"Advanced Science" Zhao Nana/Xu Fujian/Wang Changyong Academician: Natural Melanin Alginate Hydrogel

2021/08/3018:37:24 science 2186

The efficacy of cardiac regeneration strategies in the treatment of myocardial infarction (MI) is greatly limited by the cardiac microenvironment. The combination of reactive oxygen species (ROS) clearance in the MI microenvironment to inhibit oxidative stress damage and macrophages polarized regeneration M2 phenotype may be ideal for MI treatment. Recently, researchers have proposed that is a melanin nanoparticle (MNPs)/alginate (Alg) hydrogel, which is composed of two natural biomaterials from marine sources, namely MNPs and MNPs obtained from cuttlefish ink. Alginate extracted from seaweed.

Figure 1 Schematic diagram of the preparation and treatment mechanism of MNPs/Alg hydrogel in cardiac repair in vivo.

uses the antioxidant properties of MNPs and the mechanical support of injectable alginate hydrogels to explore the use of MNPs/Alg hydrogels for cardiac repair by adjusting the MI microenvironment. It is found that MNPs/Alg hydrogel can eliminate ROS to combat oxidative stress damage of cardiomyocytes. More interestingly, in the presence of MNPs/Alg hydrogel can greatly promote the polarization of macrophages to regenerate M2 macrophages. MI rat model is used to evaluate the feasibility of the prepared MNPs/Alg hydrogel for cardiac repair in vivo.The antioxidant, anti-inflammatory and angiogenesis effects of hydrogel have been studied in detail. This research opens up a new method of using natural biomaterials to treat MI, and allows a new understanding of the great value of natural biomaterials in cardiac repair.

Figure 6 The effect of MNPs/Alg hydrogel on infarcted heart morphology, cytoskeleton structure, gap junction and angiogenesis 28 days after different treatments.

related thesis entitled Natural Melanin / Alginate Hydrogels Achieve Cardiac Repair through ROS Scavenging and Macrophage Polarization published in "Advanced Science". Corresponding author Yes Institute of Basic Medicine, Academy of Military Medical Sciences Academician Wang Changyong ,And Professor Zhao Nana , Professor Fujian Xu from Beijing University of Chemical Technology.

References : _p13.

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