phosphodiesterase 5 (PDE5) exists in the penis cavernosum
Health Capital Theory, October 15th At a technical press conference held yesterday, Wuhan Huiqun Targeted Gene Technology Co., Ltd. officially announced that it had discovered the mechanism of action of ginseng to strengthen aphrodisiac, and plant Viagra can become a reality, providing a new idea and choice for the prevention and treatment of ED.
According to the person in charge of Huiqun targeting genes, phosphodiesterase 5 (PDE5) is the main phosphodiesterase found in the penis cavernosum, which can specifically catalyze the hydrolysis of cyclic guanosine phosphate (cGMP). PDE5 selective inhibitors can effectively inhibit the activity of PDE5 and block the hydrolysis of cGMP, thereby increasing the concentration of cGMP and vasodilating the vessels, which plays an important regulatory role in penile erectile function.
From July 1 to October 10, Huiqun Targeting Gene Company conducted a prospective, randomized, controlled and open clinical study, and included 120 ED users, including 60 cases in the ginseng extract group and the placebo group, and patients in each group were given regular treatment for 4 weeks.
was subjected to questionnaire scores for related erectile function before enrollment, 2 weeks after taking ginseng extract, and 4 weeks after taking ginseng extract, including the International Erectile Function Score-5 (IIEF-5), Penile Erectile Hardness Grading Questionnaire, Sex Life Diary Questionnaire and Overall Assessment Questionnaire. At the same time, the detection of relevant biochemical indicators and testosterone was improved, and the effectiveness and safety of within and between groups were conducted in the two groups respectively.
After a 4-week nutritional supplement, ginseng extract has a significantly better effect than placebo in improving erectile dysfunction in men. Among the 60 cases in the ginseng extract group, 45 cases had significantly improved sexual function and the effective efficiency reached 75%.
ginseng contains a variety of medicinal ingredients and nutrients, including more than 30 ginseng saponin , as well as important active substances such as ginseng polysaccharide, polypeptide , maltol, etc., which contain more than 40 volatile ingredients, 17 amino acid , and more than 30 trace elements. In addition, it also contains a variety of vitamins and organic acids. The person in charge of
Huiqun targeting genes said that Rg1 in ginseng can target and inhibit the activity of phosphodiesterase 5 and is an effective PDE5 inhibitor, with half of its effective concentration of IC50 of 7.24 nmoI/L.
