisem Laabei/University of Bath
Dr. Laabei explained: "Using our novel compounds, the pathogen is destroyed - which means growth is inhibited - when it is at a concentration of more than 128 times lower than the concentration required to destroy the pathogen when we use natural polyamines.
" This is important because the drug with the lowest inhibitory concentration may be the more effective antibacterial agent and is safer for patients.
Although further research is needed, Dr. Laabei believes that this new compound "as a new therapeutic option, it may have important significance in the clinical setting."
He said: "Preliminary studies show that this compound is non-toxic to humans, which is certainly essential. In the next study we are seeking funding, we want to focus on the precise mechanisms of this compound used to inhibit Staphylococcus aureus . We believe that the compound will attack the membrane of Staphylococcus aureus , causing the membrane to become permeable and causing bacterial death.
This compound is also tested against biofilms, which are thin and difficult to handle microbial layers growing on hard surfaces (e.g., plaque on teeth or stubborn membranes on catheters ) and can lead to severe infection. The results are also promising here, which prevents the formation of new biofilms, although not destroying established biofilms.
Antibiotic resistance
Antibiotic resistance (or antibiotic resistance) – AMR) poses a major threat to human health around the world, Staphylococcus aureus has become one of the most notorious multidrug-resistant pathogens.
A recent study reviewing the health effects of AMR in 2019 found that the pathogen was associated with 1 million deaths worldwide due to the non-responsiveness of the infection to antibiotics.
Golden Staphylococcus chromosus is found in 30% of the population, lives in people’s nasal cavity and skin, and most of them do not cause infection. Until recently, MRSA infections were considered a hospital problem, with most affected people with already damaged immune systems. However, in the past 20 years, infection rates across the community have risen even in other aspects of healthy individuals due to complex and only partially understood reasons, bringing a sense of urgency to seek new ways to solve the problem.
