[Literature Interpretation]
There is now sufficient evidence that psychological stress can increase inflammation in the brain, which is a known mediator of many diseases. However, the long-term consequences of chronic psychological stressors that cause neuroinflammatory reactions are still unknown. In January 2012, Emory University studied the increased susceptibility to inflammation and changes in inflammation during adulthood in mice receiving chronic predatory stress. And published the relevant results in the journal "Journal of Neuroinflammation". In the
experiment, mice are used as a model to first determine whether chronic predatory stress (PS) or stress modulates inflammation as a mechanism that may mediate behavioral deficits; secondly, determine whether long-term exposure to pure psychological stressors It can lead to psychological and physical defects; finally, in order to determine that acute PS has neuroinflammatory consequences, the inflammatory changes in adult mice are examined at different time points after PS.
The results showed that the basal expression of inflammation in the brain increased in adolescent mice receiving chronic PS. Stressed and chronic PS mice also had impaired inflammatory responses to subsequent lipopolysaccharide attacks, and PS mice showed increased anxiety and depression-like behaviors after chronic stress. Finally, the gene expression of inflammatory factors in PS adult mice increased.
Note: Stress and chronic PS can increase depression, anhedonia and anxiety-like behaviors.
In summary, stress can cause neuroinflammation and behavioral changes, as well as increase brain inflammation, leading to memory decline. At present, the experimental mouse model may help clarify the mechanism of psychological stress regulating diseases with inflammatory components, which is good news.
[Keywords] stress, brain inflammation, neuroinflammation, memory
[Original title] Psychological stress in adolescent and adult mice increases neuroinflammation and attenuates the response to LPS challenge
[title translation] Psychological stress in adolescents and adult mice increases neuroinflammation and weakens the response to LPS attacks Published magazine] Journal of Neuroinflammation
[Release time] January 2012
[Impact factor] 5.793
[Original link] https://doi.org/10.1186/1742-2094 -9-9
【Excerpts from literature】
There is ample evidence that psychological stress adversely affects many diseases. Recent evidence has shown that intense stressors can increase inflammation within the brain, a known mediator of many diseases. However, long -term ou tcomes of chronic psychological stressors that elicit a neuroinflammatory response remain unknown.
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