Diseases come from the mouth, and diseases also come from the mouth. The so-called "diseases come from the mouth", referring to the intestine as an important immune organ, and the intestinal flora enters the body through the mouth and plays an important immune regulation role in

2025/04/0121:30:36 regimen 1355

disease enters from the mouth, and the disease also comes out from the mouth

The so-called "disease enters from the mouth" refers to the intestine as an important immune organ , and intestinal bacterial flora enters the body through the mouth and plays an important immune regulation role in the intestine. The so-called "disease comes from the mouth" means that autoimmune disease can often affect the digestive tract, manifested as gastrointestinal symptoms such as oral ulcers, nausea, abdominal pain, and bloating. Intestinal immunity is dependent on each other, and clues of autoimmune disease can often be seen from the symptoms of the digestive tract. Today we will enter the body's largest microecological immune system - the digestive tract.

Immunologically "disease enters from the mouth"

Intestine is not only the digestive tract but also an important immune organ of the human body. 60-70% of the human body's immune cells and immunoglobulin A gather in the intestine, and the intestinal flora and the body's immune balance are closely related. Recent studies have shown that the occurrence of multiple autoimmune diseases such as systemic lupus erythematosus , ankylosing spondylitis, rheumatoid arthritis is related to the imbalance of the microenvironment of the intestinal flora, which once again confirms the principle of "disease entering from the mouth". In the future, intestinal flora transplantation is expected to treat a variety of autoimmune diseases.

6 Disease comes from the mouth—from the symptoms of the digestive tract, autoimmune disease

1, Oropharynx ( dry mouth , ulcers, chewing and dysphagia ):

oral ulcers (most common in lupus, berries and other immune diseases), dyscheming ( Sjogren syndrome and IgG4 digestive gland involves dry mouth with difficulty chewing chewing, rheumatoid arthritis and chewing pain also occurs after chewing pain, in addition, giant cell arteritis ischemia shows jaw lameness), throat involvement (dermatomyositis pharyngeal muscle group involves dysphagia , choking cough with water)

2, esophageal + stomach involvement ( acid reflux heartburn, sticky feeling after eating food; anorexia, nausea, premature fullness, abdominal pain):

esophageal adhesion or choking feeling, lupus often affects 1/3 of the upper esophageal peristalsis, and scleroderma often affects 2/3 of the lower esophageal dilation, which is often accompanied by repeated acid reflux and heartburn, and stomach discomfort (scleroderma-related premature fullness, anorexia, nausea, "watermelon stomach", gastric bleeding, etc.).

3, lower digestive tract (mostly symptoms of abdominal pain, abdominal distension, black stool, bloody stool, diarrhea and constipation alternating):

abdominal pain is found in lupus and vasculitis related peritonitis , mesenteric lipidoplasty; Organic lupus erythematosus 1 pseudo-intestinal obstruction , scleroderma intestinal flora ectopic recurrent diarrhea and alternate constipation; Betel disease intestinal ulcers, larger ulcers can lead to perforation and abdominal pain and peritonitis; 60% of colon or ileum inflammation in ankylosing spondylitis are usually asymptomatic, and abdominal discomfort and abnormal bowel movements may occur; lupus-related protein loss enteropathy (repeated severe hypoproteinemia, abdominal pain, diarrhea, and severe depression edema).

4, digestive gland (dry mouth, fat diarrhea, oil aversion, weight loss):

salivary gland involvement will cause dry mouth; liver and biliary tract system + pancreatic involvement anorexia greasy, skin and mucous membrane yellowing and other diseases, IgG4 autoimmune pancreatitis and IgG4-related sclerotic cholangitis, lupus-related hepatitis, MDA5-related liver steatosis, autoimmune hepatitis , etc. will affect the digestive gland and cause corresponding symptoms.

5, digestive system-related blood vessels: Buga syndrome (refractory ascites, liver and spleen atrophy, etc., can be seen in Bertellin disease and antiphospholipid antibody syndrome ), hemangioma and mesenteric vasculitis (repeated abdominal pain, black stool, etc., can be seen in polyarbitritis nodular , Bertellin disease and lupus related vasculitis).

6. Gastrointestinal function involvement: diarrhea, malabsorption and weight loss in Whipple disease; liver involvement of portal hypertension in sarcoidosis; fever and abdominal pain in autoinflammatory diseases such as familial Mediterranean fever ; intestinal vasculitis of MAGIC syndrome involves many and complicated digestive symptoms.

In short, the digestive tract is not only one of the largest immune organs in the body, but also an important organ that is easily involved in autoimmune diseases. Only by finding out the true culprits of rheumatism and immune diseases behind these symptoms in a timely manner can we achieve the goal of treating the symptoms and the root cause.

Source: Xi'an Jiaotong University Second Affiliated Hospital

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