Recently, the Lancetml2 magazine sub-blog eBioMedicine published the latest research results of the cooperation between Associate Researcher Wang Deheng of the School of Basic Medicine of our school and the team of Huashan Hospital affiliated to Fudan University, Neural excitatory rebound induced by valproic acid may predict its inadequate control of seizures in the form of Articles. This article reveals that the poor efficacy of the antiepileptic drug sodium valproate (VPA) may be caused by an abnormal rebound in nerve discharge mediated by dysbalance of VPA.
sodium valproate is one of the most effective anti-epileptic drugs (ASM) for the treatment of systemic and focal epilepsy seizures, but monotherapy for sodium valproate cannot effectively control epilepsy seizures in some patients. In this study, the research team performed awake craniotomy on 16 patients with epilepsy, and intraoperatively monitored high-density cerebral cortical potential (ECoG). The results of neuroelectroelectric signal showed that poor seizure control in patients after surgery were closely related to the abnormal significant rebound of cortical potential (excitatory rebound) after monotherapy of sodium valproate (p = 0.008), and accompanied by significant synchronous enhancement of local field potential (LFP) in the cerebral cortex.
This study further revealed that the mouse epilepsy model established by induced alginic acid (KA) drug validated that the monotherapy of valproate after epilepsy in animals reproduced the excitatory rebound of neuroelectric activity (53/77 neurons, 68.83%), and was accompanied by significant enhancement of LFP multi-band power spectral density (p 0.001). Finally, the excitatory rebound caused by excitatory-inhibiting imbalance in the neural circuit is verified by establishing a computational simulation model. As an intrinsic feature of the neural network , it may be a neural mechanism that leads to poor monotherapy treatment of sodium valproate. Therefore, this neuroexciting rebound can be used as one of the predictors of postoperative epilepsy control effect.
Associate Researcher Wang Deheng, School of Basic Medicine, our school is the corresponding author of , Professor Chen Liang and Professor Mao Ying, Affiliated to Fudan University, are the co-corresponding authors, Dr. Zou Xiang, Huashan Hospital, 2018 master's student in the Basic Medicine, Zhu Zilu, Dr. Guo Yu of Huashan Hospital, and Associate Professor Zhang Hongmiao of Suzhou University are the co-first authors of the thesis, and our school is the first completed unit of the thesis. The research was supported by the National Natural Science Foundation of China's major instrument development project, the project , the Shanghai Science and Technology Commission's major project, and the Shanghai Health Identification and Evaluation Key Laboratory.
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